Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50952
Title: The exercising heart at altitude
Authors: Calbet, Jose A. L. 
Robach, Paul
Lundby, Carsten
UNESCO Clasification: 241106 Fisiología del ejercicio
Keywords: Hypoxia
Contractility
Cardiac output
Nitric oxide
Cardioprotection Infarct, et al
Issue Date: 2009
Publisher: 1420-682X
Journal: Cellular and Molecular Life Sciences 
Abstract: Maximal cardiac output is reduced in severe acute hypoxia but also in chronic hypoxia by mechanisms that remain poorly understood. In theory, the reduction of maximal cardiac output could result from: (1) a regulatory response from the central nervous system, (2) reduction of maximal pumping capacity of the heart due to insufficient coronary oxygen delivery prior to the achievement of the normoxic maximal cardiac output, or (3) reduced central command. In this review, we focus on the effects that acute and chronic hypoxia have on the pumping capacity of the heart, particularly on myocardial contractility and the molecular responses elicited by acute and chronic hypoxia in the cardiac myocytes. Special emphasis is put on the cardioprotective effects of chronic hypoxia. (Part of a multi-author review.)
URI: http://hdl.handle.net/10553/50952
ISSN: 1420-682X
DOI: 10.1007/s00018-009-0148-6
Source: Cellular And Molecular Life Sciences[ISSN 1420-682X],v. 66 (22), p. 3601-3613
Appears in Collections:Reseña
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