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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50572
DC FieldValueLanguage
dc.contributor.authorLéon, Franciscoen_US
dc.contributor.authorQuintana, Jen_US
dc.contributor.authorRivera, Augustoen_US
dc.contributor.authorEstevez, Fen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.otherQuintana, Jose-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherLeon, Francisco-
dc.date.accessioned2018-11-24T17:05:42Z-
dc.date.available2018-11-24T17:05:42Z-
dc.date.issued2004en_US
dc.identifier.issn0163-3864en_US
dc.identifier.urihttp://hdl.handle.net/10553/50572-
dc.description.abstractA new lanostanoid triterpene, 3-oxosulfurenic acid (1), together with three known triterpenes (3, 4, and 7) were isolated from the fruit bodies of Laetiporus sulphureus. Cytotoxicity of these compounds and their derivatives (2, 5, and 6) was evaluated on HL-60 cells. Further studies revealed that acetyl eburicoic acid (5) was the most potent apoptosis inducer. Apoptosis was accompanied by both the activation of caspase-3 and the fragmentation of poly(ADP-ribose) polymerase-1 and was also associated with an early release of cytochrome c from the mitochondria.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Natural Productsen_US
dc.sourceJournal Of Natural Products[ISSN 0163-3864],v. 67 (12), p. 2008-2011en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherFungien_US
dc.subject.otherAciden_US
dc.subject.otherIdentificationen_US
dc.subject.otherConstituentsen_US
dc.subject.otherActivationen_US
dc.subject.otherCaspasesen_US
dc.subject.otherSteroidsen_US
dc.subject.otherTrabeaen_US
dc.titleLanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cellsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/np049762oen_US
dc.identifier.scopus11844249348-
dc.identifier.isi000226070600009-
dcterms.isPartOfJournal Of Natural Products-
dcterms.sourceJournal Of Natural Products[ISSN 0163-3864],v. 67 (12), p. 2008-2011-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7102211501-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid7101636723-
dc.description.lastpage2011en_US
dc.description.firstpage2008en_US
dc.relation.volume67en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000226070600009-
dc.contributor.daisngid136703-
dc.contributor.daisngid128315-
dc.contributor.daisngid244051-
dc.contributor.daisngid384944-
dc.contributor.daisngid5695465-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages4en_US
dc.utils.revisionSíen_US
dc.contributor.wosstandardWOS:Leon, F-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Rivera, A-
dc.contributor.wosstandardWOS:Estevez, F-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.date.coverdateDiciembre 2004en_US
dc.identifier.ulpgcSíen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr2,202-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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