Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/51266
Título: Antimicrobial resistance among respiratory pathogens in Spain: Latest data and changes over 11 years (1996-1997 to 2006-2007)
Autores/as: Pérez-Trallero, Emilio
Martín-Herrero, Jose E.
Mazón, Ana
García-Delafuente, Celia
Robles, Purificación
Iriarte, Victor
Dal-Ré, Rafael
García-De-Lomas, Juan
Crespo, M. Dolores
Plazas, Joaquín
De Los Angeles Arroyo, M.
Andreu, Mariano
Gimeno, Adelina
Sanchez, Antonia
Blanco, Javier
Beteta, Alicia
Ausina, Vicente
Sauca, Goretti
Giménez, Montserrat
Barrón, Jorge
Martínez-Rienda, Inés
Marco, Francesc
Jiménez-De-Anta, María T.
Ojeda, Eva
Megías, Gregoria
Labayru, Cristina
De Los Angeles Mantecón, M.
Romero, Dolores
González-Rodríguez, José Carlos
Casal, Manuel
Ibarra, Ana
Gené, Amadeo
Sánchez, Margarita
Alós, J. Ignacio
De-La-Rosa, Manuel
Martínez-Brocal, Antonio
Calbo, Luis
Alados, Juan C.
De Francisco, Jose Luis
De Miguel, Constantino
López, Maria Dolores
Martín-Sánchez, Antonio M. 
Cañas, Fernando
Bouza, Emilio
Cercenado, Emilia
De Pablos, Manuela
Baquero, Fernando
Cantón, Rafael
Pinedo, Alfonso
Sánchez-Bernal, María A.
Segovia, Manuel
Yagüe, Genoveva
Fernández, Begoña
Fleites, Ana
Alvarez, Elena
García-Castro, Maria A.
Pérez, Jose L.
Torroba, Luis
Beristain, Xavier
Gil, Alberto
Larruskain, Julián
Bautista, Nínive
Gutiérrez, Isabel
Martinez, Luis
García-Riestra, Carlos
Cortizo, Sandra
Moldes, Luz
Gómez, Angeles
Perea, Evelio
Pascual, Alvaro
Santamaría, José María
Gómez, Frederic
Tapiol, Josefa
Nogueira, Jose M.
Gobernado, Miguel
López, Jose Luis
Esteban, Encarnación
Torres, Julio
Vasallo, Francisco J.
Rubio, Carmen
Oca, Mercedes
Clasificación UNESCO: 32 Ciencias médicas
320806 Quimioterapia
Palabras clave: Antimicrobial resistance
Respiratory pathogens
SAUCE project
Fecha de publicación: 2010
Publicación seriada: Antimicrobial Agents and Chemotherapy 
Resumen: A nationwide multicenter susceptibility surveillance study (Susceptibility to the Antimicrobials Used in the Community in España [SAUCE] project), SAUCE-4, including 2,559 Streptococcus pneumoniae, 2,287 Streptococcus pyogenes, and 2,736 Haemophilus influenzae isolates was carried out from May 2006 to June 2007 in 34 Spanish hospitals. Then, the results from SAUCE-4 were compared to those from all three previous SAUCE studies carried out in 1996-1997, 1998-1999, and 2001-2002 to assess the temporal trends in resistance and the phenotypes of resistance over the 11-year period. In SAUCE-4, on the basis of the CLSI breakpoints, penicillin (parenteral, nonmeningitis breakpoint) and cefotaxime were the antimicrobials that were the most active against S. pneumoniae (99.8% and 99.6%, respectively). Only 0.9% of isolates had a penicillin MIC of ≥2 μg/ml. In S. pyogenes, nonsusceptibility to erythromycin was observed in 19.4% of isolates. Among the H. influenzae isolates, a β-lactamase-positive prevalence of 15.7% was found. A statistically significant temporal decreasing trend over the 11-year period was observed for nonsusceptibility (from 60.0% to 22.9%) and resistance (from 36.5% to 0.9%) to penicillin and for the proportion of erythromycin-resistant isolates of S. pneumoniae of the macrolide-lincosamide-streptogramin B (MLSB) phenotype (from 98.4% to 81.3%). A similar trend was observed for the prevalence of ampicillin resistance (from 37.6% to 16.1%), β-lactamase production (from 25.7% to 15.7%), and β-lactamase-negative ampicillin resistance (BLNAR) in H. influenzae (from 13.5% to 0.7%). Among erythromycin-resistant isolates of S. pyogenes, a significant increasing trend in the prevalence of MLSB was observed (from 7.0% to 35.5%). SAUCE-4 confirms a generalized decline in the resistance of the main respiratory pathogens to the antimicrobials as well as a shift in their resistance phenotypes.
URI: http://hdl.handle.net/10553/51266
ISSN: 0066-4804
DOI: 10.1128/AAC.01548-09
Fuente: Antimicrobial Agents and Chemotherapy[ISSN 0066-4804],v. 54, p. 2953-2959 (Julio 2010)
Colección:Artículos
Vista completa

Citas SCOPUSTM   

93
actualizado el 24-mar-2024

Visitas

40
actualizado el 20-ene-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.