Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/47573
Campo DC Valoridioma
dc.contributor.authorMartín de las Mulas, J.en_US
dc.contributor.authorEspinosa De Los Monteros Y Zayas, Antonioen_US
dc.contributor.authorCarrasco, L.en_US
dc.contributor.authorvan Niel, M.en_US
dc.contributor.authorFernández Rodríguez, Antonio Jesúsen_US
dc.contributor.otherFernandez, Antonio-
dc.date.accessioned2018-11-23T14:37:54Z-
dc.date.available2018-11-23T14:37:54Z-
dc.date.issued1995en_US
dc.identifier.issn0300-9858en_US
dc.identifier.urihttp://hdl.handle.net/10553/47573-
dc.description.abstractTwenty-eight epithelial and 22 nonepithelial feline tumors were studied immunohistochemically. Epithelial tumors were 10 squamous cell carcinomas, two basal cell tumors, two sebaceous gland carcinomas, three apocrine gland carcinomas, three thyroid papillary carcinomas, one thyroid solid carcinoma, one renal clear cell carcinoma, one renal papillary carcinoma, one endometrial carcinoma, and four lung bronchioloalveolar carcinomas. Nonepithelial tumors were 10 fibrosarcomas, one liposarcoma, one leiomyosarcoma, one rhabdomyosarcoma, one hemangiosarcoma, two mast cell tumors, one osteosarcoma, three melanomas, and two lymphomas. Commercially available antibodies directed against high- and low-molecular-weight keratins (keratin, RCK-102, NCL-5D3), vimentin, desmin, glial fibrillary acidic protein (GFAP), and neurofilament intermediate filament (IF) proteins were used in the avidin-biotin-peroxidase complex technique on formalin-fixed, paraffin-embedded tumor tissue samples. All epithelial tumors except the endometrial carcinoma expressed some type of keratin protein. Squamous cell carcinomas expressed high-molecular-weight keratins exclusively. Coexpression of high- and low-molecular-weight keratins was observed in one basal cell tumor, sebaceous and apocrine adenocarcinomas, and thyroid, renal, and lung carcinomas. In addition to keratins, vimentin immunoreactivity was found in all basal cell tumors, all sebaceous gland, thyroid papillary, renal, and lung adenocarcinomas, and one of the apocrine gland adenocarcinomas. Immunoreactivity with GFAP antibody was found in one basal cell tumor and one sebaceous gland adenocarcinoma. The endometrial carcinoma did not react with any of the antibodies applied. Nonepithelial tumors analyzed expressed either vimentin (fibrosarcomas, liposarcoma, haemangiosarcoma, mast cell tumors, osteosarcomas, melanomas) or vimentin and desmin (leiomyosarcoma, rhabdomyosarcoma, one fibrosarcoma) IF proteins exclusively. Lymphomas did not react with any of the antibodies employed. These findings indicate that IF proteins antibodies can be included in diagnostic panels of antibodies for immunocharacterization of feline tumors. In addition, they can be used as a basis for the diagnoses of poorly differentiated or undifferentiated feline neoplasms.en_US
dc.languagespaen_US
dc.publisher0300-9858
dc.relation.ispartofVeterinary Pathologyen_US
dc.sourceVeterinary pathology[ISSN 0300-9858],v. 32, p. 692-701en_US
dc.subject.otherRenal-Cell Carcinomasen_US
dc.subject.otherMonoclonal-Antibodiesen_US
dc.subject.otherImmunocytochemical Diagnosisen_US
dc.subject.otherTumorsen_US
dc.subject.otherVimentinen_US
dc.subject.otherExpressionen_US
dc.subject.otherRhabdomyosarcomasen_US
dc.subject.otherDesminen_US
dc.subject.otherSkinen_US
dc.subject.otherCytokeratinen_US
dc.titleImmunohistochemical distribution pattern of intermediate filament proteins in 50 feline neoplasmsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.scopus0029401950-
dc.identifier.isiA1995TF63800011-
dcterms.isPartOfVeterinary Pathology
dcterms.sourceVeterinary Pathology[ISSN 0300-9858],v. 32 (6), p. 692-701
dc.contributor.authorscopusid7003394672-
dc.contributor.authorscopusid57203026590-
dc.contributor.authorscopusid35830051000-
dc.contributor.authorscopusid6603065575-
dc.contributor.authorscopusid56673009900-
dc.description.lastpage701en_US
dc.description.firstpage692en_US
dc.relation.volume32en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:A1995TF63800011-
dc.contributor.daisngid407245-
dc.contributor.daisngid700159-
dc.contributor.daisngid821108-
dc.contributor.daisngid4794283-
dc.contributor.daisngid5614688-
dc.contributor.daisngid3873352-
dc.contributor.daisngid176520-
dc.identifier.investigatorRIDG-3448-2015-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:DELASMULAS, JM-
dc.contributor.wosstandardWOS:DELOSMONTEROS, AE-
dc.contributor.wosstandardWOS:CARRASCO, L-
dc.contributor.wosstandardWOS:VANNIEL, M-
dc.contributor.wosstandardWOS:FERNANDEZ, A-
dc.date.coverdateNoviembre 1995en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0002-7736-3139-
crisitem.author.orcid0000-0001-5281-0521-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameEspinosa De Los Monteros Y Zayas, Antonio-
crisitem.author.fullNameFernández Rodríguez, Antonio Jesús-
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