Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/51162
Campo DC Valoridioma
dc.contributor.authorRíos, Nisa Buseten_US
dc.contributor.authorRodriguez Esparragon, Franciscoen_US
dc.contributor.authorRodriguez Perez, Jose C.en_US
dc.contributor.otherRodriguez-Esparragon, Francisco-
dc.contributor.otherRodriguez-Perez, J.C.-
dc.date.accessioned2018-11-24T22:00:57Z-
dc.date.available2018-11-24T22:00:57Z-
dc.date.issued2012en_US
dc.identifier.issn0147-958Xen_US
dc.identifier.urihttp://hdl.handle.net/10553/51162-
dc.description.abstractPurpose: Telmisartan, an angiotensin II receptor blocker (ARB), also acts as an activator of peroxisome proliferator-activated receptor-gamma (PPAR-gamma; PPAR-gamma). Several studies have explored the PPAR-gamma-endothelial nitric oxide synthase (eNOS) pathway associated with improvement of endothelial function by telmisartan. The ability of telmisartan to induce gene expression and protein level of eNOS and PPAR gamma in adipocytes was investigated.Methods: Expression of aP2, PPAR gamma, eNOS and iNOS genes were measured using the quantitative real-time polymerase chain reaction. The changes, at the protein level, were explored by Western blot, which evaluated the native and phosphorylated eNOS forms, eNOS-Ser(1177) and eNOS-Thr(495).Results: Adipocytes, exposed to telmisartan, exhibited an increase in PPAR gamma gene expression but a decrease in protein level. Nonetheless, after the exposure to telmisartan, eNOS-Ser(1177) phosphorylation, associated with eNOS activity increment, reached its highest value while eNOS-Thr(495) phosphorylation, involved in the inhibition of eNOS activity, showed its lowest value.Conclusion: The results suggest that telmisartan preserves eNOS activity via a mechanism that is partially independent of the PPAR gamma-eNOS pathway in adipocytes.en_US
dc.languageengen_US
dc.relation.ispartofClinical and Investigative Medicineen_US
dc.sourceClinical And Investigative Medicine[ISSN 0147-958X],v. 35 (2), p. E55-E64en_US
dc.subject32 Ciencias médicasen_US
dc.subject3205 Medicina internaen_US
dc.subject.otherActivated-Receptor-Gammaen_US
dc.subject.otherNitric-Oxide Synthaseen_US
dc.subject.otherHuman Adipose-Tissueen_US
dc.subject.other3T3-L1 Adipocytesen_US
dc.subject.otherModulating Activityen_US
dc.subject.otherRenin-Angiotensinen_US
dc.subject.otherType-1 Receptoren_US
dc.subject.otherPhosphorylationen_US
dc.subject.otherSystemen_US
dc.subject.otherDifferentiationen_US
dc.titleTelmisartan-induced eNOS gene expression is partially independent of its PPAR-gamma agonist propertyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.scopus84863751817-
dc.identifier.isi000302966500003-
dcterms.isPartOfClinical And Investigative Medicine-
dcterms.sourceClinical And Investigative Medicine[ISSN 0147-958X],v. 35 (2), p. E55-E64-
dc.contributor.authorscopusid53464098000-
dc.contributor.authorscopusid6504727864-
dc.contributor.authorscopusid7005446255-
dc.description.lastpageE64en_US
dc.description.firstpageE55en_US
dc.relation.volume35en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000302966500003-
dc.contributor.daisngid3498770-
dc.contributor.daisngid1305938-
dc.contributor.daisngid245684-
dc.identifier.investigatorRIDD-2810-2013-
dc.identifier.investigatorRIDC-1247-2010-
dc.description.numberofpages10en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Rios, NB-
dc.contributor.wosstandardWOS:Esparragon, FR-
dc.contributor.wosstandardWOS:Perez, JCR-
dc.date.coverdateJulio 2012en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr0,408-
dc.description.jcr1,085-
dc.description.sjrqQ1-
dc.description.jcrqQ4-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUSA-ONEHEALTH 5: Reproducción Animal, Oncología y Anestesiología Comparadas-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0003-1663-3673-
crisitem.author.orcid0000-0003-0023-1063-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez Esparragón,Francisco Javier-
crisitem.author.fullNameRodríguez Pérez,José Carlos-
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