Synthesis of new oxazolidine, oxazolidin‐2‐one and perhydro‐1,4‐oxazine derivatives of arylethanolamine as potential beta3‐adrenoceptor agonists

Abstract

The synthesis of new cyclic compounds, arylethanolamine derivatives, with potential beta3‐adrenoceptor agonist selectivity, which are associated with thermogenesis and regulation of insulin release, are described. Oxazolidine, oxazolidin‐2‐one, and perhydro‐1,4‐oxazine derivatives were obtained. The preliminary evaluation of the pharmacological effects of some of the synthesized compounds showed an activation of lypolysis in rat adipocytes with potency and efficiency similar to that observed for other accredited beta3‐adrenergic agonists.