Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/47798
Campo DC Valoridioma
dc.contributor.authorSaid Quintana, Mercedesen_US
dc.contributor.authorBrouard Martín,Ignacioen_US
dc.contributor.authorQuintana, Joséen_US
dc.contributor.authorEstévez, Franciscoen_US
dc.contributor.otherBrouard, Ignacio-
dc.contributor.otherEstevez, Francisco-
dc.date.accessioned2018-11-23T16:29:58Z-
dc.date.available2018-11-23T16:29:58Z-
dc.date.issued2017en_US
dc.identifier.issn0009-2797en_US
dc.identifier.urihttp://hdl.handle.net/10553/47798-
dc.description.abstractIn this study, we investigated the effects of synthetic 3',4'-dibenzyloxyflavonol on viabilities of eight human tumor cells. It was cytotoxic against leukemia cells (HL-60, U-937, MOLT-3, K-562, NALM-6, Raji), with significant effects against P-glycoprotein-overexpressing K-562/ADR and Bcl-2-overexpressing U-937/ Bcl-2 cells, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. The IC50 value for the leukemia HL-60 cells was 0.8 +/- 0.1 mu M. This indicates a 60-fold greater toxicity than the naturally occurring flavonol quercetin. Synthetic 3',4'-dibenzyloxyflavonol induced S phase cell cycle arrest and was a potent apoptotic inducer in human leukemia cells. Cell death was (i) mediated by the activation and the cleavage of initiator and executioner caspases; (ii) prevented by the pan-caspase inhibitor z-VAD-fmk; (iii) associated with the release of cytochrome c and with the phosphorylation of members of the mitogen activated protein kinases including p38(MAPK), JNK/SAPK and ERK, and (iv) independent of the generation of reactive oxygen species. The synthetic 3',4'-dibenzyloxyflavonol is a potent cytotoxic compound against several human leukemia cells and might be useful in the development of new strategies in the fight against cancer.en_US
dc.languageengen_US
dc.relation.ispartofChemico-biological interactions (Print)en_US
dc.sourceChemico-Biological Interactions [ISSN 0009-2797],v. 268, p. 13-23en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherApoptosisen_US
dc.subject.otherCaspasesen_US
dc.subject.otherCell cycleen_US
dc.subject.otherCytotoxicityen_US
dc.subject.otherFlavonoidsen_US
dc.titleAntiproliferative activity and apoptosis induction by 3′,4′-dibenzyloxyflavonol on human leukemia cellsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.cbi.2017.02.010en_US
dc.identifier.scopus85014047866-
dc.identifier.isi000400460700002-
dcterms.isPartOfChemico-Biological Interactions-
dcterms.sourceChemico-Biological Interactions[ISSN 0009-2797],v. 268, p. 13-23-
dc.contributor.authorscopusid57193440559-
dc.contributor.authorscopusid6603470039-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7003810011-
dc.identifier.eissn1872-7786-
dc.description.lastpage23-
dc.description.firstpage13-
dc.relation.volume268-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000400460700002-
dc.contributor.daisngid10708998-
dc.contributor.daisngid657275-
dc.contributor.daisngid128315-
dc.contributor.daisngid384944-
dc.identifier.investigatorRIDK-5175-2014-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.ulpgces
dc.description.sjr1,033
dc.description.jcr3,296
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0002-2347-7472-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSaid Quintana, Mercedes-
crisitem.author.fullNameBrouard Martín,Ignacio-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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