Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50547
DC FieldValueLanguage
dc.contributor.authorBurmistrova, Olgaen_US
dc.contributor.authorSimões, M. Fátimaen_US
dc.contributor.authorRijo, Patríciaen_US
dc.contributor.authorQuintana, Joseen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.authorEstevez, Franciscoen_US
dc.contributor.otherEstevez, Francisco-
dc.contributor.otheriMed.ULisboa, iMed.ULisboa-
dc.contributor.otherSimoes, M. Fatima-
dc.contributor.otherSimoes, M Fatima-
dc.contributor.otherQuintana, Jose-
dc.contributor.otheriMed.ULisboa, NatProdChem-
dc.contributor.otherRijo, Patricia Dias de Mendonca-
dc.contributor.otherSimoes, M Fatima-
dc.date.accessioned2018-11-24T16:53:53Z-
dc.date.available2018-11-24T16:53:53Z-
dc.date.issued2013en_US
dc.identifier.issn0163-3864en_US
dc.identifier.urihttp://hdl.handle.net/10553/50547-
dc.description.abstractIn the present study, the cytotoxicity of 30 diterpenoids with an abietane or a halimane skeleton was determined against five human tumor cell lines (HL-60, U937, Molt-3, SK-MEL-1, and MCF-7). Diterpenoids containing an abietane skeleton including taxodone (1) and taxodione (2), as well as the semisynthetic derivatives 12, 14, 15, 17, and 22, were the most cytotoxic compounds for human leukemia cells. Overexpression of the protective mitochondrial proteins Bcl-2 and Bcl-x(L) did not confer resistance to abietane diterpene-induced cytotoxicity. Studies performed on HL-60 cells indicated that growth inhibition triggered by compounds 1, 12, 14, and 15 was caused by induction of apoptosis. This was prevented by the nonspecific caspase inhibitor Z-VAD-FMK and, in the case of compounds 14 and 15, reduced by the selective caspase-8 inhibitor Z-IETD-FMK. Cell death induced by these abietane diterpenes was found to be associated with the release of mitochondrial proteins, including cytochrome c, Smac/DIABLO, and AIF (apoptosis-inducing factor), accompanied by dissipation of the mitochondrial membrane potential (Delta Psi), and modulated by inhibition of extracellular signal-regulated kinases signaling and the p38 mitogen-activated protein kinase pathway.en_US
dc.languageengen_US
dc.relationEvaluación de Potenciales Compuestos Antileucémicos.en_US
dc.relation.ispartofJournal of Natural Productsen_US
dc.sourceJournal Of Natural Products[ISSN 0163-3864],v. 76 (8), p. 1413-1423en_US
dc.subject32 Ciencias médicasen_US
dc.subject320101 Oncologíaen_US
dc.subject.otherHuman Leukemia-Cellsen_US
dc.subject.otherPlectranthus-Ornatusen_US
dc.subject.otherSalvia-Miltiorrhizaen_US
dc.subject.otherCytotoxic Activityen_US
dc.subject.otherApoptosisen_US
dc.subject.otherDeathen_US
dc.subject.otherCaspasesen_US
dc.subject.otherPathwaysen_US
dc.subject.otherRooten_US
dc.titleAntiproliferative activity of abietane diterpenoids against human tumor cellsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/np400172ken_US
dc.identifier.scopus84883155925-
dc.identifier.isi000323630500004-
dcterms.isPartOfJournal Of Natural Products-
dcterms.sourceJournal Of Natural Products[ISSN 0163-3864],v. 76 (8), p. 1413-1423-
dc.contributor.authorscopusid54396785700-
dc.contributor.authorscopusid7102405767-
dc.contributor.authorscopusid8600601700-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7101636723-
dc.contributor.authorscopusid7003810011-
dc.description.lastpage1423en_US
dc.description.firstpage1413en_US
dc.relation.volume76en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000323630500004-
dc.contributor.daisngid4152189-
dc.contributor.daisngid1407382-
dc.contributor.daisngid631925-
dc.contributor.daisngid128315-
dc.contributor.daisngid5695465-
dc.contributor.daisngid384944-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDC-6292-2014-
dc.identifier.investigatorRIDK-1130-2012-
dc.identifier.investigatorRIDD-1469-2009-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDB-5387-2014-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages11en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Burmistrova, O-
dc.contributor.wosstandardWOS:Simoes, MF-
dc.contributor.wosstandardWOS:Rijo, P-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.contributor.wosstandardWOS:Estevez, F-
dc.date.coverdateAgosto 2013en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,516-
dc.description.jcr3,947-
dc.description.sjrqQ1-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.project.principalinvestigatorEstévez Rosas, Francisco Jesús-
crisitem.author.deptGIR Bioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptGIR Bioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
Appears in Collections:Artículos
Show simple item record

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.