Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/48622
Campo DC Valoridioma
dc.contributor.authorOuederni, Moniaen_US
dc.contributor.authorSanal, Ozdenen_US
dc.contributor.authorIkincioǧullari, Aydanen_US
dc.contributor.authorTezcan, Ilhanen_US
dc.contributor.authorDogu, Figenen_US
dc.contributor.authorSologuren, Ithaisaen_US
dc.contributor.authorPedraza-Sánchez, Sigifredoen_US
dc.contributor.authorKeser, Melikeen_US
dc.contributor.authorTanir, Gonulen_US
dc.contributor.authorNieuwhof, Chrisen_US
dc.contributor.authorColino, Elenaen_US
dc.contributor.authorKumararatne, Dinakanthaen_US
dc.contributor.authorLevy, Jacoven_US
dc.contributor.authorKutukculer, Necilen_US
dc.contributor.authorAytekin, Caneren_US
dc.contributor.authorHerrera-Ramos, Estefaníaen_US
dc.contributor.authorBhatti, Micahen_US
dc.contributor.authorKaraca, Neslihanen_US
dc.contributor.authorBarbouche, Ridhaen_US
dc.contributor.authorBroides, Arnonen_US
dc.contributor.authorGoudouris, Ekaterinien_US
dc.contributor.authorFranco, José Luisen_US
dc.contributor.authorParvaneh, Nimaen_US
dc.contributor.authorReisli, Ismailen_US
dc.contributor.authorStrickler, Alexisen_US
dc.contributor.authorShcherbina, Annaen_US
dc.contributor.authorSomer, Ayperen_US
dc.contributor.authorSegal, Anthonyen_US
dc.contributor.authorAngel-Moreno, Alfonsoen_US
dc.contributor.authorLezana-Fernandez, José Luisen_US
dc.contributor.authorBejaoui, Mohameden_US
dc.contributor.authorBobadilla-Del Valle, Miriamen_US
dc.contributor.authorKachboura, Salemen_US
dc.contributor.authorSentongo, Timothyen_US
dc.contributor.authorBen-Mustapha, Imenen_US
dc.contributor.authorBustamante, Jacintaen_US
dc.contributor.authorPicard, Capucineen_US
dc.contributor.authorPuel, Anneen_US
dc.contributor.authorBoisson-Dupuis, Stéphanieen_US
dc.contributor.authorAbel, Laurenten_US
dc.contributor.authorCasanova, Jean Laurenten_US
dc.contributor.authorRodríguez-Gallego, Carlosen_US
dc.date.accessioned2018-11-23T23:28:40Z-
dc.date.available2018-11-23T23:28:40Z-
dc.date.issued2014en_US
dc.identifier.issn1058-4838en_US
dc.identifier.urihttp://hdl.handle.net/10553/48622-
dc.description.abstractBackground. Interleukin 12R beta 1 (IL-12R beta 1)-deficient patients are prone to clinical disease caused by mycobacteria, Salmonella, and other intramacrophagic pathogens, probably because of impaired interleukin 12-dependent interferon gamma production. About 25% of patients also display mucocutaneous candidiasis, probably owing to impaired interleukin 23-dependent interleukin 17 immunity. The clinical features and outcome of candidiasis in these patients have not been described before, to our knowledge. We report here the clinical signs of candidiasis in 35 patients with IL-12R beta 1 deficiency.Results. Most (n = 71) of the 76 episodes of candidiasis were mucocutaneous. Isolated oropharyngeal candidiasis (OPC) was the most common presentation (59 episodes, 34 patients) and was recurrent or persistent in 26 patients. Esophageal candidiasis (n = 7) was associated with proven OPC in 2 episodes, and cutaneous candidiasis (n = 2) with OPC in 1 patient, whereas isolated vulvovaginal candidiasis (VVC; n = 3) was not. Five episodes of proven invasive candidiasis were documented in 4 patients; 1 of these episodes was community acquired in the absence of any other comorbid condition. The first episode of candidiasis occurred earlier in life (median age +/- standard deviation, 1.5 +/- 7.87 years) than infections with environmental mycobacteria (4.29 +/- 11.9 years), Mycobacterium tuberculosis (4 +/- 3.12 years), or Salmonella species (4.58 +/- 4.17 years) or other rare infections (3 +/- 11.67 years). Candidiasis was the first documented infection in 19 of the 35 patients, despite the vaccination of 10 of these 19 patients with live bacille Calmette-Guerin.Conclusions. Patients who are deficient in IL-12R beta 1 may have candidiasis, usually mucocutaneous, which is frequently recurrent or persistent. Candidiasis may be the first clinical manifestation in these patients.en_US
