Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50218
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dc.contributor.authorBarber, D.en_US
dc.contributor.authorArias, J.en_US
dc.contributor.authorBoquete, M.en_US
dc.contributor.authorCardona, V.en_US
dc.contributor.authorCarrillo, T.en_US
dc.contributor.authorGala, G.en_US
dc.contributor.authorGamboa, P.en_US
dc.contributor.authorC. García-Robaina, J.en_US
dc.contributor.authorHernández, D.en_US
dc.contributor.authorL. Sanz, M.en_US
dc.contributor.authorTabar, A. I.en_US
dc.contributor.authorVidal, C.en_US
dc.contributor.authorIpsen, H.en_US
dc.contributor.authorde la Torre, F.en_US
dc.contributor.authorLombardero, M.en_US
dc.date.accessioned2018-11-24T14:18:57Z-
dc.date.available2018-11-24T14:18:57Z-
dc.date.issued2012en_US
dc.identifier.issn0954-7894en_US
dc.identifier.urihttp://hdl.handle.net/10553/50218-
dc.description.abstractBackground There are few studies comparing the sensitization with mite allergens from different mite species which could potentially be the cause of allergy. Objective To improve the diagnosis of mite allergic patients from a diverse territory in which D. pteronyssinus/D. farinae mites together with storage mites could be present in the environment. Methods Four hundred and seventy-seven patients (both children and adults) from different regions, covering the main mite prevalent areas of Spain, were recruited. sIgE to eight allergens was measured together with SPT to whole mite extracts, level of mite allergen exposure, and specific IgG4. BAT and CAST was performed in a subgroup of patients. Results D. pteronyssinus and L. destructor were more prevalent in Atlantic areas, whereas D. farinae predominate in Mediterranean areas. About 90% of patients were sensitized to group 1 and/or group 2 allergens. Group 2 was the most prevalent, and the IgE response/intensity of sensitization in BAT was higher. sIgE to Der p 2/Der f 2 was almost fully cross-reactive, but no cross-reactivity was detected with Lep d 2. Group 1 allergens were also cross-reactive, but in some patients a species-specific response was observed. sIgE to Lep d 2 was associated with SPT results to storage mites. Sensitization to Der p 1 was more frequent in children, whereas Lep d 2 sensitization was more frequent in adults. A higher ratio IgE/IgG4 to Der p 2 was associated with the presence of allergic asthma. Conclusion An improved diagnosis algorithm has been established. Group 2 allergens seem to have a leading role in mite allergy, but as group 1 sensitization could be species-specific in some patients and its prevalence is higher in children, an adequate balance on major mite species and major allergens must be consider in the design of mite allergy vaccines.en_US
dc.languageengen_US
dc.relation.ispartofClinical and Experimental Allergyen_US
dc.sourceClinical and Experimental Allergy[ISSN 0954-7894],v. 42, p. 1129-1138 (Julio 2012)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320701 Alergiasen_US
dc.subject.otherComponent-resolved diagnosisen_US
dc.subject.otherDermatophagoidesen_US
dc.subject.otherMajor mitesen_US
dc.subject.otherMinor mitesen_US
dc.subject.otherMite allergyen_US
dc.subject.otherTropomyosinen_US
dc.titleAnalysis of mite allergic patients in a diverse territory by improved diagnostic toolsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/j.1365-2222.2012.03993.xen_US
dc.identifier.scopus84862558615-
dc.contributor.authorscopusid54407867900-
dc.contributor.authorscopusid57197185666-
dc.contributor.authorscopusid6603112106-
dc.contributor.authorscopusid18133374200-
dc.contributor.authorscopusid7003526269-
dc.contributor.authorscopusid57160855700-
dc.contributor.authorscopusid7003834917-
dc.contributor.authorscopusid55256209700-
dc.contributor.authorscopusid16156630700-
dc.contributor.authorscopusid55256209100-
dc.contributor.authorscopusid7004451212-
dc.contributor.authorscopusid55544210500-
dc.contributor.authorscopusid7004241770-
dc.contributor.authorscopusid36865763700-
dc.contributor.authorscopusid7006004846-
dc.description.lastpage1138en_US
dc.description.firstpage1129en_US
dc.relation.volume42en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages10en_US
dc.utils.revisionen_US
dc.date.coverdateJulio 2012en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,908-
dc.description.jcr4,789-
dc.description.sjrqQ1-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameCarrillo Díaz, Teresa-
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