Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/47060
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Triana Mendez,Jorge | en_US |
dc.contributor.author | Lopez Sanchez,Mariana | en_US |
dc.contributor.author | Rico, Milagros | en_US |
dc.contributor.author | González-Platas, Javier | en_US |
dc.contributor.author | Quintana, J | en_US |
dc.contributor.author | Estevez, F | en_US |
dc.contributor.author | León, Francisco | en_US |
dc.contributor.author | Bermejo, Jaime | en_US |
dc.contributor.other | Quintana, Jose | - |
dc.contributor.other | Gonzalez-Platas, Javier | - |
dc.contributor.other | Estevez, Francisco | - |
dc.contributor.other | Rico, Milagros | - |
dc.contributor.other | Leon, Francisco | - |
dc.date.accessioned | 2018-11-23T10:31:10Z | - |
dc.date.available | 2018-11-23T10:31:10Z | - |
dc.date.issued | 2003 | en_US |
dc.identifier.issn | 0163-3864 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/47060 | - |
dc.description.abstract | Four new compounds, a sesquiterpene, eleganodiol (1), and three sesquiterpene lactones, eleganolactone A (2), eleganolactone B (3), and elegain (4), were isolated from Gonospermum elegans along with 16 known compounds. The structures of 1, 2, and 4 were determined on the basis of MS and NMR studies of their acetate derivatives (1a, 2a, 4a). The structure of the acetate derivative (3a) of 3 was determined on the basis of spectroscopic data interpretation and by single-crystal X-ray diffraction. Compounds 2a and 3a were used to study their biological activities on the HL-60 human promyelocytic leukemia cell line. These compounds induced morphological changes and internucleosomal DNA fragmentation characteristic of apoptotic cell death. | en_US |
dc.language | eng | en_US |
dc.publisher | 0163-3864 | - |
dc.relation.ispartof | Journal of Natural Products | en_US |
dc.source | Journal Of Natural Products [ISSN 0163-3864], v. 66 (7), p. 943-948 | en_US |
dc.subject | 230690 Química de productos naturales orgánicos | en_US |
dc.subject.other | Lactones | |
dc.subject.other | Constituents | |
dc.subject.other | Apoptosis | |
dc.subject.other | Growth | |
dc.subject.other | Assay | |
dc.title | Sesquiterpenoid derivatives from Gonospermum elegans and their cytotoxic activity for HL-60 human promyelocytic cells | en_US |
dc.type | info:eu-repo/semantics/Article | es |
dc.type | Article | es |
dc.identifier.doi | 10.1021/np020390y | |
dc.identifier.scopus | 0042343833 | - |
dc.identifier.isi | 000184412800008 | - |
dcterms.isPartOf | Journal Of Natural Products | - |
dcterms.source | Journal Of Natural Products[ISSN 0163-3864],v. 66 (7), p. 943-948 | - |
dc.contributor.authorscopusid | 6602859915 | - |
dc.contributor.authorscopusid | 22985994700 | - |
dc.contributor.authorscopusid | 56228014200 | - |
dc.contributor.authorscopusid | 6602697986 | - |
dc.contributor.authorscopusid | 8681043500 | - |
dc.contributor.authorscopusid | 7003810011 | - |
dc.contributor.authorscopusid | 7005039451 | - |
dc.contributor.authorscopusid | 7101636723 | - |
dc.description.lastpage | 948 | - |
dc.description.firstpage | 943 | - |
dc.relation.volume | 66 | - |
dc.investigacion | Ciencias | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.wos | WOS:000184412800008 | - |
dc.contributor.daisngid | 1400733 | - |
dc.contributor.daisngid | 5158464 | - |
dc.contributor.daisngid | 2857141 | - |
dc.contributor.daisngid | 424768 | - |
dc.contributor.daisngid | 128315 | - |
dc.contributor.daisngid | 384944 | - |
dc.contributor.daisngid | 136703 | - |
dc.contributor.daisngid | 5695465 | - |
dc.identifier.investigatorRID | K-5709-2014 | - |
dc.identifier.investigatorRID | I-1937-2015 | - |
dc.identifier.investigatorRID | K-5125-2014 | - |
dc.identifier.investigatorRID | No ID | - |
dc.identifier.investigatorRID | No ID | - |
dc.identifier.external | WOS:000184412800008 | - |
dc.contributor.wosstandard | WOS:Triana, J | |
dc.contributor.wosstandard | WOS:Lopez, M | |
dc.contributor.wosstandard | WOS:Rico, M | |
dc.contributor.wosstandard | WOS:Gonzalez-Platas, J | |
dc.contributor.wosstandard | WOS:Quintana, J | |
dc.contributor.wosstandard | WOS:Estevez, F | |
dc.contributor.wosstandard | WOS:Leon, F | |
dc.contributor.wosstandard | WOS:Bermejo, J | |
dc.date.coverdate | Julio 2003 | |
dc.identifier.ulpgc | Sí | es |
dc.description.jcr | 1,849 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
item.fulltext | Sin texto completo | - |
item.grantfulltext | none | - |
crisitem.author.dept | GIR IOCAG: Química Marina | - |
crisitem.author.dept | IU de Oceanografía y Cambio Global | - |
crisitem.author.dept | Departamento de Química | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.orcid | 0000-0002-2711-8952 | - |
crisitem.author.orcid | 0000-0001-8225-4538 | - |
crisitem.author.orcid | 0000-0002-9728-2774 | - |
crisitem.author.parentorg | IU de Oceanografía y Cambio Global | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Triana Mendez,Jorge | - |
crisitem.author.fullName | Lopez Sanchez,Mariana | - |
crisitem.author.fullName | Rico Santos, Milagros | - |
crisitem.author.fullName | Quintana Aguiar, José Martín | - |
crisitem.author.fullName | Estévez Rosas, Francisco Jesús | - |
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