Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47650
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dc.contributor.authorRequena, T.en_US
dc.contributor.authorEspinosa-Sanchez, J. M.en_US
dc.contributor.authorCabrera, S.en_US
dc.contributor.authorTrinidad, G.en_US
dc.contributor.authorSoto-Varela, A.en_US
dc.contributor.authorSantos-Perez, S.en_US
dc.contributor.authorTeggi, R.en_US
dc.contributor.authorPerez, P.en_US
dc.contributor.authorBatuecas-Caletrio, A.en_US
dc.contributor.authorFraile, J.en_US
dc.contributor.authorAran, I.en_US
dc.contributor.authorMartin, E.en_US
dc.contributor.authorBenitez, J.en_US
dc.contributor.authorPérez-Fernández, N.en_US
dc.contributor.authorLopez-Escamez, J. A.en_US
dc.date.accessioned2018-11-23T15:16:15Z-
dc.date.available2018-11-23T15:16:15Z-
dc.date.issued2014en_US
dc.identifier.issn0009-9163en_US
dc.identifier.urihttp://hdl.handle.net/10553/47650-
dc.description.abstractThe aims of this study were to estimate the prevalence of familial cases in patients with Meniere's disease (MD) and to identify clinical differences between sporadic and familial MD. We recruited 1375 patients with definite MD according to the American Academy of Otolaryngology-Head and Neck Surgery criteria, obtaining the familial history of hearing loss or episodic vertigo by direct interview or a postal survey in 1245 cases in a multicenter study. Familial clustering was estimated by the recurrence risk ratio in siblings (λs ) and offspring (λo ) using intermediate and high prevalence values for MD in European population. A total of 431 patients (34%) reported a familial history of hearing loss or recurrent vertigo and 133 patients had a relative with possible MD. After clinical reevaluation, 93 relatives in 76 families were diagnosed of definite MD (8.4%), including three pairs of monozygotic twins. λs and λo were 16-48 and 4-12, respectively. We observed genetic heterogeneity, but most families had an autosomal dominant inheritance with anticipation. No clinical differences were found between sporadic and familial MD, except for an early onset in familial cases. We may conclude that MD has a strong familial aggregation and that sporadic and familial MDs are clinically identical.en_US
dc.languageengen_US
dc.relation.ispartofClinical geneticsen_US
dc.sourceClinical Genetics[ISSN 0009-9163],v. 85, p. 245-252en_US
dc.subject32 Ciencias médicasen_US
dc.subject320102 Genética clínicaen_US
dc.subject.otherAnticipationen_US
dc.subject.otherAutosomal dominanten_US
dc.subject.otherEndolymphatic hydropsen_US
dc.subject.otherFamilial Meniere's diseaseen_US
dc.subject.otherSensorineural hearing lossen_US
dc.subject.otherTwinsen_US
dc.subject.otherVertigoen_US
dc.titleFamilial clustering and genetic heterogeneity in Meniere's diseaseen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/cge.12150en_US
dc.identifier.scopus2-s2.0-84893006604-
dc.contributor.authorscopusid55645458300-
dc.contributor.authorscopusid6507717457-
dc.contributor.authorscopusid56425397100-
dc.contributor.authorscopusid56243371500-
dc.contributor.authorscopusid6602851776-
dc.contributor.authorscopusid6602791690-
dc.contributor.authorscopusid6503983560-
dc.contributor.authorscopusid7201902655-
dc.contributor.authorscopusid8327341500-
dc.contributor.authorscopusid56995750800-
dc.contributor.authorscopusid23472050500-
dc.contributor.authorscopusid57203581246-
dc.contributor.authorscopusid56878370600-
dc.contributor.authorscopusid6602382611-
dc.contributor.authorscopusid7003654696-
dc.description.lastpage252en_US
dc.description.firstpage245en_US
dc.relation.volume85en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages8en_US
dc.utils.revisionen_US
dc.date.coverdateMarzo 2014en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,728-
dc.description.jcr3,931-
dc.description.sjrqQ2-
dc.description.jcrqQ2-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR SIANI: Ingeniería biomédica aplicada a estimulación neural y sensorial-
crisitem.author.deptIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.parentorgIU Sistemas Inteligentes y Aplicaciones Numéricas-
crisitem.author.fullNameBenítez Del Rosario, Jesús-
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