Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/49734
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dc.contributor.authorDe Pablos-Velasco, Pedro
dc.date.accessioned2018-11-24T10:16:34Z-
dc.date.available2018-11-24T10:16:34Z-
dc.date.issued2010
dc.identifier.issn1477-9072
dc.identifier.urihttp://hdl.handle.net/10553/49734-
dc.description.abstractPioglitazone is an oral antidiabetic agent that decreases insulin resistance in adipose tissue, liver and muscles. This action is mediated by its link to a nuclear receptor called peroxisome proliferator-activated receptor-gamma. By improving insulin sensitivity, hepatic glucose production decreases and glucose uptake increases in the peripheral tissues. Beyond these effects on glucose metabolism, pioglitazone has positive effects on lipid metabolism, blood pressure, endothelial function, adiponectin and C-reactive protein levels. These make pioglitazone treatment effective beyond glucose control. In this article, current evidence concerning pioglitazone in the treatment of Type 2 diabetes will be reviewed.
dc.publisher1477-9072
dc.relation.ispartofExpert Review of Cardiovascular Therapy
dc.sourceExpert Review of Cardiovascular Therapy[ISSN 1477-9072],v. 8, p. 1057-1067
dc.subject.otherType-2 Diabetes-Mellitus
dc.subject.otherCongestive-Heart-Failure
dc.subject.otherAdverse Cardiovascular Events
dc.subject.otherIntima-Media Thickness
dc.subject.otherHigh-Risk Patients
dc.subject.otherGlycemic Control
dc.subject.otherClinical-Trial
dc.subject.otherDouble-Blind
dc.subject.otherEndothelial Function
dc.subject.otherMyocardial-Infarction
dc.titlePioglitazone: Beyond glucose control
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1586/ERC.10.98
dc.identifier.scopus77955187964
dc.identifier.isi000216573200010
dc.contributor.authorscopusid6603805479
dc.description.lastpage1067
dc.description.firstpage1057
dc.relation.volume8
dc.type2Artículoes
dc.contributor.daisngid739699
dc.contributor.wosstandardWOS:de Pablos-Velasco, P
dc.date.coverdate2010
dc.identifier.ulpgces
dc.description.esciESCI
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-9190-2581-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameDe Pablos Velasco, Pedro Luis-
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