Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/48630
Campo DC Valoridioma
dc.contributor.authorRua-Figueroa, I.en_US
dc.contributor.authorArencibia-Mireles, O.en_US
dc.contributor.authorElvira, M.en_US
dc.contributor.authorErausquin, C.en_US
dc.contributor.authorOjeda, S.en_US
dc.contributor.authorFrancisco, F.en_US
dc.contributor.authorNaranjo, A.en_US
dc.contributor.authorRodríguez-Gallego, C.en_US
dc.contributor.authorGarcia-Laorden, I.en_US
dc.contributor.authorRodríguez-Perez, J.en_US
dc.contributor.authorRodríguez-Lozano, C.en_US
dc.contributor.otherNaranjo Hernandez, Antonio-
dc.contributor.otherGarcia-Laorden, M. Isabel-
dc.contributor.otherRodriguez-Perez, J.C.-
dc.date.accessioned2018-11-23T23:33:19Z-
dc.date.available2018-11-23T23:33:19Z-
dc.date.issued2010en_US
dc.identifier.issn0003-4967en_US
dc.identifier.urihttp://hdl.handle.net/10553/48630-
dc.description.abstractObjectives To assess the changes in carotid intima-media thickness (IMT) and the associated risks factors in patients with low severity systemic lupus erythematosus (SLE). Methods Common carotid IMT measurements were obtained by ultrasound from 101 patients with SLE at an interval of 2 years. Cardiovascular risk factors, disease activity, accumulated damage, severity (Katz index) and biochemical parameters (including high sensitivity C-reactive protein, interleukin 6, C3a, C4a, C5a and homocysteine) were also assessed. Multiple linear regression was used to assess the effect of these variables on the end IMT measurement (eIMT) adjusted to the baseline measurement (bIMT). Results The cohort comprised 94.1% women, with a mean age at entry of 41.5 years and a mean disease duration of 12.1 years. An increase of 0.078 mm in IMT was detected over 2 years, from a mean bIMT of 0.37 mm to a mean eIMT of 0.44 mm (p<0.001). When adjusted for the bIMT, multiple linear regression identified bIMT, age at diagnosis, homocysteine, C3 and C5a as risk factors for IMT progression. Conclusions IMT significantly increases over 2 years in patients with SLE. Age, baseline IMT, C3, C5a anaphylatoxin and homocysteine are all associated risk factors, supporting a role for complement and homocysteine in the early stages of premature SLE-associated atherosclerosis.en_US
dc.languageengen_US
dc.relation.ispartofAnnals of the rheumatic diseasesen_US
dc.sourceAnnals of the Rheumatic Diseases[ISSN 0003-4967],v. 69, p. 1136-1139 (Junio 2010)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3205 Medicina internaen_US
dc.subject.otherAtherosclerosisen_US
dc.subject.otherSystemic lupus erythematosusen_US
dc.titleFactors involved in the progress of preclinical atherosclerosis associated with systemic lupus erythematosus: A 2-year longitudinal studyen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1136/ard.2008.104349en_US
dc.identifier.scopus77953691454-
dc.identifier.isi000278017700033-
dcterms.isPartOfAnnals Of The Rheumatic Diseases-
dcterms.sourceAnnals Of The Rheumatic Diseases[ISSN 0003-4967],v. 69 (6), p. 1136-1139-
dc.contributor.authorscopusid6602687781-
dc.contributor.authorscopusid57194837986-
dc.contributor.authorscopusid36196391500-
dc.contributor.authorscopusid6505890457-
dc.contributor.authorscopusid8654250900-
dc.contributor.authorscopusid6603342951-
dc.contributor.authorscopusid7003297397-
dc.contributor.authorscopusid6602114379-
dc.contributor.authorscopusid6506464908-
dc.contributor.authorscopusid7005446255-
dc.contributor.authorscopusid6603136298-
dc.description.lastpage1139en_US
dc.description.firstpage1136en_US
dc.relation.volume69en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000278017700033-
dc.contributor.daisngid401261-
dc.contributor.daisngid3721099-
dc.contributor.daisngid28431914-
dc.contributor.daisngid1224582-
dc.contributor.daisngid343824-
dc.contributor.daisngid1113798-
dc.contributor.daisngid550893-
dc.contributor.daisngid603384-
dc.contributor.daisngid6276504-
dc.contributor.daisngid245684-
dc.contributor.daisngid1048977-
dc.identifier.investigatorRIDE-7910-2010-
dc.identifier.investigatorRIDB-3649-2019-
dc.identifier.investigatorRIDC-1247-2010-
dc.description.numberofpages4en_US
dc.utils.revisionen_US
dc.date.coverdateJunio 2010en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr9,082-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Grupo de investigaciones infecciosas, nutricionales e inflamatorias en pacientes hospitalarios / Study Group on infectious, nutritional and inflammatory diseases in hospitalized patients-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-2013-6664-
crisitem.author.orcid0000-0002-4344-8644-
crisitem.author.orcid0000-0003-0023-1063-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameNaranjo Hernández, Antonio-
crisitem.author.fullNameRodríguez Gallego, José Carlos-
crisitem.author.fullNameRodríguez Pérez,José Carlos-
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