Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/49493
Title: | Rho GTPases in human cancer: An unresolved link to upstream and downstream transcriptional regulation | Authors: | Benitah, Salvador A. Valerón, Pilar F. Van Aelst, Linda Marshall, Christopher J. Lacal, Juan Carlos |
UNESCO Clasification: | 32 Ciencias médicas 320713 Oncología 2403 Bioquímica |
Keywords: | Rho GTPase Transcription factor Carcinogenesis |
Issue Date: | 2004 | Journal: | Biochimica et Biophysica Acta - Reviews on Cancer | Abstract: | The high incidence of overexpression of some members of the Rho family of GTPases in human tumors suggests that (1) these proteins are involved in cancer onset, and (2) they are potential candidates for a therapeutic intervention. In recent years, the characterization of downstream effectors to Rho GTPases has provided crucial clues on the general cellular effects that permit aberrant proliferation and adhesiveness of tumor cells. The activation of many of these effector proteins in turn results in the modulation of the activity of several transcription factors that play an important role at various levels of Rho signaling. The precise mechanisms by which Rho GTPases participate in carcinogenesis are still not fully understood. However, it is becoming more evident that the specific role of Rho overexpression in tumor initiation, progression and metastasis, as well as the nature and cause of such overexpression in specific human tumors (i.e., transient or stable; tumor environment-regulated; genetic or epigenetic) may be linked to the activation of specific signaling pathways that result in transcriptional regulation. In this review, we summarize the functions of Rho proteins in the regulation of several transcription factors and their relationship to tumor biology. | URI: | http://hdl.handle.net/10553/49493 | ISSN: | 0304-419X | DOI: | 10.1016/j.bbcan.2004.10.002 | Source: | Biochimica et Biophysica Acta - Reviews on Cancer [ISSN 0304-419X], v. 1705 (2), p. 121-132 (Diciembre 2004) |
Appears in Collections: | Artículos |
SCOPUSTM
Citations
124
checked on Sep 8, 2024
WEB OF SCIENCETM
Citations
119
checked on Sep 8, 2024
Page view(s)
28
checked on Mar 2, 2024
Google ScholarTM
Check
Altmetric
Share
Export metadata
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.