Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/49489
DC FieldValueLanguage
dc.contributor.authorZumbado, Manuel
dc.contributor.authorDomínguez-Díez, Agustín
dc.contributor.authorHernández, Juan Ramón
dc.contributor.authorDíaz, José María
dc.contributor.authorPalomar, Rosa
dc.contributor.authorGarcía-Plaza, Guillermo
dc.contributor.authorNavarro, Domingo
dc.contributor.authorBoada, LD
dc.contributor.otherDominguez-Boada, Luis
dc.contributor.otherZumbado, Manuel
dc.date.accessioned2018-11-24T07:58:48Z-
dc.date.available2018-11-24T07:58:48Z-
dc.date.issued2003
dc.identifier.issn0901-9928
dc.identifier.urihttp://hdl.handle.net/10553/49489-
dc.description.abstractThe protective effect of the 21-aminosteroid U-74389G was studied in an experimental model of partial ischaemia reperfusion liver injury. Previous studies have proven the remarkable potency of 21-aminosteroids to prevent oxidant-induced cell injury in vitro and in vivo. However, the capability of these compounds to limit oxidative injury in clinical trials has been considered to be less certain. The potential protective effect exerted by U-74389G on reduced and prolonged models of ischaemia reperfusion liver injury was studied in male rats subjected to 75 min. of segmentary hepatic ischaemia followed by 1 or 24 hr of reperfusion. Liver injury was evaluated by measuring serum levels of liver enzymes and by histopathological studies. The oxidative status of liver cells was measured by evaluating the levels of liver lipid peroxidation products such as malondialdehyde and the levels of reduced glutathione. Our results lead us to think that treatment with U-74389G (6 mg/kg) does not bring about any protective effect neither in the levels of transaminases nor in the percentage of hepatocellular necrosis and cellular infiltration observed in any reperfusion-period groups. In fact and in contrast with our expectations, U-74389G seemed to increase enzyme release. Furthermore, at the dose used, this 21-aminosteroid is not capable of inhibiting the lipoperoxidation processes, although it induced an important increase of GSH levels at any time-period of reperfusion. This last finding seem to suggest that U-74389G could increase the resistance to oxidant-induced liver tissue damage. However, our results show that, at the dose used, this compound did not exert any protective effect on liver tissue, thus explaining, at least partially, the absence of beneficial effects on the part of these compounds in clinical trials carried out to limit organ injury in transplants.
dc.publisher0901-9928
dc.relation.ispartofPharmacology and Toxicology
dc.sourcePharmacology & Toxicology[ISSN 0901-9928],v. 93 (5), p. 238-243
dc.subject.otherTirilazad Mesylate Protects
dc.subject.otherLipid-Peroxidation
dc.subject.otherAdenine-Nucleotide
dc.subject.otherLazaroid U-74389G
dc.subject.otherWarm Ischemia
dc.subject.otherFree-Radicals
dc.subject.otherBrain-Injury
dc.subject.otherCell Injury
dc.subject.otherGlutathione
dc.subject.otherMechanism
dc.titleEvaluation of the Potential Protective Effect of 21-Aminosteroid U-74389G on Liver Injury Induced by Reduced and Prolonged Partial Hepatic Ischaemia Reperfusion in Rats
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1046/j.1600-0773.2003.pto930507.x
dc.identifier.scopus0346874445
dc.identifier.isi000187107300006
dcterms.isPartOfPharmacology & Toxicology
dcterms.sourcePharmacology & Toxicology[ISSN 0901-9928],v. 93 (5), p. 238-243
dc.contributor.authorscopusid6603459604
dc.contributor.authorscopusid6506059695
dc.contributor.authorscopusid12798700700
dc.contributor.authorscopusid57212423061
dc.contributor.authorscopusid57198718700
dc.contributor.authorscopusid6602002012
dc.contributor.authorscopusid57205748789
dc.contributor.authorscopusid57079050200
dc.contributor.authorscopusid6505638569
dc.contributor.authorscopusid7004873659
dc.contributor.authorscopusid6603916807
dc.description.lastpage243
dc.description.firstpage238
dc.relation.volume93
dc.type2Artículoes
dc.identifier.wosWOS:000187107300006
dc.contributor.daisngid418822
dc.contributor.daisngid2622777
dc.contributor.daisngid17155874
dc.contributor.daisngid2262118
dc.contributor.daisngid3517878
dc.contributor.daisngid32252894
dc.contributor.daisngid13568739
dc.contributor.daisngid7357266
dc.contributor.daisngid1833931
dc.contributor.daisngid21650153
dc.contributor.daisngid697526
dc.identifier.investigatorRIDL-5577-2015
dc.identifier.investigatorRIDB-4495-2010
dc.contributor.wosstandardWOS:Zumbado, M
dc.contributor.wosstandardWOS:Dominguez-Diez, A
dc.contributor.wosstandardWOS:Hernandez, JR
dc.contributor.wosstandardWOS:Diaz, JM
dc.contributor.wosstandardWOS:Palomar, R
dc.contributor.wosstandardWOS:Garcia-Plaza, G
dc.contributor.wosstandardWOS:Navarro, D
dc.contributor.wosstandardWOS:Boada, LD
dc.date.coverdateNoviembre 2003
dc.identifier.ulpgces
dc.description.jcr1,302
dc.description.jcrqQ3
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGrupo de investigaciones infecciosas, nutricionales e inflamatorias en pacientes hospitalarios / Study Group on infectious, nutritional and inflammatory diseases in hospitalized patients-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-1534-7758-
crisitem.author.orcid0000-0002-0195-4565-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameZumbado Peña, Manuel Luis-
crisitem.author.fullNameHernández Hernández, Juan Ramón-
crisitem.author.fullNameDomínguez Boada, Luis María-
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