Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50756
DC FieldValueLanguage
dc.contributor.authorSosa, Manuelen_US
dc.contributor.authorJódar Gimeno, Estebanen_US
dc.contributor.authorArbelo, Elenaen_US
dc.contributor.authorDomínguez Cabrera, Casimiraen_US
dc.contributor.authorSaavedra Santana, Pedroen_US
dc.contributor.authorTorres, Armandoen_US
dc.contributor.authorSalido, Eduardoen_US
dc.contributor.authorLimiñana Cañal, Jose Mariaen_US
dc.contributor.authorGómez De Tejada Romero, Mª Jesúsen_US
dc.contributor.authorHernández Hernández, Diegoen_US
dc.date.accessioned2018-11-24T18:36:07Z-
dc.date.available2018-11-24T18:36:07Z-
dc.date.issued2004en_US
dc.identifier.issn0953-6205en_US
dc.identifier.urihttp://hdl.handle.net/10553/50756-
dc.description.abstractThe effects of chronic administration of estrogens on the lipid profile in males are not fully understood. We have studied the effect of chronic administration of estrogens on the lipid profile in a group of transsexual (TS) Canarian men who were taking estrogens and anti-androgens for a minimum of 3 years. In this cross-sectional study of cases (n=27) and controls (n=26), plasma lipid profile and selected biochemical and hormonal features were studied. TS subjects had shorter stature than controls, and, after adjusting for height and weight, we found that they had lower values of serum free testosterone (FT) and higher estradiol (E2) levels than controls. The TS group had lower total and low-density lipoprotein (LDL) cholesterol and lower apoprotein B (Apo B) levels than the control group. Biochemistry was similar in both groups. The distribution of estrogen receptor gene polymorphisms (ER-Pvu and ER-Xba) was also similar in both groups. Serum Apo B concentration was related to ER-Xba polymorphism. No other association between lipid profile and the distribution of ER-Pvu and ER-Xba was found. We conclude that the chronic administration of estrogens in men could produce an increase in serum estradiol, a decrease in free testosterone levels, and a reduction in total cholesterol, LDL-cholesterol, and Apo B levels. The ER-Xba polymorphism may influence the Apo B response to exogenous estrogen in males.en_US
dc.languageengen_US
dc.relation.ispartofEuropean Journal of Internal Medicineen_US
dc.sourceEuropean Journal of Internal Medicine[ISSN 0953-6205],v. 15, p. 231-237en_US
dc.subject32 Ciencias médicasen_US
dc.subject3205 Medicina internaen_US
dc.subject.otherEstrogenen_US
dc.subject.otherTranssexualsen_US
dc.subject.otherPolymorphismen_US
dc.titleSerum lipids and estrogen receptor gene polymorphisms in male-to-female transsexuals: Effects of estrogen treatmenten_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ejim.2004.04.009en_US
dc.identifier.scopus3543078149-
dc.contributor.authorscopusid7004134221-
dc.contributor.authorscopusid6603967088-
dc.contributor.authorscopusid16066822500-
dc.contributor.authorscopusid57213210672-
dc.contributor.authorscopusid7101986509-
dc.contributor.authorscopusid56677724200-
dc.contributor.authorscopusid56712278500-
dc.contributor.authorscopusid14023538500-
dc.contributor.authorscopusid6602356906-
dc.contributor.authorscopusid6507688533-
dc.contributor.authorscopusid7201790739-
dc.description.lastpage237en_US
dc.description.firstpage231en_US
dc.relation.volume15en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages7en_US
dc.utils.revisionen_US
dc.date.coverdateJulio 2004en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR SIANI: Ingeniería biomédica aplicada a estimulación neural y sensorial-
crisitem.author.deptIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.deptGIR Estadística-
crisitem.author.deptDepartamento de Matemáticas-
crisitem.author.orcid0000-0001-6845-2933-
crisitem.author.orcid0000-0003-1681-7165-
crisitem.author.parentorgIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.parentorgDepartamento de Matemáticas-
crisitem.author.fullNameSosa Henríquez,Manuel José-
crisitem.author.fullNameJódar Gimeno, Esteban-
crisitem.author.fullNameDomínguez Cabrera, Casimira-
crisitem.author.fullNameSaavedra Santana, Pedro-
crisitem.author.fullNameLimiñana Cañal, Jose Maria-
crisitem.author.fullNameGómez De Tejada Romero, Mª Jesús-
crisitem.author.fullNameHernández Hernández, Diego-
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