Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50551
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dc.contributor.authorMarrero, María Teresaen_US
dc.contributor.authorTejera, Saraen_US
dc.contributor.authorEstévez, Saraen_US
dc.contributor.authorQuintana, Joséen_US
dc.contributor.authorMayato, Carlosen_US
dc.contributor.authorDorta, Rosa L.en_US
dc.contributor.authorVázquez, Jesús T.en_US
dc.contributor.authorEstévez, Franciscoen_US
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherVazquez, Jesus-
dc.contributor.otherDorta, Rosa-
dc.contributor.otherQuintana, Jose-
dc.date.accessioned2018-11-24T16:55:48Z-
dc.date.available2018-11-24T16:55:48Z-
dc.date.issued2012en_US
dc.identifier.issn0960-894Xen_US
dc.identifier.urihttp://hdl.handle.net/10553/50551-
dc.description.abstractA series of alkyl α/β-(1→6)-diglucopyranosides 1-12 were synthesized and assessed for cytotoxicity against HL-60, U937, Molt-3 and MCF-7 cancer cell lines. The menthyl derivatives displayed strong cytotoxic properties showing IC50 values between 6 and 16 μM. Furthermore, we demonstrated that the selected synthetic (+)-menthyl β-(1→6)- diglucopyranoside 5 induces apoptotic cell death in human leukemia cells through a mechanism that involves activation of multiple caspases. Cell death was completely prevented by the non-specific caspase inhibitor z-VAD-fmk and found to be associated with the release of cytochrome c, an increase in the expression of Bax levels and a decrease in the generation of reactive oxygen species. © 2012 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisher0960-894X-
dc.relationEvaluación de Potenciales Compuestos Antileucémicos.en_US
dc.relation.ispartofBioorganic and Medicinal Chemistry Lettersen_US
dc.sourceBioorganic & Medicinal Chemistry Letters[ISSN 0960-894X],v. 22 (11), p. 3665-3670en_US
dc.subject2403 Bioquímicaen_US
dc.subject3209 Farmacologíaen_US
dc.subject.otherCrocinen_US
dc.subject.otherOligosaccharidesen_US
dc.subject.otherSaccharidesen_US
dc.subject.otherGlycosidesen_US
dc.subject.otherApoptosisen_US
dc.subject.otherInhibiten_US
dc.titleSynthetic menthyl α/β-(1→6)-diglucopyranosides-induced cell death in human leukemia cells is dependent on caspasesen_US
dc.title.alternativeSynthetic menthyl alpha/beta-(1 -> 6)-diglucopyranosides-induced cell death in human leukemia cells is dependent on caspasesen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bmcl.2012.04.035en_US
dc.identifier.scopus84861191515-
dc.identifier.isi000303980600016-
dcterms.isPartOfBioorganic & Medicinal Chemistry Letters-
dcterms.sourceBioorganic & Medicinal Chemistry Letters[ISSN 0960-894X],v. 22 (11), p. 3665-3670-
dc.contributor.authorscopusid55055343200-
dc.contributor.authorscopusid55195691200-
dc.contributor.authorscopusid53867837200-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid6505723386-
dc.contributor.authorscopusid7003598420-
dc.contributor.authorscopusid7401760933-
dc.contributor.authorscopusid7003810011-
dc.description.lastpage3670en_US
dc.identifier.issue11-
dc.description.firstpage3665en_US
dc.relation.volume22en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000303980600016-
dc.contributor.daisngid2743847-
dc.contributor.daisngid14135818-
dc.contributor.daisngid12083041-
dc.contributor.daisngid4613160-
dc.contributor.daisngid128315-
dc.contributor.daisngid3445083-
dc.contributor.daisngid1307439-
dc.contributor.daisngid597244-
dc.contributor.daisngid384944-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDK-6549-2014-
dc.identifier.investigatorRIDK-2914-2014-
dc.identifier.investigatorRIDK-5709-2014-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Marrero, MT-
dc.contributor.wosstandardWOS:Tejera, S-
dc.contributor.wosstandardWOS:Estevez, S-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Mayato, C-
dc.contributor.wosstandardWOS:Dorta, RL-
dc.contributor.wosstandardWOS:Vazquez, JT-
dc.contributor.wosstandardWOS:Estevez, F-
dc.date.coverdateJunio 2012en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,087
dc.description.jcr2,338
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptBioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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