Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50744
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dc.contributor.authorNavarro, Mary C.en_US
dc.contributor.authorSosa, Manuelen_US
dc.contributor.authorDel Pino-Montes, Javieren_US
dc.contributor.authorTorres, Armandoen_US
dc.contributor.authorSalido, Eduardoen_US
dc.contributor.authorSaavedra Santana, Pedroen_US
dc.contributor.authorCorral-Gudino, Luisen_US
dc.contributor.authorMontilla, Carlos A.en_US
dc.date.accessioned2018-11-24T18:30:26Z-
dc.date.available2018-11-24T18:30:26Z-
dc.date.issued2007en_US
dc.identifier.issn1594-0667en_US
dc.identifier.urihttp://hdl.handle.net/10553/50744-
dc.description.abstractBackground and aims: An association between the polymorphism for transcription factor Sp1 in the gene COL1A1 and low bone density (BMD) and osteoporotic fractures has been described but not confirmed for all races and ages. The aim of this preliminary work was to ascertain whether this association is present in women from the Canary Islands. Methods: Polymerase chain reaction RFLP was used to determine COL1A1 polymorphism Sp1 in 199 consecutive outpatient post-menopausal Caucasian women from the Canary Islands, aged 50-70 years. BMD was measured at lumbar spine and hip by DXA and at third lumbar vertebrae by QCT. Prevalent vertebral fractures were recorded on standard lateral X-ray film. Non-vertebral osteoporotic fractures were registered by medical record and self-reported history. Biochemical markers (serum osteocalcin, tartrate-resistant acid phosphatase), blood calcium and phosphate were also assessed. Results: Distribution genotypes were 113 (50.8%) GG homozygotes, 73 (36.7%) Ss heterozygotes and 7 (3.5%) TT homozygotes. All patients with osteoporotic fractures carried the GG allele more frequently than TT homozygotic women. The odds ratio was 3.01 (95% CI 1.6-5.7) for prevalent vertebral fractures (n=62) and 2.33 (95% CI 1.2-4.4) for all osteoporotic fractures (n=65) for the T-carrying allele vs TT homozygotic women. There was no difference in BMD measured by DXA or QCT, nor in bone markers, blood calcium or phosphate. Conclusions: This preliminary study confirmed that the presence of at least one copy of the T allele is associated with osteoporotic fractures, but not with low BMD, in women from the Canary Islands.en_US
dc.languageengen_US
dc.relation.ispartofAging - Clinical and Experimental Researchen_US
dc.sourceAging Clinical and Experimental Research[ISSN 1594-0667],v. 19, p. 4-9 (Enero 2007)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3201 Ciencias clínicasen_US
dc.subject.otherVitamin-D-Receptoren_US
dc.subject.otherMineral Densityen_US
dc.subject.otherEstrogen-Receptoren_US
dc.subject.otherVertebral Fracturesen_US
dc.subject.otherTurnover Markersen_US
dc.subject.otherColia1 Geneen_US
dc.subject.otherAllelesen_US
dc.subject.otherRisken_US
dc.subject.otherMenen_US
dc.subject.otherPopulationen_US
dc.titleCollagen type 1 (COL1A1) Sp1 binding site polymorphisms is associated with osteoporotic fractures but not with bone density in post-menopausal women from the Canary Islands: A preliminary studyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/BF03325204en_US
dc.identifier.scopus34047222736-
dc.identifier.isi000245258100003-
dc.contributor.authorscopusid7201561727-
dc.contributor.authorscopusid7004134221-
dc.contributor.authorscopusid6603747505-
dc.contributor.authorscopusid56712278500-
dc.contributor.authorscopusid14023538500-
dc.contributor.authorscopusid56677724200-
dc.contributor.authorscopusid6506236514-
dc.contributor.authorscopusid12782882100-
dc.description.lastpage9en_US
dc.description.firstpage4en_US
dc.relation.volume19en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid2876430-
dc.contributor.daisngid34938799-
dc.contributor.daisngid891999-
dc.contributor.daisngid571850-
dc.contributor.daisngid61141-
dc.contributor.daisngid8838450-
dc.contributor.daisngid1766375-
dc.contributor.daisngid1048977-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Navarro, MC-
dc.contributor.wosstandardWOS:Sosa, M-
dc.contributor.wosstandardWOS:del Pino-Montes, J-
dc.contributor.wosstandardWOS:Torres, A-
dc.contributor.wosstandardWOS:Salido, E-
dc.contributor.wosstandardWOS:Saavedra, P-
dc.contributor.wosstandardWOS:Corral-Gudino, L-
dc.contributor.wosstandardWOS:Montilla, CA-
dc.date.coverdateEnero 2007en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr1,311-
dc.description.jcrqQ3-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR SIANI: Ingeniería biomédica aplicada a estimulación neural y sensorial-
crisitem.author.deptIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR Estadística-
crisitem.author.deptDepartamento de Matemáticas-
crisitem.author.orcid0000-0001-6845-2933-
crisitem.author.orcid0000-0003-1681-7165-
crisitem.author.parentorgIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.parentorgDepartamento de Matemáticas-
crisitem.author.fullNameSosa Henríquez, Manuel José-
crisitem.author.fullNameSaavedra Santana, Pedro-
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