Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/50711
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dc.contributor.authorMorales-Santana, Soniaen_US
dc.contributor.authorDíez-Pérez, Adolfoen_US
dc.contributor.authorOlmos, José M.en_US
dc.contributor.authorNogués, Xavieren_US
dc.contributor.authorSosa, Manuelen_US
dc.contributor.authorDíaz-Curiel, Manuelen_US
dc.contributor.authorPérez-Castrillón, José L.en_US
dc.contributor.authorPérez-Cano, Ramónen_US
dc.contributor.authorTorrijos, Antonioen_US
dc.contributor.authorJodar, Estebanen_US
dc.contributor.authorRio, Luis Delen_US
dc.contributor.authorCaeiro-Rey, José R.en_US
dc.contributor.authorReyes-García, Rebecaen_US
dc.contributor.authorGarcía-Fontana, Beatrizen_US
dc.contributor.authorGonzález-Macías, Jesúsen_US
dc.contributor.authorMuñoz-Torres, Manuelen_US
dc.date.accessioned2018-11-24T18:14:35Z-
dc.date.available2018-11-24T18:14:35Z-
dc.date.issued2015en_US
dc.identifier.issn0378-5122en_US
dc.identifier.urihttp://hdl.handle.net/10553/50711-
dc.description.abstractIntroduction: The biological mechanisms associated with an inadequate response to treatment with bisphosphonates are not well known. This study investigates the association between circulating levels of sclerostin and estradiol with an inadequate clinical outcome to bisphosphonate therapy in women with postmenopausal osteoporosis.Methods: This case-control study is based on 120 Spanish women with postmenopausal osteoporosis being treated with oral bisphosphonates. Patients were classified as adequate responders (ARs, n = 66, mean age 68.2 +/- 8 years) without incident fractures during 5 years of treatment, or inadequate responders (IRs, n = 54, mean age 67 +/- 9 years), with incident fractures between Ti and 5 years of treatment. Bone mineral density (DXA), structural analysis of the proximal femur and structural/fractal analysis of the distal radius were assessed. Sclerostin concentrations were measured by ELISA and 17 beta-estradiol levels by radioimmunoassay based on ultrasensitive methods.Results: In the ARs group, sclerostin serum levels were significantly lower (p = 0.02) and estradiol concentrations significantly higher (p = 0.023) than in the IRs group. A logistic regression analysis was performed, including as independent variables in the original model femoral fracture load, 25 hydroxyvitamin D, previus history of fragility fracture, sclerostin and estradiol. Only previous history of fragility fracture (OR 14.04,95% CI 2.38-82.79, p = 0.004) and sclerostin levels (OR 1.11,95% Cl 1.02-1.20, p = 0.011), both adjusted by estradiol levels remained associated with IRs. Also, sclerostin concentrations were associated with the index of resistance to compression (IRC) in the fractal analysis of the distal radius, a parameter on bone microstructure.Conclusions: Sclerostin and estradiol levels are associated with the response to bisphosphonate therapy in women with postmenopausal osteoporosis.en_US
dc.languageengen_US
dc.relation.ispartofMaturitasen_US
dc.sourceMaturitas[ISSN 0378-5122],v. 82, p. 402-410 (Dicembre 2015)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320108 Ginecologíaen_US
dc.subject320107 Geriatríaen_US
dc.subject.otherVan-Buchem-Diseaseen_US
dc.subject.otherSerum Sclerostinen_US
dc.subject.otherBone-Formationen_US
dc.subject.otherElderly-Womenen_US
dc.subject.otherHip Fractureen_US
dc.subject.otherRisk-Factorsen_US
dc.subject.otherSosten_US
dc.subject.otherPredictionen_US
dc.subject.otherTurnoveren_US
dc.subject.otherHormonesen_US
dc.titleCirculating sclerostin and estradiol levels are associated with inadequate response to bisphosphonates in postmenopausal women with osteoporosisen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.maturitas.2015.08.007en_US
dc.identifier.scopus84947869236-
dc.identifier.isi000366076100013-
dc.contributor.authorscopusid54885343500-
dc.contributor.authorscopusid7003509345-
dc.contributor.authorscopusid7006049629-
dc.contributor.authorscopusid7004515486-
dc.contributor.authorscopusid7004134221-
dc.contributor.authorscopusid55951265800-
dc.contributor.authorscopusid57194127730-
dc.contributor.authorscopusid7006256736-
dc.contributor.authorscopusid6603080165-
dc.contributor.authorscopusid6603967088-
dc.contributor.authorscopusid57189843103-
dc.contributor.authorscopusid55909403100-
dc.contributor.authorscopusid23989735900-
dc.contributor.authorscopusid54885343800-
dc.contributor.authorscopusid7005502565-
dc.contributor.authorscopusid7006824938-
dc.description.lastpage410en_US
dc.description.firstpage402en_US
dc.relation.volume82en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid2425194-
dc.contributor.daisngid44210-
dc.contributor.daisngid135671-
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dc.contributor.daisngid574595-
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dc.contributor.daisngid895461-
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dc.contributor.daisngid609864-
dc.contributor.daisngid2005178-
dc.contributor.daisngid224702-
dc.contributor.daisngid510444-
dc.description.numberofpages9en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Morales-Santana, S-
dc.contributor.wosstandardWOS:Diez-Perez, A-
dc.contributor.wosstandardWOS:Olmos, JM-
dc.contributor.wosstandardWOS:Nogues, X-
dc.contributor.wosstandardWOS:Sosa, M-
dc.contributor.wosstandardWOS:Diaz-Curiel, M-
dc.contributor.wosstandardWOS:Perez-Castrillon, JL-
dc.contributor.wosstandardWOS:Perez-Cano, R-
dc.contributor.wosstandardWOS:Torrijos, A-
dc.contributor.wosstandardWOS:Jodar, E-
dc.contributor.wosstandardWOS:Del Rio, L-
dc.contributor.wosstandardWOS:Caeiro-Rey, JR-
dc.contributor.wosstandardWOS:Reyes-Garcia, R-
dc.contributor.wosstandardWOS:Garcia-Fontana, B-
dc.contributor.wosstandardWOS:Gonzalez-Macias, J-
dc.contributor.wosstandardWOS:Munoz-Torres, M-
dc.date.coverdateDiciembre 2015en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,165-
dc.description.jcr3,12-
dc.description.sjrqQ1-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR SIANI: Ingeniería biomédica aplicada a estimulación neural y sensorial-
crisitem.author.deptIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.orcid0000-0001-6845-2933-
crisitem.author.parentorgIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.fullNameSosa Henríquez,Manuel José-
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