dc.languageengen_US
dc.relation.ispartofClinical Infectious Diseasesen_US
dc.sourceClinical Infectious Diseases[ISSN 1058-4838],v. 58, p. 204-213en_US
dc.subject32 Ciencias médicasen_US
dc.subject320505 Enfermedades infecciosasen_US
dc.subject.otherChronic Mucocutaneous Candidiasisen_US
dc.subject.otherHyper-Ige Syndromeen_US
dc.subject.otherInborn-Errorsen_US
dc.subject.otherIl-12R-Beta-1 Deficiencyen_US
dc.subject.otherMycobacterial Diseaseen_US
dc.subject.otherStat1 Mutationsen_US
dc.subject.otherIl-17 Immunityen_US
dc.subject.otherDominanten_US
dc.subject.otherHumansen_US
dc.subject.otherCytokinesen_US
dc.titleClinical features of candidiasis in patients with inherited interleukin 12 receptor β1 deficiencyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/cid/cit722en_US
dc.identifier.scopus84891754308-
dc.identifier.isi000329131300012-
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dc.description.lastpage213en_US
dc.description.firstpage204en_US
dc.relation.volume58en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
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dc.description.numberofpages9en_US
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dc.contributor.wosstandardWOS:Ouederni, M-
dc.contributor.wosstandardWOS:Sanal, O-
dc.contributor.wosstandardWOS:Ikinciogullari, A-
dc.contributor.wosstandardWOS:Tezcan, I-
dc.contributor.wosstandardWOS:Dogu, F-
dc.contributor.wosstandardWOS:Sologuren, I-
dc.contributor.wosstandardWOS:Pedraza-Sanchez, S-
dc.contributor.wosstandardWOS:Keser, M-
dc.contributor.wosstandardWOS:Tanir, G-
dc.contributor.wosstandardWOS:Nieuwhof, C-
dc.contributor.wosstandardWOS:Colino, E-
dc.contributor.wosstandardWOS:Kumararatne, D-
dc.contributor.wosstandardWOS:Levy, J-
dc.contributor.wosstandardWOS:Kutukculer, N-
dc.contributor.wosstandardWOS:Aytekin, C-
dc.contributor.wosstandardWOS:Herrera-Ramos, E-
dc.contributor.wosstandardWOS:Bhatti, M-
dc.contributor.wosstandardWOS:Karaca, N-
dc.contributor.wosstandardWOS:Barbouche, R-
dc.contributor.wosstandardWOS:Broides, A-
dc.contributor.wosstandardWOS:Goudouris, E-
dc.contributor.wosstandardWOS:Jose, LF-
dc.contributor.wosstandardWOS:Parvaneh, N-
dc.contributor.wosstandardWOS:Reisli, I-
dc.contributor.wosstandardWOS:Strickler, A-
dc.contributor.wosstandardWOS:Shcherbina, A-
dc.contributor.wosstandardWOS:Somer, A-
dc.contributor.wosstandardWOS:Segal, A-
dc.contributor.wosstandardWOS:Angel-Moreno, A-
dc.contributor.wosstandardWOS:Lezana-Fernandez, JL-
dc.contributor.wosstandardWOS:Bejaoui, M-
dc.contributor.wosstandardWOS:Bobadilla-Del Valle, M-
dc.contributor.wosstandardWOS:Kachboura, S-
dc.contributor.wosstandardWOS:Sentongo, T-
dc.contributor.wosstandardWOS:Ben-Mustapha, I-
dc.contributor.wosstandardWOS:Bustamante, J-
dc.contributor.wosstandardWOS:Picard, C-
dc.contributor.wosstandardWOS:Puel, A-
dc.contributor.wosstandardWOS:Boisson-Dupuis, S-
dc.contributor.wosstandardWOS:Abel, L-
dc.contributor.wosstandardWOS:Casanova, JL-
dc.contributor.wosstandardWOS:Rodriguez-Gallego, C-
dc.date.coverdateEnero 2014en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr5,132-
dc.description.jcr8,886-
dc.description.sjrqQ1-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-4344-8644-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez Gallego, José Carlos-
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