Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/48871
Campo DC Valoridioma
dc.contributor.authorGallardo Campos, Germánen_US
dc.contributor.authorLópez Blanco, Félixen_US
dc.contributor.authorRuiz De Galarreta, Carlos M.en_US
dc.contributor.authorFanjul Rodríguez, Luisa Fernandaen_US
dc.date.accessioned2018-11-24T01:43:08Z-
dc.date.available2018-11-24T01:43:08Z-
dc.date.issued2003en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10553/48871-
dc.description.abstractWe have examined the effects of tumor necrosis factor α (TNFα) and its second messenger, ceramide, on HMGCoA reductase, the rate-limiting enzyme in the mevalonate pathway. Treatment of human U-937 and HL-60 cells with TNFα or C2-ceramide inhibited both expression and activity of HMGCoA reductase in a time-dependent manner. Maturation of p21ras was also inhibited in a mevalonate-dependent fashion. The addition of mevalonate to both U-937 and HL-60 cells could also partially prevent TNFα and ceramide-induced apoptosis. These results support the hypothesis that the inhibition of HMGCoA reductase expression and the subsequent decrease in prenylation of proteins such as p21ras are part of the mechanism by which TNFα induces apoptosis in these cells.en_US
dc.languageengen_US
dc.relation.ispartofBiochemical and biophysical research communications (Print)en_US
dc.sourceBiochemical and Biophysical Research Communications, [ISSN 0006-291X], v. 300, p. 397-402 (Enero 2003)en_US
dc.subject32 Ciencias médicasen_US
dc.subject2302 Bioquímicaen_US
dc.subject.otherTumor necrosis factor αen_US
dc.subject.otherCeramideen_US
dc.subject.otherHMGCoA reductaseen_US
dc.subject.otherApoptosisen_US
dc.subject.otherIsoprenylationen_US
dc.subject.otherRas proteinsen_US
dc.titleHMGCoA reductase inhibition partially mediates tumor necrosis factor α-induced apoptosis in human U-937 and HL-60 cellsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/S0006-291X(02)02846-2en_US
dc.identifier.scopus0037427509-
dc.contributor.authorscopusid6603046608-
dc.contributor.authorscopusid6602478628-
dc.contributor.authorscopusid7003806034-
dc.contributor.authorscopusid7004158812-
dc.description.lastpage402en_US
dc.description.firstpage397en_US
dc.relation.volume300en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages6en_US
dc.utils.revisionen_US
dc.date.coverdateEnero 2003en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr2,836-
dc.description.jcrqQ2-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR Didáctica, Aprendizaje y Motivación en Contextos Específicos-
crisitem.author.deptDepartamento de Didácticas Específicas-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0002-1516-1750-
crisitem.author.orcid0000-0003-1167-9787-
crisitem.author.orcid0009-0000-1982-055X-
crisitem.author.parentorgDepartamento de Educación-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameGallardo Campos, Germán-
crisitem.author.fullNameLópez Blanco, Félix-
crisitem.author.fullNameFanjul Rodríguez, Luisa Fernanda-
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