Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48537
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dc.contributor.authorLupiola Gómez, Pablo Antonioen_US
dc.contributor.authorGonzález-Lama, Z.en_US
dc.contributor.authorTejedor-Junco, M. T.en_US
dc.contributor.authorGonzález-Martín, M.en_US
dc.contributor.authorMartín Barrasa, José Luisen_US
dc.date.accessioned2018-11-23T22:41:34Z-
dc.date.available2018-11-23T22:41:34Z-
dc.date.issued2003en_US
dc.identifier.issn0008-4166en_US
dc.identifier.urihttp://hdl.handle.net/10553/48537-
dc.description.abstractThe contribution of β-lactamase production to β-lactam antibiotic resistance was examined in an Aeromonas caviae mutant strain, selected in vitro by cefotaxime and derived from a wild-type strain isolated in our laboratory from crude sewage. Both strains produced β-lactamase. The mutant strain (AC7m) produced β-lactamase constitutively, in contrast to the parental strain (AC7), which was inducible by cefoxitin. AC7m was regarded as a mutant from AC7, which over-expressed β-lactamase. The mutant strain showed a remarkable reduction in sensitivity to most of the β-lactam antibiotics tested, such as (i) aminopenicillins and their combinations with clavulanic acid and sulbactam, (ii) carboxypenicillins, (iii) ureidopenicillins, and (iv) cephalosporins. This strain remained susceptible to ceftazidime, imipenem, and aztreonam. Isoelectric focusing of sonic extracts revealed that both strains AC7 and AC7m shared a common major β-lactamase band at pI 6.5. The plasmid DNA assays showed that the β-lactamases expressed by each A. caviae strain were chromosomally encoded. Based on substrate and inhibitor profiles determined in sonic extracts for AC7 and AC7m, the enzymes displayed on isoelectric focusing at pI 6.5 were assigned to chromosomal Group 1 β-lactamases. Imipenem would therefore be the appropriate choice for therapy of infections caused by A. caviae β-lactamase over-expressing mutants.en_US
dc.languageengen_US
dc.relation.ispartofCanadian journal of microbiology (Print)en_US
dc.sourceCanadian journal of microbiology [ISSN 0008-4166], v. 49 (3), p. 207-215en_US
dc.subject3109 Ciencias veterinariasen_US
dc.subject.otherAeromonas caviaeen_US
dc.subject.otherβ-lactamasesen_US
dc.subject.otherAntibiotic resistanceen_US
dc.titleGroup 1 β-lactamases of Aeromonas caviae and their resistance to β-lactam antibioticsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1139/w03-030en_US
dc.identifier.pmid49-
dc.identifier.scopus0037534230-
dc.identifier.scopus2-s2.0-0037534230-
dc.identifier.isi000183010400007-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.authorscopusid6507958235-
dc.contributor.authorscopusid56616723200-
dc.contributor.authorscopusid6603353402-
dc.contributor.authorscopusid7102664348-
dc.contributor.authorscopusid6506508811-
dc.description.lastpage215en_US
dc.identifier.issue3-
dc.description.firstpage207en_US
dc.relation.volume49en_US
dc.investigacionCienciasen_US
dc.type2Artículoen_US
dc.contributor.daisngid5555477-
dc.contributor.daisngid5578787-
dc.contributor.daisngid2312733-
dc.contributor.daisngid4601864-
dc.contributor.daisngid3848318-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Lupiola-Gomez, PA-
dc.contributor.wosstandardWOS:Gonzalez-Lama, Z-
dc.contributor.wosstandardWOS:Tejedor-Junco, MT-
dc.contributor.wosstandardWOS:Gonzalez-Martin, M-
dc.contributor.wosstandardWOS:Martin-Barrasa, JL-
dc.date.coverdateMarzo 2003en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.jcr1,094
dc.description.jcrqQ3
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Trypanosomosis, Resistencia a Antibióticos y Medicina Animal-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Trypanosomosis, Resistencia a Antibióticos y Medicina Animal-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Trypanosomosis, Resistencia a Antibióticos y Medicina Animal-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUSA-ONE HEALTH 2.-Sanidad Animal de la Acuicultura y Especies Silvestres, Enfermedades Infecciosas y Seguridad Alimentaria-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0002-4457-2321-
crisitem.author.orcid0000-0003-2387-1426-
crisitem.author.orcid0000-0002-4457-2321-
crisitem.author.orcid0000-0002-3280-9838-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameLupiola Gómez, Pablo Antonio-
crisitem.author.fullNameGonzález Martín, Margarita Rosa-
crisitem.author.fullNameTejedor Junco, María Teresa-
crisitem.author.fullNameGonzález Martín, Margarita Rosa-
crisitem.author.fullNameMartín Barrasa, José Luis-
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