Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50611
DC FieldValueLanguage
dc.contributor.authorBoronat, Mauroen_US
dc.contributor.authorSaavedra, Pedroen_US
dc.contributor.authorPérez-Martín, Nuriaen_US
dc.contributor.authorLópez-Madrazo, María J.en_US
dc.contributor.authorRodríguez-Pérez, Carlosen_US
dc.contributor.authorNóvoa, Francisco J.en_US
dc.date.accessioned2018-11-24T17:25:37Z-
dc.date.available2018-11-24T17:25:37Z-
dc.date.issued2012en_US
dc.identifier.issn1475-2840en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/50611-
dc.description.abstractBackground: Recent data suggest that concentrations of lipoprotein(a) [Lp(a)] may be inversely associated with the risk of diabetes. This study analyzed the relationships between Lp(a) and both diabetes and insulin resistance in an adult cohort from the island of Gran Canaria, Spain. Methods: Lp(a), homeostasis model assessment for insulin resistance (HOMA-IR) and conventional risk factors for diabetes were assessed in a sample of 1,030 adult individuals participating in a cross-sectional population-based epidemiological survey in the city of Telde. Diabetes was defined according to the WHO 1999 criteria, or as a previous diagnosis of diabetes. To identify patients at risk for diabetes, an Lp(a) cutoff level of 46 mg/dl was selected previously using classification and regression tree analysis. A multivariate logistic regression model with L2-regularization was used to assess the independent effect of Lp(a) on diabetes and its interactions with variables traditionally linked to the disease. Additionally, to investigate the effect of Lp(a) on insulin resistance, a parametric model was developed to describe the relationship between age and HOMA-IR values in subjects with levels of Lp(a) ≤ 46 or >46 mg/dl. Results: Along with variables known to be associated with diabetes, including age, mean blood pressure, serum triglycerides, and an interaction term between age and low HDL cholesterol, the logistic model identified a significant inverse association for diabetes and the interaction term between age and Lp(a) levels >46 mg/dl. According to the proposed parametric model, HOMA-IR was significantly lower in subjects of all ages who had Lp(a) levels >46 mg/dl. Conclusions: These results suggest that the age-related increase in the probability of having diabetes is significantly lower in subjects with Lp(a) levels >46 mg/dl. This could be explained in part by a lower insulin resistance in this subset of the population.en_US
dc.languageengen_US
dc.relation.ispartofCardiovascular Diabetologyen_US
dc.sourceCardiovascular Diabetology [1475-2840],v. 11 (81)en_US
dc.subject320502 Endocrinologíaen_US
dc.subject.otherLp(A) Concentrationsen_US
dc.subject.otherSerum-Insulinen_US
dc.subject.otherRisken_US
dc.subject.otherGlucoseen_US
dc.subject.otherLipoprotein(A)en_US
dc.subject.otherDiabetesen_US
dc.subject.otherInsulin Resistanceen_US
dc.subject.otherHoma-Iren_US
dc.subject.otherAgeen_US
dc.titleHigh levels of lipoprotein(a) are associated with a lower prevalence of diabetes with advancing age: Results of a cross-sectional epidemiological survey in Gran Canaria, Spainen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1475-2840-11-81en_US
dc.identifier.scopus84863100136-
dc.identifier.isi000308711900001-
dc.contributor.authorscopusid7003952293-
dc.contributor.authorscopusid56677724200-
dc.contributor.authorscopusid25655277000-
dc.contributor.authorscopusid57206781411-
dc.contributor.authorscopusid26536142100-
dc.contributor.authorscopusid57203488493-
dc.contributor.authorscopusid12786120600-
dc.identifier.eissn1475-2840-
dc.identifier.issue81-
dc.relation.volume11en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid673494-
dc.contributor.daisngid8838450-
dc.contributor.daisngid8864174-
dc.contributor.daisngid8554851-
dc.contributor.daisngid13304721-
dc.contributor.daisngid556390-
dc.description.numberofpages6en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Boronat, M-
dc.contributor.wosstandardWOS:Saavedra, P-
dc.contributor.wosstandardWOS:Perez-Martin, N-
dc.contributor.wosstandardWOS:Lopez-Madrazo, MJ-
dc.contributor.wosstandardWOS:Rodriguez-Perez, C-
dc.contributor.wosstandardWOS:Novoa, FJ-
dc.date.coverdateJulio 2012en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,24
dc.description.jcr4,209
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR Diabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0001-8535-8543-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameBoronat Cortés, Mauro-
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