Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/48250
Campo DC Valoridioma
dc.contributor.authorZadjali, Fahaden_US
dc.contributor.authorSantana-Farre, Ruymanen_US
dc.contributor.authorVesterlund, Mattiasen_US
dc.contributor.authorCarow, Beriten_US
dc.contributor.authorMirecki-Garrido, Mercedesen_US
dc.contributor.authorHernandez-Hernandez, Ireneen_US
dc.contributor.authorFlodström-Tullberg, Malinen_US
dc.contributor.authorParini, Paoloen_US
dc.contributor.authorRottenberg, Martinen_US
dc.contributor.authorNorstedt, Gunnaren_US
dc.contributor.authorFernandez-Perez, Leandroen_US
dc.contributor.authorFlores-Morales, Amilcaren_US
dc.contributor.otherHernandez, Irene-
dc.contributor.otherFernandez-Perez, Leandro-
dc.contributor.otherMirecki-Garrido, Mercedes-
dc.contributor.otherZADJALI, FAHAD-
dc.contributor.otherFlodstrom Tullberg, Malin-
dc.contributor.otherVesterlund, Mattias-
dc.contributor.otherNorstedt, Gunnar-
dc.contributor.otherCarow, Berit-
dc.date.accessioned2018-11-23T20:09:06Z-
dc.date.available2018-11-23T20:09:06Z-
dc.date.issued2012en_US
dc.identifier.issn0892-6638en_US
dc.identifier.urihttp://hdl.handle.net/10553/48250-
dc.description.abstractHepatic steatosis is a prominent feature in patients with growth hormone (GH) deficiency. The ubiquitin ligase SOCS2 attenuates hepatic GH signaling by inhibiting the Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5b (STAT5b) axis. Here, we investigated the role of SOCS2 in the development of diet-induced hepatic steatosis and insulin resistance. SOCS2-knockout (SOCS2(-/-)) mice and wild-type littermates were fed for 4 mo with control or high-fat diet, followed by assessment of insulin sensitivity, hepatic lipid content, and expression of inflammatory cytokines. SOCS2(-/-) mice exhibited increased hepatic TG secretion by 77.6% (P<0.001) as compared with wild-type control mice and were protected from high-fat-diet (HFD)-induced hepatic steatosis, showing 49.3% (P<0.01) reduction in liver TG levels compared to HFD-fed wild-type littermates. In contrast, we found that HFD-triggered attenuation of systemic insulin sensitivity was more marked in SOCS2(-/-) mice. Livers from the HFD-fed SOCS2(-/-) mice showed increased NF-kappa B activity as well as elevated expression of genes for the inflammatory cytokines IFN-gamma and IL-6. An inhibitory role of SOCS2 on Toll-like receptor 4 signaling was demonstrated in macrophages obtained from the SOCS2(-/-) and wild-type mice. This study identified SOCS2 as an important regulator of hepatic homeostasis under conditions of high-fat dietary stress.-Zadjali, F., Santana-Farre, R., Vesterlund, M., Carow, B., Mirecki-Garrido, M., Hernandez-Hernandez, I., Flodstrom-Tullberg, M., Parini, P., Rottenberg, M., Norstedt, G., Fernandez-Perez, L., Flores-Morales, A. SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice.en_US
dc.languageengen_US
dc.relationEstudio Funcional y Molecular de Las Proteínas Socs en Un Modelo de Resistencia Hepática A Insulina.en_US
dc.relation.ispartofFASEB Journalen_US
dc.sourceFaseb Journal[ISSN 0892-6638],v. 26 (8), p. 3282-3291en_US
dc.subject32 Ciencias médicasen_US
dc.subject2302 Bioquímicaen_US
dc.subject.otherLacking Suppressoren_US
dc.subject.otherLiveren_US
dc.subject.otherDeficiencyen_US
dc.subject.otherObesityen_US
dc.subject.otherSteatohepatitisen_US
dc.subject.otherHyperlipidemiaen_US
dc.subject.otherExpressionen_US
dc.subject.otherProteinsen_US
dc.titleSOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed miceen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1096/fj.12-205583en_US
dc.identifier.scopus84864665833-
dc.identifier.isi000307162800019-
dcterms.isPartOfFaseb Journal-
dcterms.sourceFaseb Journal[ISSN 0892-6638],v. 26 (8), p. 3282-3291-
dc.contributor.authorscopusid23011004900-
dc.contributor.authorscopusid15830358800-
dc.contributor.authorscopusid37091811900-
dc.contributor.authorscopusid35572948200-
dc.contributor.authorscopusid55221793700-
dc.contributor.authorscopusid57201434068-
dc.contributor.authorscopusid8570437300-
dc.contributor.authorscopusid6701425383-
dc.contributor.authorscopusid7003474126-
dc.contributor.authorscopusid7006397634-
dc.contributor.authorscopusid6506777525-
dc.contributor.authorscopusid57203543352-
dc.contributor.authorscopusid57203543358-
dc.description.lastpage3291en_US
dc.description.firstpage3282en_US
dc.relation.volume26en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000307162800019-
dc.contributor.daisngid1793904-
dc.contributor.daisngid3808417-
dc.contributor.daisngid2087322-
dc.contributor.daisngid3320258-
dc.contributor.daisngid4588303-
dc.contributor.daisngid13190735-
dc.contributor.daisngid462854-
dc.contributor.daisngid641834-
dc.contributor.daisngid199914-
dc.contributor.daisngid214168-
dc.contributor.daisngid178539-
dc.contributor.daisngid795544-
dc.contributor.daisngid617657-
dc.identifier.investigatorRIDN-7551-2016-
dc.identifier.investigatorRIDH-1493-2015-
dc.identifier.investigatorRIDH-6075-2015-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages10en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Zadjali, F-
dc.contributor.wosstandardWOS:Santana-Farre, R-
dc.contributor.wosstandardWOS:Vesterlund, M-
dc.contributor.wosstandardWOS:Carow, B-
dc.contributor.wosstandardWOS:Mirecki-Garrido, M-
dc.contributor.wosstandardWOS:Hernandez-Hernandez, I-
dc.contributor.wosstandardWOS:Flodstrom-Tullberg, M-
dc.contributor.wosstandardWOS:Parini, P-
dc.contributor.wosstandardWOS:Rottenberg, M-
dc.contributor.wosstandardWOS:Norstedt, G-
dc.contributor.wosstandardWOS:Fernandez-Perez, L-
dc.contributor.wosstandardWOS:Flores-Morales, A-
dc.date.coverdateAgosto 2012en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr3,071-
dc.description.jcr5,704-
dc.description.sjrqQ1-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0003-0488-6307-
crisitem.author.orcid0000-0001-7174-7599-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.orcid0000-0002-0828-8921-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameDe Mirecki Garrido, Mercedes-
crisitem.author.fullNameHernández Hernández,Irene-
crisitem.author.fullNameFernández Pérez, Leandro Francisco-
crisitem.author.fullNameFlores Morales,Amilcar-
crisitem.project.principalinvestigatorFernández Pérez, Leandro Francisco-
Colección:Artículos
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