Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/51918
DC FieldValueLanguage
dc.contributor.authorReusken, Chantal B.E.M.
dc.contributor.authorHaagmans, Bart L.
dc.contributor.authorMüller, Marcel A.
dc.contributor.authorGutierrez, Carlos
dc.contributor.authorGodeke, Gert Jan
dc.contributor.authorMeyer, Benjamin
dc.contributor.authorMuth, Doreen
dc.contributor.authorRaj, V. Stalin
dc.contributor.authorVries, Laura Smits De
dc.contributor.authorCorman, Victor M.
dc.contributor.authorDrexler, Jan Felix
dc.contributor.authorSmits, Saskia L.
dc.contributor.authorEl Tahir, Yasmin E.
dc.contributor.authorDe Sousa, Rita
dc.contributor.authorvan Beek, Janko
dc.contributor.authorNowotny, Norbert
dc.contributor.authorvan Maanen, Kees
dc.contributor.authorHidalgo-Hermoso, Ezequiel
dc.contributor.authorBosch, Berend Jan
dc.contributor.authorRottier, Peter
dc.contributor.authorOsterhaus, Albert
dc.contributor.authorGortázar-Schmidt, Christian
dc.contributor.authorDrosten, Christian
dc.contributor.authorKoopmans, Marion P.G.
dc.contributor.otherGutierrez, Carlos
dc.contributor.otherMeyer, Bernhard
dc.contributor.otherSmits, Saskia
dc.contributor.otherVictor, Stalin Raj
dc.contributor.otherDrexler, Jan Felix
dc.contributor.otherCorman, Victor Max
dc.contributor.otherGortazar, Christian
dc.contributor.otherNowotny, Norbert
dc.contributor.otherOsterhaus, Albert
dc.contributor.otherHaagmans, Bart
dc.contributor.otherMueller, Marcel
dc.contributor.otherKoopmans, Marion
dc.date.accessioned2018-11-25T05:24:30Z-
dc.date.available2018-11-25T05:24:30Z-
dc.date.issued2013
dc.identifier.issn1473-3099
dc.identifier.urihttp://hdl.handle.net/10553/51918-
dc.description.abstractBackground A new betacoronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) has been identified in patients with severe acute respiratory infection. Although related viruses infect bats, molecular clock analyses have been unable to identify direct ancestors of MERS-CoV. Anecdotal exposure histories suggest that patients had been in contact with dromedary camels or goats. We investigated possible animal reservoirs of MERSCoV by assessing specific serum antibodies in livestock.Methods We took sera from animals in the Middle East (Oman) and from elsewhere (Spain, Netherlands, Chile). Cattle (n=80), sheep (n=40), goats (n=40), dromedary camels (n=155), and various other camelid species (n=34) were tested for specific serum IgG by protein microarray using the receptor-binding Si subunits of spike proteins of MERS-CoV, severe acute respiratory syndrome coronavirus, and human coronavirus 0C43. Results were confirmed by virus neutralisation tests for MERS-CoV and bovine coronavirus.Findings 50 of 50 (100%) sera from Omani camels and 15 of 105 (14%) from Spanish camels had protein-specific antibodies against MERS-CoV spike. Sera from European sheep, goats, cattle, and other camelids had no such antibodies. MERS-CoV neutralising antibody titres varied between 1/320 and 1/2560 for the Omani camel sera and between 1/20 and 1/320 for the Spanish camel sera. There was no evidence for cross-neutralisation by bovine coronavirus antibodies.Interpretation MERS-CoV or a related virus has infected camel populations. Both titres and seroprevalences in sera from different locations in Oman suggest widespread infection.
dc.publisher1473-3099
dc.relation.ispartofThe Lancet Infectious Diseases
dc.sourceLancet Infectious Diseases[ISSN 1473-3099],v. 13 (10), p. 859-866
dc.subject.otherBovine Coronavirus
dc.subject.otherBat Coronavirus
dc.subject.otherInfection
dc.subject.otherVirus
dc.subject.otherSequence
dc.subject.otherProtein
dc.subject.otherRisk
dc.subject.other2C
dc.titleMiddle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: A comparative serological study
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/S1473-3099(13)70164-6
dc.identifier.scopus84884377173
dc.identifier.isi000324899700020
dcterms.isPartOfLancet Infectious Diseases
dcterms.sourceLancet Infectious Diseases[ISSN 1473-3099],v. 13 (10), p. 859-866
dc.contributor.authorscopusid6602366009
dc.contributor.authorscopusid6701371301
dc.contributor.authorscopusid24068857400
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dc.contributor.authorscopusid55941508600
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dc.contributor.authorscopusid15753438200
dc.contributor.authorscopusid8571625100
dc.contributor.authorscopusid6506584763
dc.contributor.authorscopusid7004696675
dc.contributor.authorscopusid55657500600
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dc.contributor.authorscopusid6602635031
dc.contributor.authorscopusid55860128600
dc.contributor.authorscopusid7003681993
dc.contributor.authorscopusid7006145490
dc.contributor.authorscopusid55533604400
dc.contributor.authorscopusid7003830446
dc.contributor.authorscopusid7003813990
dc.contributor.authorscopusid7006736989
dc.description.lastpage866
dc.description.firstpage859
dc.relation.volume13
dc.type2Artículoes
dc.identifier.wosWOS:000324899700020
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dc.identifier.investigatorRIDE-2989-2012
dc.identifier.investigatorRIDQ-9413-2016
dc.identifier.investigatorRIDA-2953-2014
dc.identifier.investigatorRIDE-9670-2016
dc.identifier.investigatorRIDC-1004-2014
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dc.contributor.wosstandardWOS:Reusken, CBEM
dc.contributor.wosstandardWOS:Haagmans, BL
dc.contributor.wosstandardWOS:Muller, MA
dc.contributor.wosstandardWOS:Gutierrez, C
dc.contributor.wosstandardWOS:Godeke, GJ
dc.contributor.wosstandardWOS:Meyer, B
dc.contributor.wosstandardWOS:Muth, D
dc.contributor.wosstandardWOS:Raj, VS
dc.contributor.wosstandardWOS:Smits-De Vries, L
dc.contributor.wosstandardWOS:Corman, VM
dc.contributor.wosstandardWOS:Drexler, JF
dc.contributor.wosstandardWOS:Smits, SL
dc.contributor.wosstandardWOS:El Tahir, YE
dc.contributor.wosstandardWOS:De Sousa, R
dc.contributor.wosstandardWOS:van Beek, J
dc.contributor.wosstandardWOS:Nowotny, N
dc.contributor.wosstandardWOS:van Maanen, K
dc.contributor.wosstandardWOS:Hidalgo-Hermoso, E
dc.contributor.wosstandardWOS:Bosch, BJ
dc.contributor.wosstandardWOS:Rottier, P
dc.contributor.wosstandardWOS:Osterhaus, A
dc.contributor.wosstandardWOS:Gortazar, C
dc.contributor.wosstandardWOS:Drosten, C
dc.contributor.wosstandardWOS:Koopmans, MPG
dc.date.coverdateOctubre 2013
dc.identifier.ulpgces
dc.description.sjr9,584
dc.description.sjrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Medicina Veterinaria e Investigación Terapéutica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0003-0764-7408-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameGutiérrez Cabrera,Carlos Javier-
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