Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48634
DC FieldValueLanguage
dc.contributor.authorRosado, S.en_US
dc.contributor.authorRua-Figueroa, I.en_US
dc.contributor.authorVargas, J. A.en_US
dc.contributor.authorGarcia-Laorden, M. I.en_US
dc.contributor.authorLosada-Fernandez, I.en_US
dc.contributor.authorMartin-Donaire, T.en_US
dc.contributor.authorPerez-Chacon, G.en_US
dc.contributor.authorRodriguez-Gallego, C.en_US
dc.contributor.authorNaranjo-Hernandez, A.en_US
dc.contributor.authorOjeda-Bruno, S.en_US
dc.contributor.authorCitores, M. J.en_US
dc.contributor.authorPerez-Aciego, P.en_US
dc.contributor.otherVargas, Juan Antonion-
dc.contributor.otherPerez-Chacon, Gema-
dc.contributor.otherNaranjo Hernandez, Antonio-
dc.contributor.otherGarcia-Laorden, M. Isabel-
dc.contributor.otherPerez-Chacon, Gema-
dc.contributor.otherRosado Garcia, Silvia-
dc.date.accessioned2018-11-23T23:35:44Z-
dc.date.available2018-11-23T23:35:44Z-
dc.date.issued2008en_US
dc.identifier.issn1744-3121en_US
dc.identifier.urihttp://hdl.handle.net/10553/48634-
dc.description.abstractThe purpose of this study was to examine whether several allelic variants in the polymorphic interleukin (IL)-10 promoter region were related with an increased risk of developing systemic lupus erythematosus (SLE) in Spanish patients from Canary Islands. Microsatellites (MS) at positions -4000 and -1200 (IL10R and IL10G, respectively) and single nucleotide polymorphisms (SNPs) (MS) at positions -1082G/A, -819C/T and -592C/A of the IL-10 promoter were analysed in patients with SLE and healthy controls from Canary Islands (Spain). We found that SNPs but not MS were associated with SLE. The GCC haplotype frequency was significantly higher in SLE patients (0.43) than in healthy donors (0.33) [P = 0.02; OR = 1.50 (95% CI = 1.06-2.14)], whereas the ACC haplotype was less represented in patients (0.28 vs. 0.37) [P = 0.02; OR = 0.64 (95% CI = 0.44-0.92)]. To assess the functional role of genotypes, serum IL-10 levels from patients and controls were quantified by ELISA. Also, the lipopolysaccharide-induced IL-10 secretion by monocytes from healthy controls was evaluated in vitro. Serum IL-10 levels were higher in patients [median (interquartile range) = 2.8 pg/mL (1.8-4.2)] than in controls [0.9 pg/mL (0-3.5)] (P = 0.02), but no association was observed between serum IL-10 levels or lipopolysaccharide-induced IL-10 secretion and the IL-10 promoter haplotypes. These data suggest that the IL-10 promoter haplotype that produces higher levels of cytokine is associated with SLE in patients from Canary Islands.en_US
dc.languageengen_US
dc.relation.ispartofInternational Journal of Immunogeneticsen_US
dc.sourceInternational Journal Of Immunogenetics[ISSN 1744-3121],v. 35 (3), p. 235-242en_US
dc.subject32 Ciencias médicasen_US
dc.subject3205 Medicina internaen_US
dc.subject.otherLupus erythematosusen_US
dc.subject.otherInterleukin-10en_US
dc.subject.otherHaplotypeen_US
dc.subject.otherGenotypeen_US
dc.titleInterleukin-10 promoter polymorphisms in patients with systemic lupus erythematosus from the Canary Islandsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/j.1744-313X.2008.00762.xen_US
dc.identifier.scopus43549103796-
dc.identifier.isi000255823400008-
dcterms.isPartOfInternational Journal Of Immunogenetics-
dcterms.sourceInternational Journal Of Immunogenetics[ISSN 1744-3121],v. 35 (3), p. 235-242-
dc.contributor.authorscopusid15123196600-
dc.contributor.authorscopusid6602687781-
dc.contributor.authorscopusid35554857000-
dc.contributor.authorscopusid6506073949-
dc.contributor.authorscopusid15122940300-
dc.contributor.authorscopusid8581215000-
dc.contributor.authorscopusid15122896100-
dc.contributor.authorscopusid6602114379-
dc.contributor.authorscopusid6603579089-
dc.contributor.authorscopusid6602428868-
dc.contributor.authorscopusid6603293575-
dc.contributor.authorscopusid6602739743-
dc.description.lastpage242en_US
dc.description.firstpage235en_US
dc.relation.volume35en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000255823400008-
dc.contributor.daisngid1088680-
dc.contributor.daisngid401261-
dc.contributor.daisngid319841-
dc.contributor.daisngid1683208-
dc.contributor.daisngid3847768-
dc.contributor.daisngid2418098-
dc.contributor.daisngid1778995-
dc.contributor.daisngid603384-
dc.contributor.daisngid550893-
dc.contributor.daisngid4801071-
dc.contributor.daisngid833956-
dc.contributor.daisngid3713831-
dc.identifier.investigatorRIDH-8933-2017-
dc.identifier.investigatorRIDG-1521-2018-
dc.identifier.investigatorRIDE-7910-2010-
dc.identifier.investigatorRIDB-3649-2019-
dc.identifier.investigatorRIDH-5954-2015-
dc.identifier.investigatorRIDH-7461-2017-
dc.description.numberofpages8en_US
dc.utils.revisionen_US
dc.date.coverdateJunio 2008en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr1,16-
dc.description.jcrqQ4-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Grupo de investigaciones infecciosas, nutricionales e inflamatorias en pacientes hospitalarios / Study Group on infectious, nutritional and inflammatory diseases in hospitalized patients-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-2013-6664-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez Gallego, José Carlos-
crisitem.author.fullNameNaranjo Hernández, Antonio-
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