Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47150
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dc.contributor.authorTorres Padrón, M. E.en_US
dc.contributor.authorSosa Ferrera, Z.en_US
dc.contributor.authorSantana Rodríguez, J. J.en_US
dc.contributor.otherZoraida, Sosa-Ferrera-
dc.contributor.otherTorres-Padron, Maria Esther-
dc.date.accessioned2018-11-23T11:14:22Z-
dc.date.available2018-11-23T11:14:22Z-
dc.date.issued2009en_US
dc.identifier.issn0269-3879en_US
dc.identifier.urihttp://hdl.handle.net/10553/47150-
dc.description.abstractA residue analytical method combining solid-phase microextraction (SPME) with external micellar desorption (MD) and high-performance liquid chromatography with diode array detector (HPLC-DAD) has been developed and validated for the simultaneous determination of six pharmaceutical compounds, belonging to various therapeutic categories in water samples. Target compounds include antiinflamatory drugs (ibuprofen, ketoprofen and naproxen), an analgesic (phenazone), a lipid regulator (bezafibrate) and an antiepileptic (carbamazepine). A detailed study of the experimental conditions of extraction and desorption with different surfactants was performed in order to obtain the best results during instrumental analysis. Of the different fibers and surfactants investigated, 65 μm polydimethysiloxane-divinilbenzene (PDMS-DVB) fiber and polyoxyethylene 10 lauryl ether (POLE) and polyoxyethylene 6 lauryl ether (C12E6) as desorbing agents produced the optimal response to pharmaceutical residues. Recoveries obtained were generally higher than 80% and the variability of the method was below 16% for all compounds in both surfactants. Method detection limits were 0.05–12 ng mL−1 for POLE and 0.1–5 ng mL−1 for C12E6. The developed method was compared using external desorption with organic solvent and it was successfully applied to the determination of these pharmaceutical compounds in water samples from different origin. Solid-phase microextraction with micellar desorption (SPME-MD) represents a new approach for the extraction of different pharmaceutical compounds in natural waters because it combines shorter handling time, better efficiency, safety and more environmentally friendly process than the traditional methods.en_US
dc.languageengen_US
dc.publisher0269-3879-
dc.relationAcoplamiento de la Microextracción en Fase Sólida y la Cromatografía Líquida de Alta Resolución Con la Utilización de Medios Micelares Como Extractantes: Desarrollo de Nuevos Métodos Analíticosen_US
dc.relation.ispartofBiomedical Chromatographyen_US
dc.sourceBiomedical Chromatography [ISSN 0269-3879], v. 23, p. 1175-1185en_US
dc.subject2301 química analíticaen_US
dc.subject2391 Química ambientalen_US
dc.subject.otherSolid-phase microextractionen_US
dc.subject.otherMicellesen_US
dc.subject.otherPharmaceutical productsen_US
dc.subject.otherHigh-performance liquid chromatographyen_US
dc.subject.otherWater analysisen_US
dc.titleCoupling of solid-phase microextraction with micellar desorption and high performance liquid chromatography for the determination of pharmaceutical residues in environmental liquid samplesen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/bmc.1240en_US
dc.identifier.scopus70450284459-
dc.identifier.isi000271348300007-
dcterms.isPartOfBiomedical Chromatography-
dcterms.sourceBiomedical Chromatography[ISSN 0269-3879],v. 23 (11), p. 1175-1185-
dc.contributor.authorscopusid8452532700-
dc.contributor.authorscopusid6602897915-
dc.contributor.authorscopusid56248783900-
dc.description.lastpage1185en_US
dc.description.firstpage1175en_US
dc.relation.volume23en_US
dc.investigacionCienciasen_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000271348300007-
dc.contributor.daisngid22437017-
dc.contributor.daisngid3888969-
dc.contributor.daisngid1022381-
dc.contributor.daisngid770178-
dc.contributor.daisngid8799820-
dc.contributor.daisngid13402121-
dc.identifier.investigatorRIDN-1602-2014-
dc.identifier.investigatorRIDE-9038-2012-
dc.identifier.externalWOS:000271348300007-
dc.contributor.wosstandardWOS:Padron, MET-
dc.contributor.wosstandardWOS:Ferrera, ZS-
dc.contributor.wosstandardWOS:Rodriguez, JJS-
dc.date.coverdateNoviembre 2009en_US
dc.identifier.ulpgces
dc.description.jcr1,639
dc.description.jcrqQ3
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.project.principalinvestigatorSosa Ferrera, María Zoraida-
crisitem.author.deptGIR IUNAT: Análisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.deptDepartamento de Química-
crisitem.author.deptGIR IUNAT: Análisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.deptDepartamento de Química-
crisitem.author.deptGIR IUNAT: Análisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.deptDepartamento de Química-
crisitem.author.orcid0000-0001-7000-4419-
crisitem.author.orcid0000-0003-3003-3607-
crisitem.author.orcid0000-0002-5635-7215-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.fullNameTorres Padrón, María Esther-
crisitem.author.fullNameSosa Ferrera, María Zoraida-
crisitem.author.fullNameSantana Rodríguez, José Juan-
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