Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/48219
Campo DC | Valor | idioma |
---|---|---|
dc.contributor.author | Estévez-González, María Dolores | en_US |
dc.contributor.author | Saavedra Santana, Pedro | en_US |
dc.contributor.author | López Ríos,Laura | en_US |
dc.contributor.author | Chirino, Ricardo | en_US |
dc.contributor.author | Cebrero-García, Elena | en_US |
dc.contributor.author | Peña-Quintana, Luis | en_US |
dc.contributor.author | Betancor-León, Pedro | en_US |
dc.date.accessioned | 2018-11-23T19:53:45Z | - |
dc.date.available | 2018-11-23T19:53:45Z | - |
dc.date.issued | 2010 | en_US |
dc.identifier.issn | 0250-6807 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/48219 | - |
dc.description.abstract | Background: This study aimed to examine the changes in serum lipids in children with mild hypercholesterolemia after the use of skim milk or olive-oil-enriched skim milk in their diet and the modulation of lipid levels by the Taq 1B polymorphism in the cholesteryl-ester transfer protein gene. Methods: Thirty-six prepubertal children with mild hypercholesterolemia were randomly assigned in a crossover design into 2 groups of 16 and 20 individuals. Both groups received, in sequential inverse order, the 2 types of milk for 2 periods of 6 weeks. Results: Carriers of at least 1 B2 allele had an adjusted basal HDL cholesterol level significantly higher than children with the B1B1 genotype (1.291 mmol/l, 95% CI: 1.184-1.397, vs. 1.082 mmol/l, 95% CI: 0.931-1.233; p = 0.027). In contrast, there were no significant differences in the adjusted basal levels of apolipoprotein A-I (B2 carriers: 1.292 g/l, 95% CI: 1.218-1.367; B1B1 genotype: 1.215 g/l, 95% CI: 1.109-1.320; p = 0.223). The intake of olive-oil-enriched skim milk caused significant increases in HDL cholesterol and apolipoprotein A-I, both in B2 (0.089 mmol/l, 95% CI: 0.032-0.146, p = 0.005; 0.55 g/l, 95% CI: 0.012-0.098; p = 0.018) and in B1B1 carriers (0.179 mmol/l, 95% CI: 0.096-0.262; p < 0.001; and 0.095 g/l, 95% CI: 0.032-0.157; p = 0.003). This increase in HDL cholesterol was significantly higher in the B1B1 group (p = 0.049). Conclusion: The consumption of skim milk enriched with olive oil increases the HDL cholesterol and apolipoprotein A-I levels in children with hypercholesterolemia, this effect being more intense in carriers of the B1B1 genotype. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Annals of Nutrition and Metabolism | en_US |
dc.source | Annals of Nutrition and Metabolism[ISSN 0250-6807],v. 56, p. 288-293 (Junio 2010) | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject | 3206 Ciencias de la nutrición | en_US |
dc.subject.other | Density-Lipoprotein Cholesterol | en_US |
dc.subject.other | Unsaturated Fatty-Acids | en_US |
dc.subject.other | Transfer Protein Gene | en_US |
dc.subject.other | Plasma-Lipid Levels | en_US |
dc.subject.other | Polygenic Hypercholesterolemia | en_US |
dc.subject.other | Risk-Factors | en_US |
dc.subject.other | Oleic-Acid | en_US |
dc.subject.other | Diet | en_US |
dc.subject.other | Adolescents | en_US |
dc.subject.other | Intervention | en_US |
dc.title | HDL cholesterol levels in children with mild hypercholesterolemia: Effect of consuming skim milk enriched with olive oil and modulation by the TAQ 1B polymorphism in the CETP gene | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1159/000290405 | en_US |
dc.identifier.scopus | 77951074213 | - |
dc.identifier.isi | 000279331000008 | - |
dc.contributor.authorscopusid | 6506688358 | - |
dc.contributor.authorscopusid | 56677724200 | - |
dc.contributor.authorscopusid | 33068166900 | - |
dc.contributor.authorscopusid | 6701324062 | - |
dc.contributor.authorscopusid | 35799552900 | - |
dc.contributor.authorscopusid | 6603266503 | - |
dc.contributor.authorscopusid | 7004366101 | - |
dc.description.lastpage | 293 | en_US |
dc.description.firstpage | 288 | en_US |
dc.relation.volume | 56 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.contributor.daisngid | 13363340 | - |
dc.contributor.daisngid | 3094556 | - |
dc.contributor.daisngid | 1964185 | - |
dc.contributor.daisngid | 880609 | - |
dc.contributor.daisngid | 14086491 | - |
dc.contributor.daisngid | 1012004 | - |
dc.contributor.daisngid | 3450288 | - |
dc.description.numberofpages | 6 | en_US |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:Estevez-Gonzalez, MD | - |
dc.contributor.wosstandard | WOS:Saavedra-Santana, P | - |
dc.contributor.wosstandard | WOS:Lopez-Rios, L | - |
dc.contributor.wosstandard | WOS:Chirino, R | - |
dc.contributor.wosstandard | WOS:Cebrero-Garcia, E | - |
dc.contributor.wosstandard | WOS:Pena-Quintana, L | - |
dc.contributor.wosstandard | WOS:Betancor-Leon, P | - |
dc.date.coverdate | Junio 2010 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.jcr | 2,173 | - |
dc.description.jcrq | Q2 | - |
dc.description.scie | SCIE | - |
item.fulltext | Sin texto completo | - |
item.grantfulltext | none | - |
crisitem.author.dept | Departamento de Enfermería | - |
crisitem.author.dept | GIR Estadística | - |
crisitem.author.dept | Departamento de Matemáticas | - |
crisitem.author.dept | GIR IUIBS: Diabetes y endocrinología aplicada | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.dept | GIR IUIBS: Nutrición | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.orcid | 0000-0003-1681-7165 | - |
crisitem.author.orcid | 0000-0002-5681-8931 | - |
crisitem.author.orcid | 0000-0001-6052-5894 | - |
crisitem.author.parentorg | Departamento de Matemáticas | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Estévez González, María Dolores | - |
crisitem.author.fullName | Saavedra Santana, Pedro | - |
crisitem.author.fullName | López Ríos,Laura | - |
crisitem.author.fullName | Chirino Godoy, Ricardo | - |
crisitem.author.fullName | Peña Quintana, Luis | - |
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