Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/51182
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dc.contributor.authorRuilope, Luis M.en_US
dc.contributor.authorFernández, R.en_US
dc.contributor.authorRodríguez-Pérez, J. C.en_US
dc.contributor.authorGarcía de Vinuesa, S.en_US
dc.contributor.authorGarrido, J.en_US
dc.contributor.authorRomero, R.en_US
dc.contributor.authorJarillo, D.en_US
dc.contributor.authorRaij, L.en_US
dc.contributor.authorAlvarez-Cantalapiedra, I.en_US
dc.contributor.authorLázaro de Mercado, Ma R.en_US
dc.contributor.authorGómez Campderá, F.en_US
dc.contributor.authorJarillo Ibáñez, D.en_US
dc.contributor.authorGarcía Martín, F.en_US
dc.contributor.authorMora-Maciá, J.en_US
dc.contributor.authorNieto, J.en_US
dc.contributor.authorVozmediano, C.en_US
dc.contributor.authorHortal, L.en_US
dc.contributor.authorPlaza, C.en_US
dc.contributor.authorAljama, P.en_US
dc.contributor.authorGómez-Carrasco, J. M.en_US
dc.contributor.authorSoriano, S.en_US
dc.contributor.authorPérez-García, A.en_US
dc.contributor.authorGarcés, L.en_US
dc.contributor.authorSegura, J.en_US
dc.contributor.authorBonet, J.en_US
dc.contributor.authorVigil-Medina, A.en_US
dc.contributor.authorGallar, P.en_US
dc.contributor.authorOliet, A.en_US
dc.contributor.authorBernis, C.en_US
dc.contributor.authorSánz-Guajardo, D.en_US
dc.contributor.otherRodriguez-Perez, J.C.-
dc.contributor.otherromero, ramon-
dc.contributor.otherSegura, Julian-
dc.date.accessioned2018-11-24T22:12:15Z-
dc.date.available2018-11-24T22:12:15Z-
dc.date.issued2002en_US
dc.identifier.issn0263-6352en_US
dc.identifier.urihttp://hdl.handle.net/10553/51182-
dc.description.abstractObjective: Guidelines recommend lower threshold and goal blood pressure (BP) for patients with proteinuria. BP reduction could be accompanied by a different fall in proteinuria depending of the antihypertensive drug. The objective was to compare proteinuria reduction when BP is lowered to the same level with different drugs. Design: Prospective, randomized, double-blind, controlled trial. Setting: 12 Spanish centres. Patients: A total of 119 patients with primary renal disease, blood pressure > 130/85 mmHg, proteinuria > 1 g/day, and creatinine clearance > or = 50 ml/min. Intervention: After a 4-week run-in placebo period, patients were randomized to: atenolol 50 mg/day; trandolapril 2 mg/day; verapamil 240 mg/day or verapamil 180 + trandolapril 2 mg/day combination; forced double-dose titration was carried out at the 4th week. Treatment duration was 6 months. Outcome measures: Changes in BP, 24 h proteinuria, serum albumin and calcium. Results: BP was significantly reduced with the four treatments [SBP/DBP (mmHg]: atenolol 12.2/9.9; trandolapril 12.9/9.3; verapamil 8.2/7.9 and verapamil + trandolapril 13.6/11.3) without differences between them. A significant fall in proteinuria was seen in the trandolapril, 40.2% [95% confidence interval (CI) 24.3-56.2%], and verapamil + trandolapril groups, 48.5% (95% CI, 31.7-64.3%) accompanied with increases in serum albumin (trandolapril: from 3.86 +/- 0.64 to 4.03 +/- 0.67 g/dl; verapamil + trandolapril: from 4.15 +/- 0.58 to 4.40 +/- 0.51 g/dl). Conclusions: In patients with proteinuric primary renal disease, adequate dose titration of antihypertensive drugs may provide a substantial BP reduction. Only angiotensin-converting enzyme inhibitor (trandolapril) treatment, alone or better combined with verapamil, reduces proteinuria and increases serum albumin.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Hypertensionen_US
dc.sourceJournal of Hypertension[ISSN 0263-6352],v. 20(4), p. 729-737 (Abril 2002)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3205 Medicina internaen_US
dc.subject.otherBlood pressureen_US
dc.subject.otherPrimary renal diseaseen_US
dc.subject.otherProteinuriaen_US
dc.subject.otherTrandolaprilen_US
dc.subject.otherVerapamilen_US
dc.titleDissociation between blood pressure reduction and fall in proteinuria in primary renal disease: A randomized double-blind trialen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1097/00004872-200204000-00032en_US
dc.identifier.scopus0036528790-
dc.identifier.isi000174960500032-
dcterms.isPartOfJournal Of Hypertension-
dcterms.sourceJournal Of Hypertension[ISSN 0263-6352],v. 20 (4), p. 729-737-
dc.contributor.authorscopusid36039926200-
dc.contributor.authorscopusid56352846000-
dc.contributor.authorscopusid7005446255-
dc.contributor.authorscopusid6701791264-
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dc.contributor.authorscopusid7103176669-
dc.contributor.authorscopusid55418883800-
dc.contributor.authorscopusid7004016035-
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dc.contributor.authorscopusid35595320600-
dc.description.lastpage737en_US
dc.description.firstpage729en_US
dc.relation.volume20en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000174960500032-
dc.identifier.investigatorRIDC-1247-2010-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages9en_US
dc.utils.revisionen_US
dc.date.coverdateAbril 2002en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr3,534-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0003-0023-1063-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez Pérez, José Carlos-
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