Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/51285
Title: Decreased production of AmpC-type β-lactamases associated with the development of resistance to quinolones in Citrobacter freundii strains
Authors: Tavío Pérez, María Del Mar 
Amicosante, G.
Franceschini, N.
Vila, J.
Ruiz, J.
Oratore, A.
Martín-Sánchez, A. M. 
Jiménez De Anta, M. T.
UNESCO Clasification: 32 Ciencias médicas
320103 Microbiología clínica
Keywords: Gram-Negative Bacteria
Escherichia-Coli
Polyacrylamide Gels
Kinetic-Parameters
Clinical Isolate, et al
Issue Date: 1999
Journal: Microbial Drug Resistance 
Abstract: The effect of fluoroquinolones in Citrobacter freundii strains that results in a decreased expression of cephalosporin-hydrolysing beta-lactamases was studied. Resistance to broad-spectrum cephalosporins and penicillins in two C, freundii clinical isolates was associated with moderate production of chromosomal AmpC-type-beta-lactamase in addition to changes in the outer membrane proteins profile with respect to wild-type C. freundii strains. Ten quinolone-resistant mutants were derived from the two clinical isolates using increasing fluoroquinolone concentrations. The level of susceptibility to cephalosporins and meropenem of these 10 mutants was increased and was associated with a 3.6-32% diminution in the hydrolyzing activity of their periplasmic extracts containing beta-lactamases on cephaloridine as compared with those from their parent strains, Susceptibility to cephalosporins and meropenem, as well as the expression of chromosomal AmpC-type-beta-lactamase in C, freundii strains, was influenced by the exposure to quinolones.
URI: http://hdl.handle.net/10553/51285
ISSN: 1076-6294
DOI: 10.1089/mdr.1999.5.235
Source: Microbial Drug Resistance[ISSN 1076-6294],v. 5, p. 235-240 (Enero 1999)
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

4
checked on Mar 24, 2024

WEB OF SCIENCETM
Citations

3
checked on Feb 25, 2024

Page view(s)

49
checked on Jan 23, 2024

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.