Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47716
Title: Ozone therapy in the management of persistent radiation-induced rectal bleeding in prostate cancer patients
Authors: Clavo, Bernardino 
Santana Rodríguez, Norberto 
Llontop, Pedro
Gutierrez, Dominga
Ceballos Santos, Daniel Sebastián 
Méndez, Charlin
Rovira, Gloria
Suarez, Gerardo
Rey-Baltar, Dolores
Garcia-Cabrera, Laura
Martínez-Sánchez, Gregorio
Fiuza, Dolores
UNESCO Clasification: 32 Ciencias médicas
320101 Oncología
Keywords: Ozone therapy
Prostate cancer
Issue Date: 2015
Journal: Evidence-Based Complementary and Alternative Medicine 
Abstract: Introduction. Persistent radiation-induced proctitis and rectal bleeding are debilitating complications with limited therapeutic options. We present our experience with ozone therapy in the management of such refractory rectal bleeding. Methods. Patients () previously irradiated for prostate cancer with persistent or severe rectal bleeding without response to conventional treatment were enrolled to receive ozone therapy via rectal insufflations and/or topical application of ozonized-oil. Ten (83%) patients had Grade 3 or Grade 4 toxicity. Median follow-up after ozone therapy was 104 months (range: 52–119). Results. Following ozone therapy, the median grade of toxicity improved from 3 to 1 () and the number of endoscopy treatments from 37 to 4 (). Hemoglobin levels changed from 11.1 (7–14) g/dL to 13 (10–15) g/dL, before and after ozone therapy, respectively (). Ozone therapy was well tolerated and no adverse effects were noted, except soft and temporary flatulence for some hours after each session. Conclusions. Ozone therapy was effective in radiation-induced rectal bleeding in prostate cancer patients without serious adverse events. It proved useful in the management of rectal bleeding and merits further evaluation.
URI: http://hdl.handle.net/10553/47716
ISSN: 1741-427X
DOI: 10.1155/2015/480369
Source: Evidence-based Complementary and Alternative Medicine[ISSN 1741-427X],v. 2015 (480369)
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