Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47741
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dc.contributor.authorClavo, Bernardinoen_US
dc.contributor.authorRobaina, Franciscoen_US
dc.contributor.authorMontz, Ricardoen_US
dc.contributor.authorDomper, Martaen_US
dc.contributor.authorCaramés, Miguel Áen_US
dc.contributor.authorMorera, Jesúsen_US
dc.contributor.authorPinar Sedeño, María Beatrizen_US
dc.contributor.authorHernández, María A.en_US
dc.contributor.authorSantullano, Victoriaen_US
dc.contributor.authorCarreras, José Luisen_US
dc.date.accessioned2018-11-23T16:01:36Z-
dc.date.available2018-11-23T16:01:36Z-
dc.date.issued2006en_US
dc.identifier.issn0022-3085en_US
dc.identifier.urihttp://hdl.handle.net/10553/47741-
dc.description.abstractObject In previous studies the authors have shown potential increases in locoregional blood flow and oxygenation in tumors by using electrical cervical spinal cord stimulation (SCS). In the present report they demonstrate the effect of cervical SCS on brain tumor metabolism, as assessed using [F]fluorodeoxyglucose–positron emission tomography (FDG-PET). Methods Cervical devices were inserted in 11 patients who had high-grade gliomas, six of which had recurred. While the SCS device was deactivated, each patient underwent an initial FDG-PET study to clarify the clinical status. A second FDG-PET study was performed later the same day while the stimulation device was activated to determine the effect of cervical SCS on glucose metabolism. All 11 patients were evaluable for this PET study. Basal glucose metabolism was higher in the tumor than in the peritumoral areas (p = 0.048). There was a significant increase in glucose uptake during cervical SCS in both the tumor (p = 0.035) and the peritumoral (p = 0.001) areas, with measured increases of 43 and 38%, respectively. The estimated potential maximal residual activity of the first FDG dose’s contribution to the activity on the second scan was 18.5 ± 1% or less. Conclusions This PET study is the first in which is described the effect of cervical SCS on glucose metabolism in brain tumors and supports previous study data indicating a modification of locoregional blood flow and oxygenation by cervical SCS. These results open up new approaches to modifying the effect of radiochemotherapy in the treatment of malignant brain tumors.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Neurosurgeryen_US
dc.sourceJournal of Neurosurgery[ISSN 0022-3085],v. 104, p. 537-541 (Abril 2006)en_US
dc.subject32 Ciencias médicasen_US
dc.subject321308 Neurocirugíaen_US
dc.subject.otherFluorodeoxyglucose–positron emission tomographyen_US
dc.subject.otherHigh-grade gliomaen_US
dc.subject.otherMagnetic resonanceen_US
dc.subject.otherSpinal cord stimulationen_US
dc.subject.otherSingle-photon emission computerized tomographyen_US
dc.titleModification of glucose metabolism in brain tumors by using cervical spinal cord stimulationen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3171/jns.2006.104.4.537en_US
dc.identifier.scopus33645542889-
dc.contributor.authorscopusid57190093030-
dc.contributor.authorscopusid6603449723-
dc.contributor.authorscopusid7006823048-
dc.contributor.authorscopusid6601999977-
dc.contributor.authorscopusid6505906726-
dc.contributor.authorscopusid35466252100-
dc.contributor.authorscopusid6507421079-
dc.contributor.authorscopusid8616779200-
dc.contributor.authorscopusid6507138325-
dc.contributor.authorscopusid7003828402-
dc.description.lastpage541en_US
dc.description.firstpage537en_US
dc.relation.volume104en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages5en_US
dc.utils.revisionen_US
dc.date.coverdateAbril 2006en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr2,242-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR SIANI: Ingeniería biomédica aplicada a estimulación neural y sensorial-
crisitem.author.deptIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0003-2522-1064-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameClavo Varas,Bernardino-
crisitem.author.fullNameCaramés Álvarez,Miguel Angel-
crisitem.author.fullNamePinar Sedeño, María Beatriz-
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