Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/51059
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Conde-Martel, A. | en_US |
dc.contributor.author | González-Reimers, E. | en_US |
dc.contributor.author | Santolaria-Fernández, F. | en_US |
dc.contributor.author | Castro-Alemán, V. | en_US |
dc.contributor.author | Galindo-Martín, L. | en_US |
dc.contributor.author | Rodríguez-Moreno, F. | en_US |
dc.contributor.author | Martínez-riera, A. | en_US |
dc.date.accessioned | 2018-11-24T21:02:58Z | - |
dc.date.available | 2018-11-24T21:02:58Z | - |
dc.date.issued | 1992 | en_US |
dc.identifier.issn | 0741-8329 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/51059 | - |
dc.description.abstract | The present study has been performed in order to establish the relative and combined roles of ethanol and malnutrition on liver Fe, Zn, Cu, and Mn alterations in alcoholic male adult Wistar rats, and also the relationships between these alterations and histomorphometrically determined hepatocyte and nuclear areas, perivenular fibrotic rim area, and total amount of fat present in the liver. Four groups of 8 animals each were fed: (1) a nutritionally adequate diet (C); (2) a 36% ethanol-containing (as percent of energy), isocaloric diet (A); (3) a 2% protein-containing, isocaloric diet (PD); and (4) a 36% ethanol, 2% protein-containing, isocaloric diet (A-PD), respectively, following the Lieber-DeCarli model. Ethanol-fed, protein-deficient animals showed the highest liver Fe, and the lowest Zn and Cu values, although differences in liver Zn, Mn, and Cu values were not significantly different between PD and A-PD groups. Statistically significant differences of these parameters were observed between the A and the A-PD groups, and between the A and PD groups, except for liver iron. Except for liver Mn, differences between C and A groups were statistically significant. These alterations correlated with liver fibrosis and steatosis, serum albumin, and weight loss, except for liver Mn, which was not correlated with fibrosis or steatosis. Thus, protein deficiency seems to enhance ethanol-induced liver Fe, Zn, and Cu alterations, whereas protein deficiency, but not ethanol, seems to play a major role on liver Mn alterations. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Alcohol | en_US |
dc.source | Alcohol[ISSN 0741-8329],v. 9(5), p. 341-348 (Septiembre-octubre 1992) | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject | 3205 Medicina interna | en_US |
dc.subject.other | Iron | en_US |
dc.subject.other | Zinc | en_US |
dc.subject.other | Copper | en_US |
dc.subject.other | Manganese | en_US |
dc.subject.other | Alcoholic liver disease | en_US |
dc.subject.other | Malnutrition | en_US |
dc.subject.other | Protein deficiency | en_US |
dc.subject.other | Fibrosis | en_US |
dc.subject.other | Steatosis | en_US |
dc.subject.other | Liver histomorphometry | en_US |
dc.title | Combined effects of ethanol and protein deficiency on hepatic iron, zinc, manganese, and copper contents | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/0741-8329(92)90030-E | en_US |
dc.identifier.scopus | 0026768329 | - |
dc.contributor.authorscopusid | 7004460826 | - |
dc.contributor.authorscopusid | 7004694989 | - |
dc.contributor.authorscopusid | 6701348569 | - |
dc.contributor.authorscopusid | 6505757550 | - |
dc.contributor.authorscopusid | 6602769410 | - |
dc.contributor.authorscopusid | 6603811887 | - |
dc.contributor.authorscopusid | 6701763337 | - |
dc.description.lastpage | 348 | en_US |
dc.identifier.issue | 5 | - |
dc.description.firstpage | 341 | en_US |
dc.relation.volume | 9 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.description.numberofpages | 8 | en_US |
dc.utils.revision | Sí | en_US |
dc.date.coverdate | Septiembre-octubre 1992 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.scie | SCIE | - |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.author.dept | GIR IUIBS: Patología y Tecnología médica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Médicas y Quirúrgicas | - |
crisitem.author.orcid | 0000-0002-2540-3880 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Conde Martel, Alicia | - |
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