Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/51059
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dc.contributor.authorConde-Martel, A.en_US
dc.contributor.authorGonzález-Reimers, E.en_US
dc.contributor.authorSantolaria-Fernández, F.en_US
dc.contributor.authorCastro-Alemán, V.en_US
dc.contributor.authorGalindo-Martín, L.en_US
dc.contributor.authorRodríguez-Moreno, F.en_US
dc.contributor.authorMartínez-riera, A.en_US
dc.date.accessioned2018-11-24T21:02:58Z-
dc.date.available2018-11-24T21:02:58Z-
dc.date.issued1992en_US
dc.identifier.issn0741-8329en_US
dc.identifier.urihttp://hdl.handle.net/10553/51059-
dc.description.abstractThe present study has been performed in order to establish the relative and combined roles of ethanol and malnutrition on liver Fe, Zn, Cu, and Mn alterations in alcoholic male adult Wistar rats, and also the relationships between these alterations and histomorphometrically determined hepatocyte and nuclear areas, perivenular fibrotic rim area, and total amount of fat present in the liver. Four groups of 8 animals each were fed: (1) a nutritionally adequate diet (C); (2) a 36% ethanol-containing (as percent of energy), isocaloric diet (A); (3) a 2% protein-containing, isocaloric diet (PD); and (4) a 36% ethanol, 2% protein-containing, isocaloric diet (A-PD), respectively, following the Lieber-DeCarli model. Ethanol-fed, protein-deficient animals showed the highest liver Fe, and the lowest Zn and Cu values, although differences in liver Zn, Mn, and Cu values were not significantly different between PD and A-PD groups. Statistically significant differences of these parameters were observed between the A and the A-PD groups, and between the A and PD groups, except for liver iron. Except for liver Mn, differences between C and A groups were statistically significant. These alterations correlated with liver fibrosis and steatosis, serum albumin, and weight loss, except for liver Mn, which was not correlated with fibrosis or steatosis. Thus, protein deficiency seems to enhance ethanol-induced liver Fe, Zn, and Cu alterations, whereas protein deficiency, but not ethanol, seems to play a major role on liver Mn alterations.en_US
dc.languageengen_US
dc.relation.ispartofAlcoholen_US
dc.sourceAlcohol[ISSN 0741-8329],v. 9(5), p. 341-348 (Septiembre-octubre 1992)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3205 Medicina internaen_US
dc.subject.otherIronen_US
dc.subject.otherZincen_US
dc.subject.otherCopperen_US
dc.subject.otherManganeseen_US
dc.subject.otherAlcoholic liver diseaseen_US
dc.subject.otherMalnutritionen_US
dc.subject.otherProtein deficiencyen_US
dc.subject.otherFibrosisen_US
dc.subject.otherSteatosisen_US
dc.subject.otherLiver histomorphometryen_US
dc.titleCombined effects of ethanol and protein deficiency on hepatic iron, zinc, manganese, and copper contentsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/0741-8329(92)90030-Een_US
dc.identifier.scopus0026768329-
dc.contributor.authorscopusid7004460826-
dc.contributor.authorscopusid7004694989-
dc.contributor.authorscopusid6701348569-
dc.contributor.authorscopusid6505757550-
dc.contributor.authorscopusid6602769410-
dc.contributor.authorscopusid6603811887-
dc.contributor.authorscopusid6701763337-
dc.description.lastpage348en_US
dc.identifier.issue5-
dc.description.firstpage341en_US
dc.relation.volume9en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages8en_US
dc.utils.revisionen_US
dc.date.coverdateSeptiembre-octubre 1992en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Patología y Tecnología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-2540-3880-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameConde Martel, Alicia-
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