Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47750
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dc.contributor.authorClavo, Bernardinoen_US
dc.contributor.authorRobaina, Franciscoen_US
dc.contributor.authorMorera Molina, Jesús Manuelen_US
dc.contributor.authorRuiz-Egea, Eugenioen_US
dc.contributor.authorPérez, Juan L.en_US
dc.contributor.authorMacías Verde, David Armandoen_US
dc.contributor.authorCaramés, Miguel Áen_US
dc.contributor.authorCatalá, Luisen_US
dc.contributor.authorHernández, Antoniaen_US
dc.contributor.authorGünderoth, Martinaen_US
dc.date.accessioned2018-11-23T16:05:55Z-
dc.date.available2018-11-23T16:05:55Z-
dc.date.issued2002en_US
dc.identifier.issn0022-3085en_US
dc.identifier.urihttp://hdl.handle.net/10553/47750-
dc.description.abstractMalignant brain tumors have been shown to decrease O2 and blood flow resulting in hypoxia and low perfusion that in turn reduce radiation sensitivity and access by chemotherapeutic agents. Spinal cord stimulation (SCS) is a procedure that has been used quite successfully in the treatment of pain and ischemic syndromes. In the present study the authors applied the method and, with polarographic probes inserted in the tumor sites, measured the changes in tissue oxygenation and hypoxia in two separate tumor areas in three patients with high-grade astrocytomas. The results of the SCS indicated that overall tumor oxygenation increased by 90% (from 13.2+/-9.4 mm Hg to 25.1+/-9.6 mm Hg; p = 0.013); the percentage of moderately hypoxic values (< 10 mm Hg) decreased by 55% (from 48.6+/-20.1% to 22+/-13.3%; p = 0.026); and the percentage of considerably hypoxic values (< 5 mm Hg) decreased by 45% (from 28+/-20.3% to 15.5+/-15%; p = 0.018). In this report the authors describe a potential novel application of SCS, and the preliminary results suggest that tumor tissue oxygenation and hypoxia are significantly improved as a result. If these findings are confirmed, the method may be applicable as an adjuvant to radiotherapy and chemotherapy regimens.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Neurosurgeryen_US
dc.sourceJournal of Neurosurgery[ISSN 0022-3085],v. 96, p. 94-100 (Enero 2002)en_US
dc.subject32 Ciencias médicasen_US
dc.subject321308 Neurocirugíaen_US
dc.subject.otherSpinal cord stimulationen_US
dc.subject.otherBrain tumoren_US
dc.subject.otherAstrocytomasen_US
dc.titleIncrease of brain tumor oxygenation during cervical spinal cord stimulation. Report of three casesen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3171/spi.2002.96.1.0094en_US
dc.identifier.scopus0036124319-
dc.contributor.authorscopusid57190093030-
dc.contributor.authorscopusid6603449723-
dc.contributor.authorscopusid35466252100-
dc.contributor.authorscopusid7801405318-
dc.contributor.authorscopusid7403417565-
dc.contributor.authorscopusid35582506700-
dc.contributor.authorscopusid6505906726-
dc.contributor.authorscopusid6701325136-
dc.contributor.authorscopusid56881666100-
dc.contributor.authorscopusid6603659763-
dc.description.lastpage100en_US
dc.description.firstpage94en_US
dc.relation.volume96en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages7en_US
dc.utils.revisionen_US
dc.date.coverdateEnero 2002en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr2,626-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0003-2522-1064-
crisitem.author.fullNameClavo Varas, Bernardino-
crisitem.author.fullNameMorera Molina, Jesús Manuel-
crisitem.author.fullNameMacías Verde, David Armando-
crisitem.author.fullNameCaramés Álvarez, Miguel Angel-
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