Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50480
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dc.contributor.authorGómez-Benítez, J.en_US
dc.contributor.authorDíaz Chico, Bonifacioen_US
dc.date.accessioned2018-11-24T16:22:02Z-
dc.date.available2018-11-24T16:22:02Z-
dc.date.issued1985en_US
dc.identifier.issn0022-4731en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/50480-
dc.description.abstractThe present paper describes the effect of three 17-β-estradiol (E2) doses (1, 10 and 500 ng E2/kg) on the cytosolic and nuclear estrogen receptor content of anterior pituitary (Ap) of ovariectomized rats. The estrogen receptors were measured by [3h]E2 exchange in cytosol and crude nuclear fractions. Two hours after the administration of 10 or 500 ng E2/kg the Rc showed a depletion to 20-30% of preinjection level. The 1 ng E2/kg dose did not provoke any Rc depletion. The Rc replenishment was completed 5 h after injection of 10 ng E2/kg, but it was delayed to 10 h after injection of 500 ng E2/kg. An increased amount of Rc over the control levels was produced by 1 and 10 ng E2/kg doses, but not by the 500 ng E2/kg. The Rn level in Ap increased significantly after all E2 doses, and their highest levels were similar for 1, 10 and 500 ng E2/kg. These results suggest that some estrogenic responses like synthesis of the estrogen receptor proteins, can be elicited without previous significant Rc depletion. The relationships between Rc and Rn in Ap suggest an autorregulatory mechanism for the control of the cellular level of unbound estrogen receptors, that can be altered by the exogenous E2.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Steroid Biochemistryen_US
dc.sourceJournal of Steroid Biochemistry [ISSN 0022-4731], v. 23 (1), p. 77-80 (Enero 1985)en_US
dc.subject310910 Cirugíaen_US
dc.subject.otherComparative Studyen_US
dc.subject.otherEstrogenen_US
dc.subject.otherRaten_US
dc.titleTime course of anterior pituitary estrogen receptor after low 17β-estradiol doses in ovariectomized ratsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/0022-4731(85)90263-8en_US
dc.identifier.scopus0021814735-
dc.identifier.isiA1985AMY6500011-
dc.contributor.authorscopusid6603202613-
dc.contributor.authorscopusid7003603506-
dc.description.lastpage80en_US
dc.identifier.issue1-
dc.description.firstpage77en_US
dc.relation.volume23en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid11506727-
dc.contributor.daisngid1724161-
dc.description.numberofpages4en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:GOMEZBENITEZ, J-
dc.contributor.wosstandardWOS:DIAZCHICO, BN-
dc.date.coverdateEnero 1985en_US
dc.identifier.ulpgces
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameDíaz Chico, Bonifacio-
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