Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/48248
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dc.contributor.authorQuintana-Espinoza, Patriciaen_US
dc.contributor.authorGarcía-Luis, Jonayen_US
dc.contributor.authorAmesty, Ángelen_US
dc.contributor.authorMartín Rodríguez, Patriciaen_US
dc.contributor.authorLorenzo-Castrillejo, Isabelen_US
dc.contributor.authorRavelo, Angel G.en_US
dc.contributor.authorFernández Pérez, Leandro Fcoen_US
dc.contributor.authorMachín, Félixen_US
dc.contributor.authorEstévez-Braun, Anaen_US
dc.contributor.otherEstevez-Braun, Ana-
dc.contributor.otherPatricia, Martin Rodriguez-
dc.contributor.otherMachin, Felix-
dc.contributor.otherFernandez-Perez, Leandro-
dc.contributor.otherDiaz-Chico, Juan-
dc.date.accessioned2018-11-23T20:08:06Z-
dc.date.available2018-11-23T20:08:06Z-
dc.date.issued2013en_US
dc.identifier.issn0968-0896en_US
dc.identifier.urihttp://hdl.handle.net/10553/48248-
dc.description.abstractA series of arylnaphthalimides were designed and synthesized to overcome the dose-limiting cytotoxicity of N-acetylated metabolites arising from amonafide, the prototypical antitumour naphthalimide whose biomedical properties have been related to its ability to intercalate the DNA and poison the enzyme Topoisomerase II. Thus, these arylnaphthalimides were first evaluated for their antiproliferative activity against two tumour cell lines and for their antitopoisomerase II in vitro activities, together with their ability to intercalate the DNA in vitro and also through docking modelization. Then, the well-known DNA damage response in Saccharomyces cerevisiae was employed to critically evaluate whether these novel compounds can damage the DNA in vivo. By performing all these assays we conclude that the 5-arylsubstituted naphthalimides not only keep but also improve amonafide's biological activities.en_US
dc.languageengen_US
dc.relation.ispartofBioorganic and Medicinal Chemistryen_US
dc.sourceBioorganic & Medicinal Chemistry[ISSN 0968-0896],v. 21 (21), p. 6484-6495en_US
dc.subject32 Ciencias médicasen_US
dc.subject2302 Bioquímicaen_US
dc.subject.otherTopoisomerase-Iien_US
dc.subject.otherHomologous Recombinationen_US
dc.subject.otherBiological-Activityen_US
dc.subject.otherAnticancer Agentsen_US
dc.subject.otherAmonafideen_US
dc.subject.otherInhibitorsen_US
dc.subject.otherCleavageen_US
dc.subject.otherAnalogsen_US
dc.subject.otherDerivativesen_US
dc.subject.otherToxicityen_US
dc.titleSynthesis and study of antiproliferative, antitopoisomerase II, DNA-intercalating and DNA-damaging activities of arylnaphthalimidesen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bmc.2013.08.039en_US
dc.identifier.scopus84885173293-
dc.identifier.isi000325164500023-
dcterms.isPartOfBioorganic & Medicinal Chemistry-
dcterms.sourceBioorganic & Medicinal Chemistry[ISSN 0968-0896],v. 21 (21), p. 6484-6495-
dc.contributor.authorscopusid55853678300-
dc.contributor.authorscopusid54787576800-
dc.contributor.authorscopusid14024036100-
dc.contributor.authorscopusid36604772400-
dc.contributor.authorscopusid35339523900-
dc.contributor.authorscopusid11142332700-
dc.contributor.authorscopusid6506777525-
dc.contributor.authorscopusid6602804373-
dc.contributor.authorscopusid6701825073-
dc.description.lastpage6495en_US
dc.description.firstpage6484en_US
dc.relation.volume21en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000325164500023-
dc.contributor.daisngid10377211-
dc.contributor.daisngid4016259-
dc.contributor.daisngid3211275-
dc.contributor.daisngid3922169-
dc.contributor.daisngid4720340-
dc.contributor.daisngid163601-
dc.contributor.daisngid795544-
dc.contributor.daisngid1106759-
dc.contributor.daisngid425077-
dc.identifier.investigatorRIDA-8122-2015-
dc.identifier.investigatorRIDH-3238-2015-
dc.identifier.investigatorRIDK-6569-2017-
dc.identifier.investigatorRIDH-1493-2015-
dc.identifier.investigatorRIDH-1527-2015-
dc.description.numberofpages12en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Quintana-Espinoza, P-
dc.contributor.wosstandardWOS:Garcia-Luis, J-
dc.contributor.wosstandardWOS:Amesty, A-
dc.contributor.wosstandardWOS:Martin-Rodriguez, P-
dc.contributor.wosstandardWOS:Lorenzo-Castrillejo, I-
dc.contributor.wosstandardWOS:Ravelo, AG-
dc.contributor.wosstandardWOS:Fernandez-Perez, L-
dc.contributor.wosstandardWOS:Machin, F-
dc.contributor.wosstandardWOS:Estevez-Braun, A-
dc.date.coverdateNoviembre 2013en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,063-
dc.description.jcr2,951-
dc.description.sjrqQ1-
dc.description.jcrqQ2-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-2378-3242-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMartín Rodríguez, Patricia-
crisitem.author.fullNameFernández Pérez, Leandro Francisco-
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