Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50513
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dc.contributor.authorGutiérrez Cabrera, Carlos Javieren_US
dc.contributor.authorCorbera Sánchez, Juan Albertoen_US
dc.contributor.authorBayou, K.en_US
dc.contributor.authorVan Gool, F.en_US
dc.contributor.otherGutierrez, Carlos-
dc.contributor.otherCorbera, Juan Alberto-
dc.date.accessioned2018-11-24T16:37:29Z-
dc.date.available2018-11-24T16:37:29Z-
dc.date.issued2008en_US
dc.identifier.isbn9781573317146-
dc.identifier.issn0077-8923en_US
dc.identifier.urihttp://hdl.handle.net/10553/50513-
dc.description.abstractToxicity and therapeutic trials using Cymelarsan (an arsenical compound) against Trypanosoma evansi infection were carried out using chronically infected goats. For the toxicity trial, 40 goats were divided into four groups of 10 animals each; the first three groups received s.c. injections of 5, 10, and 15 mg/kg bw of Cymelarsan, respectively, and the last one served as control. No systemic reaction was observed in any goat throughout the experiment. For the therapeutic trial, 15 adult female goats were inoculated intravenously with at least 1 x 10(5) T evansi isolated in the Canary Islands. Six months after inoculation, the animals were treated with Cymelarsan at single dose of 0.3 mg/kg (5 animals), 0.5 mg/kg (5 animals), and 0.625 mg/kg (5 animals). At 4 and 6 weeks after treatment, two goats belonging to 0.3 mg/kg group showed recurrence of trypanosomes. Parasitemia, however, was negative in all animals belonging to 0.5 and 0.625 mg/kg groups until the end of the experiment (6 months after treatment). Thus, it can be concluded that Cymelarsan is a safe trypanocidal drug for goats and that the curative dose is 0.5 mg/kg or above.en_US
dc.languageengen_US
dc.relation.ispartofAnnals of the New York Academy of Sciencesen_US
dc.sourceAnnals of the New York Academy of Sciences [ISSN 0077-8923], v. 1149 (1), p. 331-333en_US
dc.subject310907 Patologíaen_US
dc.subject.otherBrucei-Bruceien_US
dc.subject.otherTb-Evansien_US
dc.subject.otherMel Cyen_US
dc.subject.otherEfficacyen_US
dc.titleUse of cymelarsan in goats chronically infected with Trypanosoma evansien_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.relation.conference9th Biennial Conference on Animal Biodiversity and Emerging Diseases - Prediction and Preventionen_US
dc.identifier.doi10.1196/annals.1428.095en_US
dc.identifier.scopus57849142584-
dc.identifier.isi000262400000082-
dcterms.isPartOfAnimal Biodiversity and Emerging Diseases: Prediction and Prevention-
dcterms.sourceAnimal Biodiversity and Emerging Diseases: Prediction and Prevention[ISSN 0077-8923],v. 1149, p. 331-333-
dc.contributor.authorscopusid7202545218-
dc.contributor.authorscopusid7003605164-
dc.contributor.authorscopusid6508265543-
dc.contributor.authorscopusid55299008400-
dc.contributor.authorscopusid6602429584-
dc.description.lastpage333en_US
dc.description.firstpage331en_US
dc.relation.volume1149en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000262400000082-
dc.contributor.daisngid475608-
dc.contributor.daisngid998883-
dc.contributor.daisngid9691436-
dc.contributor.daisngid9786584-
dc.contributor.daisngid30615076-
dc.identifier.investigatorRIDE-2989-2012-
dc.identifier.investigatorRIDK-2289-2014-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Gutierrez, C-
dc.contributor.wosstandardWOS:Corbera, JA-
dc.contributor.wosstandardWOS:Bayou, K-
dc.contributor.wosstandardWOS:van Gool, F-
dc.date.coverdateEnero 2008en_US
dc.identifier.conferenceidevents120650-
dc.identifier.ulpgces
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptTrypanosomosis, Resistencia a Antibióticos y Medicina Animal-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0003-0764-7408-
crisitem.author.orcid0000-0001-7812-2065-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameGutiérrez Cabrera, Carlos Javier-
crisitem.author.fullNameCorbera Sánchez, Juan Alberto-
crisitem.event.eventsstartdate17-06-2007-
crisitem.event.eventsenddate22-06-2007-
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