Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/52510
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dc.contributor.authorHernández Vega, Julia Natividaden_US
dc.contributor.authorRodríguez Hernández, Ángelen_US
dc.contributor.authorStear, M. J.en_US
dc.contributor.authorConde-Felipe, M.en_US
dc.contributor.authorRodríguez, E.en_US
dc.contributor.authorPiedrafita, D.en_US
dc.contributor.authorGonzález, J. F.en_US
dc.date.accessioned2018-11-28T10:51:42Z-
dc.date.available2018-11-28T10:51:42Z-
dc.date.issued2016en_US
dc.identifier.issn0304-4017en_US
dc.identifier.urihttp://hdl.handle.net/10553/52510-
dc.description.abstractHaemonchus contortus (H. contortus) is a haematophagous parasite which causes important economic losses in small ruminants. On the island of Gran Canaria, two sheep breeds coexist which differ in their susceptibility to the infection with H. contortus; the resistant Canaria Hair Breed (CHB) sheep and the susceptible Canaria Sheep (CS) breed. The major target of resistance mechanisms in CHB sheep are directed to the adult parasite stage, reducing the worm burden, and decreased length and fecundity of surviving worms. Mucosal IgA (mIgA) has been shown to be an important regulator of immunity in Haemonchus and Teladorsagia infections; through correlations with larval stages where such mechanisms as antibody-dependent cell cytotoxicity and enzyme inhibition may mediate resistance. Here for the first time, we demonstrate a significant negative correlation between mIgA and adult worm length and fecundity only in the resistant CHB sheep. In contrast, and as reported in other sheep breeds, mIgA was only negatively correlated against the larval stage in the more susceptible CS breed. This study suggests mIgA may play a role in resistance to both larval and adult stages.en_US
dc.languageengen_US
dc.relation.ispartofVeterinary Parasitologyen_US
dc.sourceVeterinary Parasitology[ISSN 0304-4017],v. 223, p. 153-158en_US
dc.subject310907 Patologíaen_US
dc.subject240112 Parasitología animalen_US
dc.subject.otherCanaria hair breeden_US
dc.subject.otherCanaria sheepen_US
dc.subject.otherHaemonchus contortusen_US
dc.subject.otherImmunoglobulin-Aen_US
dc.subject.otherSheep-nematodaen_US
dc.subject.otherWorm-lengthen_US
dc.titlePotential role for mucosal IgA in modulating Haemonchus contortus adult worm infection in sheepen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.vetpar.2016.04.022en_US
dc.identifier.scopus84964492993-
dc.identifier.isi000377317200027-
dc.contributor.authorscopusid57188977277-
dc.contributor.authorscopusid57207006439-
dc.contributor.authorscopusid26643256100-
dc.contributor.authorscopusid7006119516-
dc.contributor.authorscopusid57188974191-
dc.contributor.authorscopusid6506630827-
dc.contributor.authorscopusid6602358369-
dc.contributor.authorscopusid7404492965-
dc.description.lastpage158en_US
dc.description.firstpage153en_US
dc.relation.volume223en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid5685596-
dc.contributor.daisngid13912365-
dc.contributor.daisngid171112-
dc.contributor.daisngid33646546-
dc.contributor.daisngid30819941-
dc.contributor.daisngid595971-
dc.contributor.daisngid1988579-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Hernandez, JN-
dc.contributor.wosstandardWOS:Hernandez, A-
dc.contributor.wosstandardWOS:Stear, MJ-
dc.contributor.wosstandardWOS:Conde-Felip, M-
dc.contributor.wosstandardWOS:Rodriguez, E-
dc.contributor.wosstandardWOS:Piedrafita, D-
dc.contributor.wosstandardWOS:Gonzalez, JF-
dc.date.coverdateJunio 2016en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr1,173
dc.description.jcr2,356
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR Parasitología, dermatologia y biopatologia veterinaria-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0002-3843-2509-
crisitem.author.orcid0000-0001-8282-2750-
crisitem.author.orcid0000-0002-9174-9708-
crisitem.author.orcid0000-0001-8692-990X-
crisitem.author.orcid0000-0001-7374-9256-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameHernández Vega, Julia Natividad-
crisitem.author.fullNameRodríguez Hernández,Ángel-
crisitem.author.fullNameStear, Michael-
crisitem.author.fullNameConde De Felipe,Magnolia María-
crisitem.author.fullNameRodríguez Ponce, Eligia-
crisitem.author.fullNamePiedrafita ,David-
crisitem.author.fullNameGonzález Pérez, Jorge Francisco-
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