Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/50726
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dc.contributor.authorSosa, Manuelen_US
dc.contributor.authorSaavedra Santana, Pedroen_US
dc.contributor.authorGómez De Tejada Romero, Mª Jesúsen_US
dc.contributor.authorMosquera, Joséen_US
dc.contributor.authorPérez-Cano, Ramónen_US
dc.contributor.authorOlmos, José Manuelen_US
dc.contributor.authorMuñoz-Torres, Manuelen_US
dc.contributor.authorAmérigo, María Joséen_US
dc.contributor.authorMoro, María Jesúsen_US
dc.contributor.authorDíaz-Curiel, Manuelen_US
dc.contributor.authorAlegre, Javieren_US
dc.contributor.authorMalouf, Jorgeen_US
dc.contributor.authorDel Pino, Javieren_US
dc.contributor.authorNogués, Xavieren_US
dc.contributor.authorTorrijos, Antonioen_US
dc.contributor.authorCastro, A.en_US
dc.contributor.authorMontoya Garcia, M. J.en_US
dc.contributor.authorVázquez Gámez, M. A.en_US
dc.contributor.authorValero, C.en_US
dc.contributor.authorGonzález Maclas, J.en_US
dc.contributor.authorAlonso, G.en_US
dc.contributor.authorMao, L.en_US
dc.contributor.authorNúñez, J. J.en_US
dc.contributor.authorPastor Palnas, A.en_US
dc.contributor.authorGarcia Arias, M.en_US
dc.contributor.authorFarrerons Minguella, J.en_US
dc.contributor.authorDiez Pérez, A.en_US
dc.contributor.authorQuintana, E.en_US
dc.contributor.authorHemández Hemández, D.en_US
dc.date.accessioned2018-11-24T18:21:48Z-
dc.date.available2018-11-24T18:21:48Z-
dc.date.issued2011en_US
dc.identifier.issn1594-0667en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/50726-
dc.description.abstractBackground and aims: An association between cardiovascular disease and osteoporosis is described. A number of drugs often used by patients with coronary heart disease, such as thiazides, statins and beta-blockers, have shown controversial effects on bone. 1) To study the possible association between coronary heart disease (CHD) and bone mass density (BMD), quantitative ultrasound measurements (QUS) and the prevalence of fragility and vertebral fractures. 2) To study the possible influence of a number of drugs, statins, thiazides and beta-blockers, on BMD and fractures. Methods: Case-control study performed on 74 postmenopausal women who had recently suffered from CHD, and 111 age-matched controls. BMD was measured by Dual X-Ray Absorptiometry (DXA) at the lumbar spine and proximal femur. Quantitative Ultrasound (QUS) was also measured at the heel. Vertebral fractures were diagnosed by lateral, thoracic and lumbar X-rays. The occurrence of non-vertebral fractures was determined by examination of medical records. Results: Patients with CHD had higher values of BMI. They had a higher prevalence of arterial hypertension and hyperlipidemia, and consequently higher consumption of beta-blockers and statins, but not of thiazides, and had lower alcohol consumption. Patients with CHD had higher BMD values, measured by DXA at the proximal femur, than controls, but there were no differences in DXA values at the lumbar spine or QUS at the heel between the two groups. The prevalence of all fragility factures was slightly higher in patients with CHD, but not to a significant extent. The prevalence of vertebral fractures was similar in the two groups. In a logistic analysis to identify factors associated with all fractures, beta-blockers were positively associated with fragility fractures, and DXA at the femoral neck was inversely associated with fragility fractures. Conclusions: Postmenopausal women with CHD have higher values of BMD at the proximal femur but, despite this, show a slight but nonsignificant increase in the prevalence of fragility fractures. Beta-blockers are independently associated with fragility fractures, but thiazides and statins are not.en_US
dc.languageengen_US
dc.relation.ispartofAging - Clinical and Experimental Researchen_US
dc.sourceAging - Clinical and Experimental Research [ISSN 1594-0667], v. 23 (2), p. 112-117, (Abril 2011)en_US
dc.subject320501 Cardiologíaen_US
dc.subject320108 Ginecologíaen_US
dc.subject.otherAtherosclerosisen_US
dc.subject.otherBeta-Blockersen_US
dc.subject.otherBone Mineral Densityen_US
dc.subject.otherCoronary Heart Diseaseen_US
dc.subject.otherFractureen_US
dc.subject.otherOsteoporosisen_US
dc.subject.otherQuantitative Ultrasounden_US
dc.titleBeta-blocker use is associated with fragility fractures in postmenopausal women with coronary heart diseaseen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.scopus79960923820-
dc.identifier.isi000292805800006-
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dc.identifier.eissn1720-8319-
dc.description.lastpage117en_US
dc.identifier.issue2-
dc.description.firstpage112en_US
dc.relation.volume23en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid574595-
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dc.description.numberofpages6en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Sosa, M-
dc.contributor.wosstandardWOS:Saavedra, P-
dc.contributor.wosstandardWOS:de Tejada, MJG-
dc.contributor.wosstandardWOS:Mosquera, J-
dc.contributor.wosstandardWOS:Perez-Cano, R-
dc.contributor.wosstandardWOS:Olmos, JM-
dc.contributor.wosstandardWOS:Munoz-Torres, M-
dc.contributor.wosstandardWOS:Amerigo, MJ-
dc.contributor.wosstandardWOS:Moro, MJ-
dc.contributor.wosstandardWOS:Diaz-Curiel, M-
dc.contributor.wosstandardWOS:Alegre, J-
dc.contributor.wosstandardWOS:Malouf, J-
dc.contributor.wosstandardWOS:del Pino, J-
dc.contributor.wosstandardWOS:Nogues, X-
dc.contributor.wosstandardWOS:Torrijos, A-
dc.date.coverdateAbril 2011en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr0,568
dc.description.jcr1,552
dc.description.sjrqQ2
dc.description.jcrqQ3
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR SIANI: Ingeniería biomédica aplicada a estimulación neural y sensorial-
crisitem.author.deptIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.deptGIR Estadística-
crisitem.author.deptDepartamento de Matemáticas-
crisitem.author.orcid0000-0001-6845-2933-
crisitem.author.orcid0000-0003-1681-7165-
crisitem.author.parentorgIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.parentorgDepartamento de Matemáticas-
crisitem.author.fullNameSosa Henríquez,Manuel José-
crisitem.author.fullNameSaavedra Santana, Pedro-
crisitem.author.fullNameGómez De Tejada Romero, Mª Jesús-
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