Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/51106
DC FieldValueLanguage
dc.contributor.authorZafra, R.en_US
dc.contributor.authorJaber, J. R.en_US
dc.contributor.authorPérez-Écija, R. A.en_US
dc.contributor.authorBarragán, A.en_US
dc.contributor.authorMartínez-Moreno, A.en_US
dc.contributor.authorPérez, J.en_US
dc.date.accessioned2018-11-24T21:29:38Z-
dc.date.available2018-11-24T21:29:38Z-
dc.date.issued2008en_US
dc.identifier.issn0165-2427en_US
dc.identifier.urihttp://hdl.handle.net/10553/51106-
dc.description.abstractThe expression of iNOS by macrophages in 33 dogs suffering from spontaneous leishmaniasis was analysed by immunohistochemistry in skin, liver and lymph nodes. A correlation study between the number of macrophages expressing NOS and the number of macrophages containing leishmania amastigotes was carried out. Formalin-fixed paraffin-embedded tissue sections from the skin (28 cases), popliteal lymph nodes (8 cases) and liver (3 cases) of dogs of different age, sex and breed suffering from leishmaniasis were included in the study. Dogs were referred as positive for Leishmania spp by serology and the diagnosis was confirmed by demonstration of leishmania amastigotes within macrophages by histopathology. Tissue samples of skin (3 cases), popliteal lymph nodes (5 cases) and liver (3 cases) from dogs seronegative for leishmaniasis with no histopathological changes were included in the study as controls. The immunohistochemical study revealed that macrophages containing a high number of leishmania did not express iNOS. Con-elation between the number of macrophages expressing iNOS and the number of macrophages containing leishmania amastigotes was assessed using the Spearman test. High expression of iNOS in macrophages was related with low number of leishmania amastigotes in macrophages in all cases (r = -0.47, p = 0.002). These results suggest that iNOS expression by macrophages plays an important role during the control of Leishmania infection in dogs.en_US
dc.languageengen_US
dc.relation.ispartofVeterinary Immunology and Immunopathologyen_US
dc.sourceVeterinary Immunology and Immunopathology[ISSN 0165-2427],v. 123, p. 353-359en_US
dc.subject3109 Ciencias veterinariasen_US
dc.subject.otherNitric-Oxide Synthaseen_US
dc.subject.otherCutaneous Leishmaniasisen_US
dc.subject.otherImmune-Responseen_US
dc.subject.otherDogsen_US
dc.subject.otherChagasien_US
dc.subject.otherCellsen_US
dc.titleHigh iNOS expression in macrophages in canine leishmaniasis is associated with low intracellular parasite burdenen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.vetimm.2008.02.022en_US
dc.identifier.scopus43449122153-
dc.identifier.isi000256747800019-
dc.contributor.authorscopusid23029634000-
dc.contributor.authorscopusid7004667021-
dc.contributor.authorscopusid56601461400-
dc.contributor.authorscopusid57198344098-
dc.contributor.authorscopusid15725365500-
dc.contributor.authorscopusid55597088351-
dc.contributor.authorscopusid55597088343-
dc.description.lastpage359en_US
dc.description.firstpage353en_US
dc.relation.volume123en_US
dc.investigacionCienciasen_US
dc.type2Artículoen_US
dc.contributor.daisngid770447-
dc.contributor.daisngid959492-
dc.contributor.daisngid1856962-
dc.contributor.daisngid32213683-
dc.contributor.daisngid984836-
dc.contributor.daisngid319037-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Zafra, R-
dc.contributor.wosstandardWOS:Jaber, JR-
dc.contributor.wosstandardWOS:Perez-Ecija, R-
dc.contributor.wosstandardWOS:Barragan, A-
dc.contributor.wosstandardWOS:Martinez-Moreno, A-
dc.contributor.wosstandardWOS:Perez, J-
dc.date.coverdateJunio 2008en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.jcr1,907-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR Anatomía Aplicada y Herpetopatología-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0001-6116-7275-
crisitem.author.parentorgDepartamento de Morfología-
crisitem.author.fullNameJáber Mohamad, José Raduán-
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