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Title: Effects of starvation in rats on serum levels of testosterone, dihydrotestosterone and testicular 3β-hydroxysteroid dehydrogenase activity
Authors: Fanjul, L. F. 
Ruiz de Galarreta, C. M.
UNESCO Clasification: 32 Ciencias médicas
230215 Hormonas
230219 Procesos metabólicos
Keywords: Starvation
Male rat
Serum testosterone
Testicular 3β-hydroxysteroid dehydrogenase
Issue Date: 1981
Journal: Hormone and Metabolic Research 
Abstract: Adult male rats were maintained on the following dietary regimes: full-fed for 28 days (controls); full-fed 21 days followed by no feed for seven days (acutely starved); no feed for seven days followed by 1/4 feed for 14 days (chronically starved); no feed for seven days, 1/4 of the normal diet for 14 days, and complete return of feed for seven days (refed). Serum testosterone (T) and dihydrote testosterone (DHT) were measured by radioimmunoassay and testicular Δ5-3β-hydroxysteroid-dehydrogenase (3β-HSD) activity was measured by a pregnenolone depletion method. Prostate, seminal vesicles and seminal fluid weight, as well as number of epidydimal spermatozoa were reduced in all starved groups. Serum androgens and testicular Δ5-3β-HSD activity were significantly reduced in acutely and chronically starved rats. After seven days of refeeding, serum levels of T, DHT, as well as testicular 3β-HSD activity rose to control values. In addition, the accessory organ weights and number of epidydimal spermatozoa followed a similar pattern. These data provide further evidence that starvation results in impaired testicular function which is reversed by refeeding.
ISSN: 0018-5043
DOI: 10.1055/s-2007-1019265
Source: Hormone and Metabolic Research[ISSN 0018-5043],v. 13(6), p. 356-358
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