Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/48250
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zadjali, Fahad | en_US |
dc.contributor.author | Santana-Farre, Ruyman | en_US |
dc.contributor.author | Vesterlund, Mattias | en_US |
dc.contributor.author | Carow, Berit | en_US |
dc.contributor.author | Mirecki-Garrido, Mercedes | en_US |
dc.contributor.author | Hernandez-Hernandez, Irene | en_US |
dc.contributor.author | Flodström-Tullberg, Malin | en_US |
dc.contributor.author | Parini, Paolo | en_US |
dc.contributor.author | Rottenberg, Martin | en_US |
dc.contributor.author | Norstedt, Gunnar | en_US |
dc.contributor.author | Fernandez-Perez, Leandro | en_US |
dc.contributor.author | Flores-Morales, Amilcar | en_US |
dc.contributor.other | Hernandez, Irene | - |
dc.contributor.other | Fernandez-Perez, Leandro | - |
dc.contributor.other | Mirecki-Garrido, Mercedes | - |
dc.contributor.other | ZADJALI, FAHAD | - |
dc.contributor.other | Flodstrom Tullberg, Malin | - |
dc.contributor.other | Vesterlund, Mattias | - |
dc.contributor.other | Norstedt, Gunnar | - |
dc.contributor.other | Carow, Berit | - |
dc.date.accessioned | 2018-11-23T20:09:06Z | - |
dc.date.available | 2018-11-23T20:09:06Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.issn | 0892-6638 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/48250 | - |
dc.description.abstract | Hepatic steatosis is a prominent feature in patients with growth hormone (GH) deficiency. The ubiquitin ligase SOCS2 attenuates hepatic GH signaling by inhibiting the Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5b (STAT5b) axis. Here, we investigated the role of SOCS2 in the development of diet-induced hepatic steatosis and insulin resistance. SOCS2-knockout (SOCS2(-/-)) mice and wild-type littermates were fed for 4 mo with control or high-fat diet, followed by assessment of insulin sensitivity, hepatic lipid content, and expression of inflammatory cytokines. SOCS2(-/-) mice exhibited increased hepatic TG secretion by 77.6% (P<0.001) as compared with wild-type control mice and were protected from high-fat-diet (HFD)-induced hepatic steatosis, showing 49.3% (P<0.01) reduction in liver TG levels compared to HFD-fed wild-type littermates. In contrast, we found that HFD-triggered attenuation of systemic insulin sensitivity was more marked in SOCS2(-/-) mice. Livers from the HFD-fed SOCS2(-/-) mice showed increased NF-kappa B activity as well as elevated expression of genes for the inflammatory cytokines IFN-gamma and IL-6. An inhibitory role of SOCS2 on Toll-like receptor 4 signaling was demonstrated in macrophages obtained from the SOCS2(-/-) and wild-type mice. This study identified SOCS2 as an important regulator of hepatic homeostasis under conditions of high-fat dietary stress.-Zadjali, F., Santana-Farre, R., Vesterlund, M., Carow, B., Mirecki-Garrido, M., Hernandez-Hernandez, I., Flodstrom-Tullberg, M., Parini, P., Rottenberg, M., Norstedt, G., Fernandez-Perez, L., Flores-Morales, A. SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice. | en_US |
dc.language | eng | en_US |
dc.relation | Estudio Funcional y Molecular de Las Proteínas Socs en Un Modelo de Resistencia Hepática A Insulina. | en_US |
dc.relation.ispartof | FASEB Journal | en_US |
dc.source | Faseb Journal[ISSN 0892-6638],v. 26 (8), p. 3282-3291 | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject | 2302 Bioquímica | en_US |
dc.subject.other | Lacking Suppressor | en_US |
dc.subject.other | Liver | en_US |
dc.subject.other | Deficiency | en_US |
dc.subject.other | Obesity | en_US |
dc.subject.other | Steatohepatitis | en_US |
dc.subject.other | Hyperlipidemia | en_US |
dc.subject.other | Expression | en_US |
