Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47060
DC FieldValueLanguage
dc.contributor.authorTriana Mendez,Jorgeen_US
dc.contributor.authorLopez Sanchez,Marianaen_US
dc.contributor.authorRico, Milagrosen_US
dc.contributor.authorGonzález-Platas, Javieren_US
dc.contributor.authorQuintana, Jen_US
dc.contributor.authorEstevez, Fen_US
dc.contributor.authorLeón, Franciscoen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.otherQuintana, Jose-
dc.contributor.otherGonzalez-Platas, Javier-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherRico, Milagros-
dc.contributor.otherLeon, Francisco-
dc.date.accessioned2018-11-23T10:31:10Z-
dc.date.available2018-11-23T10:31:10Z-
dc.date.issued2003en_US
dc.identifier.issn0163-3864en_US
dc.identifier.urihttp://hdl.handle.net/10553/47060-
dc.description.abstractFour new compounds, a sesquiterpene, eleganodiol (1), and three sesquiterpene lactones, eleganolactone A (2), eleganolactone B (3), and elegain (4), were isolated from Gonospermum elegans along with 16 known compounds. The structures of 1, 2, and 4 were determined on the basis of MS and NMR studies of their acetate derivatives (1a, 2a, 4a). The structure of the acetate derivative (3a) of 3 was determined on the basis of spectroscopic data interpretation and by single-crystal X-ray diffraction. Compounds 2a and 3a were used to study their biological activities on the HL-60 human promyelocytic leukemia cell line. These compounds induced morphological changes and internucleosomal DNA fragmentation characteristic of apoptotic cell death.en_US
dc.languageengen_US
dc.publisher0163-3864-
dc.relation.ispartofJournal of Natural Productsen_US
dc.sourceJournal Of Natural Products [ISSN 0163-3864], v. 66 (7), p. 943-948en_US
dc.subject230690 Química de productos naturales orgánicosen_US
dc.subject.otherLactones
dc.subject.otherConstituents
dc.subject.otherApoptosis
dc.subject.otherGrowth
dc.subject.otherAssay
dc.titleSesquiterpenoid derivatives from Gonospermum elegans and their cytotoxic activity for HL-60 human promyelocytic cellsen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1021/np020390y
dc.identifier.scopus0042343833-
dc.identifier.isi000184412800008-
dcterms.isPartOfJournal Of Natural Products-
dcterms.sourceJournal Of Natural Products[ISSN 0163-3864],v. 66 (7), p. 943-948-
dc.contributor.authorscopusid6602859915-
dc.contributor.authorscopusid22985994700-
dc.contributor.authorscopusid56228014200-
dc.contributor.authorscopusid6602697986-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid7101636723-
dc.description.lastpage948-
dc.description.firstpage943-
dc.relation.volume66-
dc.investigacionCienciasen_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000184412800008-
dc.contributor.daisngid1400733-
dc.contributor.daisngid5158464-
dc.contributor.daisngid2857141-
dc.contributor.daisngid424768-
dc.contributor.daisngid128315-
dc.contributor.daisngid384944-
dc.contributor.daisngid136703-
dc.contributor.daisngid5695465-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDI-1937-2015-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.identifier.externalWOS:000184412800008-
dc.contributor.wosstandardWOS:Triana, J
dc.contributor.wosstandardWOS:Lopez, M
dc.contributor.wosstandardWOS:Rico, M
dc.contributor.wosstandardWOS:Gonzalez-Platas, J
dc.contributor.wosstandardWOS:Quintana, J
dc.contributor.wosstandardWOS:Estevez, F
dc.contributor.wosstandardWOS:Leon, F
dc.contributor.wosstandardWOS:Bermejo, J
dc.date.coverdateJulio 2003
dc.identifier.ulpgces
dc.description.jcr1,849
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IOCAG: Química Marina-
crisitem.author.deptIU de Oceanografía y Cambio Global-
crisitem.author.deptDepartamento de Química-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0002-2711-8952-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Oceanografía y Cambio Global-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameTriana Mendez,Jorge-
crisitem.author.fullNameLopez Sanchez,Mariana-
crisitem.author.fullNameRico Santos, Milagros-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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