Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/52273
Título: Is bone a target-tissue for the nervous system? New advances on the understanding of their interactions
Autores/as: Garcia Castellano, Jose Manuel 
Díaz-Herrera, P. 
Morcuende, J. A.
Clasificación UNESCO: 32 Ciencias médicas
240209 Osteología
Palabras clave: Nervous system
Bone
Fecha de publicación: 2000
Publicación seriada: The Iowa orthopaedic journal 
Resumen: Bone cells respond in specific ways to various hormones and growth factors, but the biology of skeletal innervation and its physiologic significance in bone metabolism is poorly understood. With the introduction of immunohistochemical staining techniques and new molecular biology tools, the knowledge in this field has significantly improved. In this review, we update current understanding of the effects of neuropeptides on bone metabolism, specifically vasoactive intestinal peptide (VIP) and calcitonin-gene related peptide (CGRP). In addition, new information concerning the role of growth factors, such as neurotrophins, is also discussed. There is strong evidence to suggest that bone can be a target of the nervous system. Further investigations in this field will allow us to answer questions related to pre-natal development, bone growth, fracture healing, osteoporosis, osteoarthritis or neoplasias of mesoderm origin.
URI: http://hdl.handle.net/10553/52273
ISSN: 1541-5457
Fuente: The Iowa orthopaedic journal[ISSN 1541-5457],v. 20, p. 49-58
Colección:Reseña
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