dc.subject.other | Proteins | en_US |
dc.title | SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1096/fj.12-205583 | en_US |
dc.identifier.scopus | 84864665833 | - |
dc.identifier.isi | 000307162800019 | - |
dcterms.isPartOf | Faseb Journal | - |
dcterms.source | Faseb Journal[ISSN 0892-6638],v. 26 (8), p. 3282-3291 | - |
dc.contributor.authorscopusid | 23011004900 | - |
dc.contributor.authorscopusid | 15830358800 | - |
dc.contributor.authorscopusid | 37091811900 | - |
dc.contributor.authorscopusid | 35572948200 | - |
dc.contributor.authorscopusid | 55221793700 | - |
dc.contributor.authorscopusid | 57201434068 | - |
dc.contributor.authorscopusid | 8570437300 | - |
dc.contributor.authorscopusid | 6701425383 | - |
dc.contributor.authorscopusid | 7003474126 | - |
dc.contributor.authorscopusid | 7006397634 | - |
dc.contributor.authorscopusid | 6506777525 | - |
dc.contributor.authorscopusid | 57203543352 | - |
dc.contributor.authorscopusid | 57203543358 | - |
dc.description.lastpage | 3291 | en_US |
dc.description.firstpage | 3282 | en_US |
dc.relation.volume | 26 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.wos | WOS:000307162800019 | - |
dc.contributor.daisngid | 1793904 | - |
dc.contributor.daisngid | 3808417 | - |
dc.contributor.daisngid | 2087322 | - |
dc.contributor.daisngid | 3320258 | - |
dc.contributor.daisngid | 4588303 | - |
dc.contributor.daisngid | 13190735 | - |
dc.contributor.daisngid | 462854 | - |
dc.contributor.daisngid | 641834 | - |
dc.contributor.daisngid | 199914 | - |
dc.contributor.daisngid | 214168 | - |
dc.contributor.daisngid | 178539 | - |
dc.contributor.daisngid | 795544 | - |
dc.contributor.daisngid | 617657 | - |
dc.identifier.investigatorRID | N-7551-2016 | - |
dc.identifier.investigatorRID | H-1493-2015 | - |
dc.identifier.investigatorRID | H-6075-2015 | - |
dc.identifier.investigatorRID | No ID | - |
dc.identifier.investigatorRID | No ID | - |
dc.identifier.investigatorRID | No ID | - |
dc.identifier.investigatorRID | No ID | - |
dc.identifier.investigatorRID | No ID | - |
dc.description.numberofpages | 10 | en_US |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:Zadjali, F | - |
dc.contributor.wosstandard | WOS:Santana-Farre, R | - |
dc.contributor.wosstandard | WOS:Vesterlund, M | - |
dc.contributor.wosstandard | WOS:Carow, B | - |
dc.contributor.wosstandard | WOS:Mirecki-Garrido, M | - |
dc.contributor.wosstandard | WOS:Hernandez-Hernandez, I | - |
dc.contributor.wosstandard | WOS:Flodstrom-Tullberg, M | - |
dc.contributor.wosstandard | WOS:Parini, P | - |
dc.contributor.wosstandard | WOS:Rottenberg, M | - |
dc.contributor.wosstandard | WOS:Norstedt, G | - |
dc.contributor.wosstandard | WOS:Fernandez-Perez, L | - |
dc.contributor.wosstandard | WOS:Flores-Morales, A | - |
dc.date.coverdate | Agosto 2012 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.sjr | 3,071 | - |
dc.description.jcr | 5,704 | - |
dc.description.sjrq | Q1 | - |
dc.description.jcrq | Q1 | - |
dc.description.scie | SCIE | - |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.project.principalinvestigator | Fernández Pérez, Leandro Francisco | - |
crisitem.author.dept | GIR IUIBS: Medio Ambiente y Salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.orcid | 0000-0003-0488-6307 | - |
crisitem.author.orcid | 0000-0001-7174-7599 | - |
crisitem.author.orcid | 0000-0001-7802-465X | - |
crisitem.author.orcid | 0000-0002-0828-8921 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | De Mirecki Garrido, Mercedes | - |
crisitem.author.fullName | Hernández Hernández,Irene | - |
crisitem.author.fullName | Fernández Pérez, Leandro Francisco | - |
crisitem.author.fullName | Flores Morales,Amilcar | - |
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