Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/48448
Título: Different frequency of cilia with transposition in human nasal and bronchial mucosa. A case of acquired ciliary dyskinesia
Autores/as: Bautista Harris, Guillermina 
Rodríguez Bermejo, Juan Carlos 
Castillo Suarez, Miguel
Clasificación UNESCO: 32 Ciencias médicas
3205 Medicina interna
Palabras clave: Acquired ciliary dyskinesia
Bronchial cilia
Nasal cilia
Spermatozoan flagella
Transposition
Fecha de publicación: 2000
Publicación seriada: Virchows Archiv 
Resumen: Nasal and bronchial cilia and spermatozoa of a patient with a high clinical suspicion of a ciliary dyskinesia syndrome were ultrastructurally studied and quantified. Defective cilia showed two types of axonemal patterns: 9d+0s and 8d+1d. Of these, 9d+0s cilia prevailed in the proximal region, whereas 8d+1d prevailed in the distal region. Translocation of a peripheral doublet to the central position occurred at the middle region of cilia lacking the central pair, probably to compensate for its absence. Quantitative analysis showed that the percentages of anomalous cilia were 5.32+/-0.93 in nasal samples and 43.17+/-2.34 in bronchial samples. Spermatozoa without the central pair or with a translocated microtubular doublet were rarely observed, but a variety of nonspecific defects were seen. Even though transposition is generally considered to be an inherited ciliary defect and one of the causes of primary ciliary dyskinesia, in this case quantitative ultrastructural analysis and clinical data indicate that this is an acquired ciliary defect.
URI: http://hdl.handle.net/10553/48448
ISSN: 0945-6317
DOI: 10.1007/s004280000221
Fuente: Virchows Archiv[ISSN 0945-6317],v. 437, p. 325-330
Colección:Artículos
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