Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50927
DC FieldValueLanguage
dc.contributor.authorGuadalupe-Grau, A.en_US
dc.contributor.authorLarsen, Steenen_US
dc.contributor.authorGuerra Hernández, Carlos Borjaen_US
dc.contributor.authorCalbet, J. A. L.en_US
dc.contributor.authorDela, Flemmingen_US
dc.contributor.authorHelge, Jorn W.en_US
dc.contributor.otherLarsen, Steen-
dc.contributor.otherGuadalupe-Grau, Amelia-
dc.contributor.otherGuerra, Borja-
dc.contributor.otherHelge, Jorn-
dc.contributor.otherCalbet, Jose A-
dc.contributor.otherLarsen, Steen-
dc.contributor.otherDela, Flemming-
dc.date.accessioned2018-11-24T19:59:06Z-
dc.date.available2018-11-24T19:59:06Z-
dc.date.issued2014en_US
dc.identifier.issn1748-1708en_US
dc.identifier.urihttp://hdl.handle.net/10553/50927-
dc.description.abstractAim:Age associated fat mass accumulation could be because of dysregula-tion of leptin signalling in skeletal muscle. Thus, we investigated total pro-tein expression and phosphorylation levels of the long isoform of theleptin receptor (OB-Rb), and leptin signalling through janus kinase 2(JAK2)/signal transducer and activator of transcription 3 (STAT3), insulinreceptor substrate 1 (IRS-1), AMP-activated protein kinase (AMPK) andacetyl-coenzyme A carboxylase (ACC), combined with the leptin signallinginhibitors suppressor of cytokine signalling 3 (SOCS3) and protein tyrosinephosphatase 1B (PTP1B) in human skeletal muscle of different age.Methods:Vastus lateralis muscle biopsies were obtained from 39 menmatched for BMI<30 kg m 2and separated into three groups: 13 young(Y, 24 4 years); 14 middle aged (MA, 44 5 years) and 12 aged(A, 58 8 years) subjects.Results:Whole body fat percentage and plasma leptin were higher(P<0.05), whereas lean mass, plasma free testosterone and total testoster-one were lower (P<0.05) in A compared to Y. Skeletal muscle OB-Rb(170 KDa) protein expression and pTyr1141-OB-R170 were comparablebetween groups, whereas pTyr985-OB-R170 was lower in A compared toY(P<0.05). pSTAT3 levels tended (P=0.09) to be lower (50%) in Acompared to Y. In A, muscle PTP1B was greater and IRS-1 lower than Yand MA respectively (P<0.05). PTyr612-IRS-1 tended to be lower in Athan in Y (P=0.09). Suppressor of cytokine signalling 3 (SOCS3) proteinexpression, pJAK2, pSer1101-IRS-1, pAMPKaand pACCbwere similarbetween groups.Conclusion:Age is associated with dysregulation of the leptin signallingand increased PTP1B protein expression in skeletal muscle.Keywordsage, leptin resistance, androgens, insulin receptor substrate 1,protein tyrosine phosphatase 1B, skeletal muscle.en_US
dc.languageengen_US
dc.relationInfluencia Del Ejercicio Fisico, la Fio2 y El Estres Oxidativo en la Señalización Por Ampk en El Músculo Esquelético Humano.en_US
dc.relation.ispartofActa Physiologicaen_US
dc.sourceActa Physiologica[ISSN 1748-1708],v. 211 (1), p. 214-228en_US
dc.subject241106 Fisiología del ejercicioen_US
dc.subject.otherTyrosine-Phosphatase 1Ben_US
dc.subject.otherInsulin-Resistanceen_US
dc.subject.otherAdipose-Tissueen_US
dc.subject.otherGlucose-Metabolismen_US
dc.subject.otherProtein Expressionen_US
dc.subject.otherFree Testosteroneen_US
dc.subject.otherReceptoren_US
dc.subject.otherExerciseen_US
dc.subject.otherKinaseen_US
dc.subject.otherStat3en_US
dc.titleInfluence of age on leptin induced skeletal muscle signallingen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/apha.12273en_US
dc.identifier.scopus84898883941-
dc.identifier.isi000334488200022-
dcterms.isPartOfActa Physiologica-
dcterms.sourceActa Physiologica[ISSN 1748-1708],v. 211 (1), p. 214-228-
dc.contributor.authorscopusid25627673000-
dc.contributor.authorscopusid56499920500-
dc.contributor.authorscopusid7006442271-
dc.contributor.authorscopusid7004323423-
dc.contributor.authorscopusid57204336282-
dc.contributor.authorscopusid20334409300-
dc.description.lastpage228en_US
dc.description.firstpage214en_US
dc.relation.volume211en_US
dc.investigacionCiencias Sociales y Jurídicasen_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000334488200022-
dc.contributor.daisngid861361-
dc.contributor.daisngid390395-
dc.contributor.daisngid909211-
dc.contributor.daisngid90295-
dc.contributor.daisngid72876-
dc.contributor.daisngid147585-
dc.description.notasGrants from the Novo Nordisk Foundation, The Nordea Foundation, The Danish Medical Research Council, The Foundation of 1870 and the King Christian X's foundation.en_US
dc.identifier.investigatorRIDL-2069-2013-
dc.identifier.investigatorRIDH-4961-2016-
dc.identifier.investigatorRIDG-9739-2015-
dc.identifier.investigatorRIDI-7096-2012-
dc.identifier.investigatorRIDH-6693-2015-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Guadalupe-Grau, A-
dc.contributor.wosstandardWOS:Larsen, S-
dc.contributor.wosstandardWOS:Guerra, B-
dc.contributor.wosstandardWOS:Calbet, JAL-
dc.contributor.wosstandardWOS:Dela, F-
dc.contributor.wosstandardWOS:Helge, JW-
dc.date.coverdateEnero 2014en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-FISen_US
dc.description.sjr1,793
dc.description.jcr4,382
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.project.principalinvestigatorDorado García, Cecilia-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Educación Física-
crisitem.author.orcid0000-0003-4355-5682-
crisitem.author.orcid0000-0002-9215-6234-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameGuerra Hernández, Carlos Borja-
crisitem.author.fullNameLópez Calbet, José Antonio-
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