Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50711
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dc.contributor.authorMorales-Santana, Sonia
dc.contributor.authorDíez-Pérez, Adolfo
dc.contributor.authorOlmos, José M.
dc.contributor.authorNogués, Xavier
dc.contributor.authorSosa, Manuel
dc.contributor.authorDíaz-Curiel, Manuel
dc.contributor.authorPérez-Castrillón, José L.
dc.contributor.authorPérez-Cano, Ramón
dc.contributor.authorTorrijos, Antonio
dc.contributor.authorJodar, Esteban
dc.contributor.authorRio, Luis Del
dc.contributor.authorCaeiro-Rey, José R.
dc.contributor.authorReyes-García, Rebeca
dc.contributor.authorGarcía-Fontana, Beatriz
dc.contributor.authorGonzález-Macías, Jesús
dc.contributor.authorMuñoz-Torres, Manuel
dc.date.accessioned2018-11-24T18:14:35Z-
dc.date.available2018-11-24T18:14:35Z-
dc.date.issued2015
dc.identifier.issn0378-5122
dc.identifier.urihttp://hdl.handle.net/10553/50711-
dc.description.abstractIntroduction: The biological mechanisms associated with an inadequate response to treatment with bisphosphonates are not well known. This study investigates the association between circulating levels of sclerostin and estradiol with an inadequate clinical outcome to bisphosphonate therapy in women with postmenopausal osteoporosis.Methods: This case-control study is based on 120 Spanish women with postmenopausal osteoporosis being treated with oral bisphosphonates. Patients were classified as adequate responders (ARs, n = 66, mean age 68.2 +/- 8 years) without incident fractures during 5 years of treatment, or inadequate responders (IRs, n = 54, mean age 67 +/- 9 years), with incident fractures between Ti and 5 years of treatment. Bone mineral density (DXA), structural analysis of the proximal femur and structural/fractal analysis of the distal radius were assessed. Sclerostin concentrations were measured by ELISA and 17 beta-estradiol levels by radioimmunoassay based on ultrasensitive methods.Results: In the ARs group, sclerostin serum levels were significantly lower (p = 0.02) and estradiol concentrations significantly higher (p = 0.023) than in the IRs group. A logistic regression analysis was performed, including as independent variables in the original model femoral fracture load, 25 hydroxyvitamin D, previus history of fragility fracture, sclerostin and estradiol. Only previous history of fragility fracture (OR 14.04,95% CI 2.38-82.79, p = 0.004) and sclerostin levels (OR 1.11,95% Cl 1.02-1.20, p = 0.011), both adjusted by estradiol levels remained associated with IRs. Also, sclerostin concentrations were associated with the index of resistance to compression (IRC) in the fractal analysis of the distal radius, a parameter on bone microstructure.Conclusions: Sclerostin and estradiol levels are associated with the response to bisphosphonate therapy in women with postmenopausal osteoporosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
dc.publisher0378-5122
dc.relation.ispartofMaturitas
dc.sourceMaturitas[ISSN 0378-5122],v. 82, p. 402-410
dc.subject.otherVan-Buchem-Disease
dc.subject.otherSerum Sclerostin
dc.subject.otherBone-Formation
dc.subject.otherElderly-Women
dc.subject.otherHip Fracture
dc.subject.otherRisk-Factors
dc.subject.otherSost
dc.subject.otherPrediction
dc.subject.otherTurnover
dc.subject.otherHormones
dc.titleCirculating sclerostin and estradiol levels are associated with inadequate response to bisphosphonates in postmenopausal women with osteoporosis
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.maturitas.2015.08.007
dc.identifier.scopus84947869236
dc.identifier.isi000366076100013
dc.contributor.authorscopusid54885343500
dc.contributor.authorscopusid7003509345
dc.contributor.authorscopusid7006049629
dc.contributor.authorscopusid7004515486
dc.contributor.authorscopusid7004134221
dc.contributor.authorscopusid55951265800
dc.contributor.authorscopusid57194127730
dc.contributor.authorscopusid7006256736
dc.contributor.authorscopusid6603080165
dc.contributor.authorscopusid6603967088
dc.contributor.authorscopusid57189843103
dc.contributor.authorscopusid55909403100
dc.contributor.authorscopusid23989735900
dc.contributor.authorscopusid54885343800
dc.contributor.authorscopusid7005502565
dc.contributor.authorscopusid7006824938
dc.description.lastpage410
dc.description.firstpage402
dc.relation.volume82
dc.type2Artículoes
dc.contributor.daisngid2425194
dc.contributor.daisngid44210
dc.contributor.daisngid135671
dc.contributor.daisngid820637
dc.contributor.daisngid574595
dc.contributor.daisngid335181
dc.contributor.daisngid395064
dc.contributor.daisngid895461
dc.contributor.daisngid1787793
dc.contributor.daisngid385681
dc.contributor.daisngid1570060
dc.contributor.daisngid9581030
dc.contributor.daisngid609864
dc.contributor.daisngid2005178
dc.contributor.daisngid224702
dc.contributor.daisngid510444
dc.contributor.wosstandardWOS:Morales-Santana, S
dc.contributor.wosstandardWOS:Diez-Perez, A
dc.contributor.wosstandardWOS:Olmos, JM
dc.contributor.wosstandardWOS:Nogues, X
dc.contributor.wosstandardWOS:Sosa, M
dc.contributor.wosstandardWOS:Diaz-Curiel, M
dc.contributor.wosstandardWOS:Perez-Castrillon, JL
dc.contributor.wosstandardWOS:Perez-Cano, R
dc.contributor.wosstandardWOS:Torrijos, A
dc.contributor.wosstandardWOS:Jodar, E
dc.contributor.wosstandardWOS:Del Rio, L
dc.contributor.wosstandardWOS:Caeiro-Rey, JR
dc.contributor.wosstandardWOS:Reyes-Garcia, R
dc.contributor.wosstandardWOS:Garcia-Fontana, B
dc.contributor.wosstandardWOS:Gonzalez-Macias, J
dc.contributor.wosstandardWOS:Munoz-Torres, M
dc.date.coverdateDiciembre 2015
dc.identifier.ulpgces
dc.description.sjr1,165
dc.description.jcr3,12
dc.description.sjrqQ1
dc.description.jcrqQ1
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0001-6845-2933-
crisitem.author.fullNameSosa Henríquez, Manuel José-
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