Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/49325
Campo DC | Valor | idioma |
---|---|---|
dc.contributor.author | Macías-Reyes, A. | en_US |
dc.contributor.author | Rodriguez-Esparragon, F. | en_US |
dc.contributor.author | Caballero-Hidalgo, A. | en_US |
dc.contributor.author | Hernández-Trujillo, Y. | en_US |
dc.contributor.author | Medina, A. | en_US |
dc.contributor.author | Rodriguez-Perez, J. C. | en_US |
dc.contributor.other | Rodriguez-Perez, J.C. | - |
dc.contributor.other | Rodriguez-Esparragon, Francisco | - |
dc.date.accessioned | 2018-11-24T06:16:30Z | - |
dc.date.available | 2018-11-24T06:16:30Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.issn | 1071-5762 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/49325 | - |
dc.description.abstract | The CYBA gene variants have been inconsistently associated with coronary heart disease (CHD) risk. A case-control study was conducted genotyping 619 subjects to explore the contribution of C242T and A640G to CHD risk in the population. A significant risk was found associated with GG homozygosity (odds ratio (OR) 2.132, 95% confidence interval, 1.113-4.085). The C242T variant was associated with CHD risk in women. Bias due to population stratification was analysed. Phenotype changes linked to these polymorphisms were evaluated. Superoxide measurements revealed higher production as indicated by the presence of the G and T alleles. Differences in mRNA concentration in heterozygous A640G samples were analysed. Higher levels of G allele mRNA compared with A allele mRNA were found. NAD(P)H oxidase p22phox sub-unit expression was evaluated with Western blot. Experiments revealed a gradual relationship in p22phox protein expression according to genotypes of the analysed variants. Those GG TT double homozygous showed increased p22phox protein expressions regarding AA CC double homozygous. This study has demonstrated increased expression and activity of the NAD(P)H system components during atherogenesis and the results could help explain the relevance of the A640G variant as a CHD marker. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Free Radical Research | en_US |
dc.source | Free Radical Research[ISSN 1071-5762],v. 42 (1), p. 82-92 | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject | 320704 Patología cardiovascular | en_US |
dc.subject.other | Nadph Oxidase P22Phox | en_US |
dc.subject.other | P22 Phox Gene | en_US |
dc.subject.other | Smooth-Muscle-Cells | en_US |
dc.subject.other | Nad(P)H Oxidase | en_US |
dc.subject.other | Artery-Disease | en_US |
dc.subject.other | Angiotensin-Ii | en_US |
dc.subject.other | Superoxide-Production | en_US |
dc.subject.other | Population-Structure | en_US |
dc.subject.other | Oxidative Stress | en_US |
dc.subject.other | Vascular Tissue | en_US |
dc.title | Insight into the role of CYBA A640G and C242T gene variants and coronary heart disease risk. A case-control study | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1080/10715760701796918 | en_US |
dc.identifier.scopus | 40649102487 | - |
dc.identifier.isi | 000252798100009 | - |
dcterms.isPartOf | Free Radical Research | - |
dcterms.source | Free Radical Research[ISSN 1071-5762],v. 42 (1), p. 82-92 | - |
dc.contributor.authorscopusid | 8311692000 | - |
dc.contributor.authorscopusid | 6603262370 | - |
dc.contributor.authorscopusid | 24829379200 | - |
dc.contributor.authorscopusid | 8758145300 | - |
dc.contributor.authorscopusid | 7202723590 | - |
dc.contributor.authorscopusid | 7005446255 | - |
dc.description.lastpage | 92 | en_US |
dc.description.firstpage | 82 | en_US |
dc.relation.volume | 42 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.wos | WOS:000252798100009 | - |
dc.contributor.daisngid | 5867264 | - |
dc.contributor.daisngid | 1305938 | - |
dc.contributor.daisngid | 2969359 | - |
dc.contributor.daisngid | 5660229 | - |
dc.contributor.daisngid | 74576 | - |
dc.contributor.daisngid | 245684 | - |
dc.identifier.investigatorRID | C-1247-2010 | - |
dc.identifier.investigatorRID | D-2810-2013 | - |
dc.description.numberofpages | 11 | en_US |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:Macias-Reyes, A | - |
dc.contributor.wosstandard | WOS:Rodriguez-Esparragon, F | - |
dc.contributor.wosstandard | WOS:Caballero-Hidalgo, A | - |
dc.contributor.wosstandard | WOS:Hernandez-Trujillo, Y | - |
dc.contributor.wosstandard | WOS:Medina, A | - |
dc.contributor.wosstandard | WOS:Rodriguez-Perez, JC | - |
dc.date.coverdate | Enero 2008 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.jcr | 2,826 | - |
dc.description.jcrq | Q2 | - |
dc.description.scie | SCIE | - |
item.fulltext | Sin texto completo | - |
item.grantfulltext | none | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH 5: Reproducción Animal, Oncología y Anestesiología Comparadas | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.dept | GIR IUIBS: Patología y Tecnología médica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.orcid | 0000-0003-1663-3673 | - |
crisitem.author.orcid | 0000-0003-0023-1063 | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Rodríguez Esparragón,Francisco Javier | - |
crisitem.author.fullName | Rodríguez Pérez,José Carlos | - |
Colección: | Artículos |
Citas SCOPUSTM
28
actualizado el 30-mar-2025
Citas de WEB OF SCIENCETM
Citations
27
actualizado el 30-mar-2025
Visitas
53
actualizado el 22-jun-2024
Google ScholarTM
Verifica
Altmetric
Comparte
Exporta metadatos
Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.