Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48609
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dc.contributor.authorSuárez-Lorenzo, I.en_US
dc.contributor.authorDe Castro, F. Rodríguezen_US
dc.contributor.authorCruz-Niesvaara, D.en_US
dc.contributor.authorHerrera-Ramos, E.en_US
dc.contributor.authorRodríguez-Gallego, C.en_US
dc.contributor.authorCarrillo-Díaz, T.en_US
dc.date.accessioned2018-11-23T23:20:59Z-
dc.date.available2018-11-23T23:20:59Z-
dc.date.issued2018en_US
dc.identifier.issn2045-7022en_US
dc.identifier.urihttp://hdl.handle.net/10553/48609-
dc.description.abstractBackground and objectiveSevere alpha1 antitrypsin deficiency has been clearly associated with pulmonary emphysema, but its relationship with bronchial asthma remains controversial. Some deficient alpha 1 antitrypsin (AAT) genotypes seem to be associated with asthma development. The objective of this study was to analyze the distribution of AAT genotypes in asthmatic patients allergic to house dust mites (HDM), and to asses a possible association between these genotypes and severe asthma.MethodsA cross-sectional cohort study of 648 patients with HDM allergic asthma was carried out. Demographic, clinical and analytical variables were collected. PI*S and PI*Z AAT deficient alleles of the SERPINA1 gene were assayed by real-time PCR.ResultsAsthma was intermittent in 253 patients and persistent in 395 patients (246 mild, 101 moderate and 48 severe). One hundred and forty-five asthmatic patients (22.4%) with at least one mutated allele (S or Z) were identified. No association between the different genotypes and asthma severity was found. No significant differences in all clinical and functional tests, as well as nasal eosinophils, IgA and IgE serum levels were observed. Peripheral eosinophils were significantly lower in patients with the PI*MS genotype (p=0.0228). Neither association between deficient AAT genotypes or serum ATT deficiency (AATD) and development of severe asthma, or correlation between ATT levels and FEV1 was observed.ConclusionIn conclusion, the distribution of AAT genotypes in HDM allergic asthmatic patients did not differ from those found in Spanish population. Neither severe ATTD or deficient AAT genotypes appear to confer different clinical expression of asthma.en_US
dc.languageengen_US
dc.relationNeuroprotección Por Bloqueo de la Capacidad de Transactivadora Nf-Kb y Factores Relacionados.en_US
dc.relation.ispartofClinical and Translational Allergyen_US
dc.sourceClinical and Translational Allergy [ISSN 2045-7022], v. 8, 44en_US
dc.subject320508 Enfermedades pulmonaresen_US
dc.subject.otherAlpha 1 antitrypsinen_US
dc.subject.otherAlpha 1 antitrypsin deficiencyen_US
dc.subject.otherHouse dust mitesen_US
dc.subject.otherAsthmaen_US
dc.subject.otherAllergyen_US
dc.titleAlpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mitesen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s13601-018-0231-x
dc.identifier.scopus85056254819
dc.contributor.authorscopusid56529544100
dc.contributor.authorscopusid26425794500
dc.contributor.authorscopusid55520041500
dc.contributor.authorscopusid36952964800
dc.contributor.authorscopusid6602114379
dc.contributor.authorscopusid6602765567
dc.identifier.issue44-
dc.relation.volume8-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptPatología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptFarmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptPatología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez De Castro, Felipe Carlos B.-
crisitem.author.fullNameRodríguez Gallego, José Carlos-
crisitem.author.fullNameCarrillo Díaz, Teresa-
crisitem.author.departamentoCiencias Médicas y Quirúrgicas-
crisitem.author.departamentoCiencias Médicas y Quirúrgicas-
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