Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48254
DC FieldValueLanguage
dc.contributor.authorDiaz, L. E.en_US
dc.contributor.authorChuan, Y. C.en_US
dc.contributor.authorLewitt, M.en_US
dc.contributor.authorFernandez-Perez, L.en_US
dc.contributor.authorCarrasco-Rodríguez, S.en_US
dc.contributor.authorSanchez-Gomez, M.en_US
dc.contributor.authorFlores-Morales, A.en_US
dc.date.accessioned2018-11-23T20:11:06Z-
dc.date.available2018-11-23T20:11:06Z-
dc.date.issued2007en_US
dc.identifier.issn1360-9947en_US
dc.identifier.urihttp://hdl.handle.net/10553/48254-
dc.description.abstractChoriocarcinoma is a highly malignant tumor that can arise from trophoblasts of any type of gestational event but most often from complete hydatidiform mole. IGF-II plays a fundamental role in placental development and may play a role in gestational trophoblastic diseases. Several studies have shown that IGF-II is expressed at high levels in hydatidiform moles and choriocarcinoma tissues; however, conflicting data exist on how IGF-II regulates the behaviour of choriocarcinoma cells. The purpose of this study was to determine the contribution of the receptors for IGF-I and insulin to the actions of IGF-II on the regulation of choriocarcinoma cells metastasis. An Immuno Radio Metric Assay was used to analyse the circulating and tissue levels of IGF-I and IGF-II in 24 cases of hydatidiform mole, two cases of choriocarcinoma and eight cases of spontaneous abortion at the same gestational age. The JEG-3 choriocarcinoma cell line was used to investigate the role of IGF-II in the regulation of cell invasion. We found that mole and choriocarcinoma tissue express high levels of IGF-II compared to first trimester placenta. Both IGF-I and IGF-II regulate choriocarcinoma cell invasion in a dose dependent manner but through a different mechanism. IGF-II effects involve the activation of the InsR while IGF-I uses the IGF-IR. The positive effects of IGF-II on invasion are the result of enhanced cell adhesion and chemotaxis (specifically towards collagen IV). The actions of IGF-II but not those of IGF-I were sensitive to inhibition by the insulin receptor inhibitor HNMPA(AM)3. Our results demonstrate that the insulin receptor regulates choriocarcinoma cell invasion. © The Author 2007.en_US
dc.languagespaen_US
dc.publisher1360-9947
dc.relationMecanismos Moleculares y Celulares de Señalización Intracelular en Respuesta A la Hormona de Crecimiento Humana: la Vía Jak (Janus Kinase) Stat (Signal Transducer And Activator Of Transcription) Coen_US
dc.relation.ispartofMolecular Human Reproductionen_US
dc.sourceMolecular Human Reproduction[ISSN 1360-9947],v. 13, p. 567-576en_US
dc.titleIGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptoren_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/molehr/gam039en_US
dc.identifier.scopus34547838385-
dc.contributor.authorscopusid57195940729-
dc.contributor.authorscopusid57210120489-
dc.contributor.authorscopusid8325409300-
dc.contributor.authorscopusid7004229644-
dc.contributor.authorscopusid6506777525-
dc.contributor.authorscopusid6506731094-
dc.contributor.authorscopusid7003610338-
dc.contributor.authorscopusid57203543352-
dc.description.lastpage576en_US
dc.description.firstpage567en_US
dc.relation.volume13en_US
dc.type2Artículoen_US
dc.date.coverdateAgosto 2007en_US
dc.identifier.ulpgces
dc.description.jcr2,871
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptFarmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptCiencias Clínicas-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.orcid0000-0002-0828-8921-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameFernández Pérez, Leandro Fco-
crisitem.author.fullNameFlores Morales, Amilcar-
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