Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/49720
Título: Hypoglycaemic episodes in patients with type 2 diabetes - risk factors andassociations with patient-reported outcomes: The PANORAMA Study
Autores/as: Simon, D.
de Pablos-Velasco, P. 
Parhofer, K. G.
Gönder-Frederick, L.
Lomon, I. Duprat
Vandenberghe, H.
Eschwège, E.
Bradley, C.
Clasificación UNESCO: 32 Ciencias médicas
320502 Endocrinología
Palabras clave: Quality-Of-Life
Glycemic Control
Epidemiologic Analysis
Impact
Metformin, et al.
Fecha de publicación: 2015
Publicación seriada: Diabetes and Metabolism 
Resumen: Aim. - To explore the frequency of hypoglycaemic episodes, their risk factors, and associations with patient-reported outcomes in patients with type 2 diabetes enrolled in the PANORAMA cross-sectional study.Methods. - Five thousand seven hundred and eighty-three patients aged >= 40 years with type 2 diabetes duration >= 1 year were recruited in nine European countries. Patients reported severe and non-severe hypoglycaemic episodes during the past year at a single study visit. Patient-reported outcomes were measured by the Audit of Diabetes-Dependent Quality of Life, Diabetes Treatment Satisfaction Questionnaires, Hypoglycaemia Fear Survey-II, and EQ-5D Visual Analog Scale.Results. - During the previous year, 4.4% of the patients experienced >= 1 severe hypoglycaemic episode; among those without severe hypoglycaemia, 15.7% experienced 2:1 non-severe episode. Patients experiencing any hypoglycaemic episode reported a greater negative impact of diabetes on quality of life, greater fear of hypoglycaemia, less treatment satisfaction and worse health status than those with no episodes. In multivariate analyses hypoglycaemia was significantly associated with longer diabetes duration; presence of microvascular and, to a lesser extent, macrovascular complications; treatment with insulin, glinides or sulfonylureas; and use of self-monitoring blood glucose.Conclusion. - In patients with type 2 diabetes, severe hypoglycaemic episodes were not uncommon and one in five experienced some form of hypoglycaemia during the previous year. Hypoglycaemia was associated with more negative patient-reported outcomes. The risk of hypoglycaemia increased with diabetes duration, presence of diabetes-related complications, use of self-monitoring blood glucose, insulin secretagogues, and insulin treatment.
URI: http://hdl.handle.net/10553/49720
ISSN: 1262-3636
DOI: 10.1016/j.diabet.2015.08.007
Fuente: Diabetes and Metabolism[ISSN 1262-3636],v. 41, p. 470-479
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