Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/51583
Title: Estrogen modulates norepinephrine-induced accumulation of adenosine cyclic monophosphate in a subpopulation of immortalized luteinizing hormone-releasing hormone secreting neurons from the mouse hypothalamus
Authors: Martínez-Morales, J. R.
Morales, A.
Marín, R.
Hernández-Jiménez, J. G.
Acevedo, A.
Guerra, B. 
Hernández, G.
López-Coviella, I.
Prieto, L.
Alonso, R.
UNESCO Clasification: 32 Ciencias médicas
Keywords: Estrogen
Norepinephrine
Cyclic adenosine monophosphate
GT1-7 cells
Luteinizing hormone-releasing hormone, et al
Issue Date: 2001
Journal: Neuroscience Letters 
Abstract: A subpopulation of luteinizing hormone-releasing hormone (LHRH)-producing cells that express the intermediate filament protein vimentin and the neuronal marker neurofilament 145, but not neurofilament 200 nor glial fibrillary acidic protein, has been isolated from GT1–7 cultures. These cells express the mRNA encoding estrogen receptor alpha (ERα) and respond to physiological concentrations of 17β-estradiol (E2) by reducing the accumulation of cyclic adenosine monophosphate induced by norepinephrine, but not that induced by direct activation of adenylate cyclase. These results indicate that the activity of LHRH-producing neurons may be directly modulated by estrogen. In addition, they are suggestive of an estrogen-dependent desensitization of the β-adrenoceptor in these cells.
URI: http://hdl.handle.net/10553/51583
ISSN: 0304-3940
DOI: 10.1016/S0304-3940(00)01722-5
Source: Neuroscience Letters[ISSN 0304-3940],v. 298, p. 61-64 (Enero 2001)
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