Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/47002
Campo DC Valoridioma
dc.contributor.authorNavarro, D.en_US
dc.contributor.authorCabrera, J. J.en_US
dc.contributor.authorLeón Arencibia, Laureanoen_US
dc.contributor.authorChirino, R.en_US
dc.contributor.authorFernández, L.en_US
dc.contributor.authorLópez, A.en_US
dc.contributor.authorRivero, J. F.en_US
dc.contributor.authorFernández, P.en_US
dc.contributor.authorFalcón, O.en_US
dc.contributor.authorJiménez, P.en_US
dc.contributor.authorPestano, J.en_US
dc.contributor.authorDíaz-Chico, J. C.en_US
dc.contributor.authorDíaz-Chico, B. N.en_US
dc.contributor.otherPestano Brito, Jose Juan-
dc.contributor.otherCabrera-Galvan, Juan Jose-
dc.date.accessioned2018-11-23T10:04:08Z-
dc.date.available2018-11-23T10:04:08Z-
dc.date.issued1992en_US
dc.identifier.issn0960-0760en_US
dc.identifier.urihttp://hdl.handle.net/10553/47002-
dc.description.abstractThe endometrial stroma plays a decisive role in sustaining the gland epithelium along the menstrual cycle, and in preparing the microenvironment that allows embryo implantation. The stroma undergoes important changes during the menstrual cycle that affects both the cell number and differentiation. These changes are regulated by both estrogen and progesterone.Stromal sarcomas are extremely rare, occurring much less than any other uterine tumor. Their origin and biology are poorly understood. The purpose of this work was to try to learn more about the stromal physiology, and also to ascertain whether the stromal sarcoma has characteristics of hormone dependence. We studied the presence of estrogen receptors (ER), progesterone receptors (PR) and the stress-responsive protein of 27K (srp27, a protein first described as an estrogen-induced 24K protein in MCF-7 cells) in both normal stroma and stromal sarcoma. The ER and PR were measured by exchange assays. The srp 27 was studied both by Western-blot and by IHC by means of specific monoclonal antibodies.The stromal sarcomas studied showed a high concentration of both ER (96 to 116 fmol/mg prot.) and PR (565 to 995 fmol/mg prot.). These amounts of ER and PR were higher than the mean found in normal endometrium during the proliferative phase (43 and 637 fmol/mg prot., respectively), and much higher than that of the secretory phase (17 and 229 fmol/mg prot., respectively). The srp27 characterized by Western-blot in both the normal stroma and stromal sarcoma was found to be similar to the srp27 of breast cancer. The IHC results showed a very low expression of srp27 in the stroma during the proliferative phase that increases when the endometrium enters the secretory phase. The low-malignancy grade stromal sarcomas showed abundant expression of srp27, but the high-malignancy grade sarcomas showed no expression of srp27.The obtained results prove the stroma capability to express the srp27. A negative correlation between malignancy of stromal tumors and srp27 expression was found. The presence of ER and PR in some stromal sarcomas proves that they have characteristics of hormone responsiveness. These findings suggest that ER and PR assays should be routinely performed in stromal sarcomas as well as in endometrial adenocarcinomas, and also that antiesterogenic drugs might be considered for the treatment of ER and PR positive stromal sarcomas.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Steroid Biochemistry and Molecular Biologyen_US
dc.sourceJournal of Steroid Biochemistry and Molecular Biology [ISSN 0960-0760], v. 41 (3-8), p. 589-596en_US
dc.subject32 Ciencias médicasen_US
dc.subject2403 Bioquímicaen_US
dc.subject2415 Biología molecularen_US
dc.subject.otherMonoclonal-Antibodyen_US
dc.subject.otherRegulated Proteinen_US
dc.subject.otherMenstrual-Cycleen_US
dc.subject.otherHuman-Tissuesen_US
dc.subject.otherBindingen_US
dc.subject.otherUterusen_US
dc.subject.otherCanceren_US
dc.subject.otherCervixen_US
dc.subject.otherCellsen_US
dc.titleEndometrial stromal sarcoma expression of estrogen receptors, progesterone receptors and estrogen-induced srp27 (24K) suggests hormone responsivenessen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/0960-0760(92)90389-Zen_US
dc.identifier.scopus0026562428-
dc.identifier.isiA1992HN84700046-
dcterms.isPartOfJournal Of Steroid Biochemistry And Molecular Biology-
dcterms.sourceJournal Of Steroid Biochemistry And Molecular Biology[ISSN 0960-0760],v. 41 (3-8), p. 589-596-
dc.contributor.authorscopusid7004873659-
dc.contributor.authorscopusid6602257053-
dc.contributor.authorscopusid19234933700-
dc.contributor.authorscopusid6701324062-
dc.contributor.authorscopusid7202848203-
dc.contributor.authorscopusid57206586568-
dc.contributor.authorscopusid57206586568-
dc.contributor.authorscopusid7006478821-
dc.contributor.authorscopusid6603469417-
dc.contributor.authorscopusid6603752888-
dc.contributor.authorscopusid57197533993-
dc.contributor.authorscopusid56149756400-
dc.contributor.authorscopusid6701492347-
dc.contributor.authorscopusid7003603506-
dc.description.lastpage596en_US
dc.identifier.issue3-8-
dc.description.firstpage589en_US
dc.relation.volume41en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:A1992HN84700046-
dc.contributor.daisngid359684-
dc.contributor.daisngid4106512-
dc.contributor.daisngid1841045-
dc.contributor.daisngid2630973-
dc.contributor.daisngid411603-
dc.contributor.daisngid880609-
dc.contributor.daisngid795544-
dc.contributor.daisngid6838795-
dc.contributor.daisngid24608052-
dc.contributor.daisngid11441624-
dc.contributor.daisngid3779329-
dc.contributor.daisngid17889659-
dc.contributor.daisngid1217537-
dc.contributor.daisngid30543541-
dc.contributor.daisngid23582-
dc.contributor.daisngid30406180-
dc.contributor.daisngid865329-
dc.contributor.daisngid749099-
dc.contributor.daisngid1724161-
dc.identifier.investigatorRIDA-9640-2017-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages8en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:NAVARRO, D-
dc.contributor.wosstandardWOS:CABRERA, JJ-
dc.contributor.wosstandardWOS:LEON, L-
dc.contributor.wosstandardWOS:CHIRINO, R-
dc.contributor.wosstandardWOS:FERNANDEZ, L-
dc.contributor.wosstandardWOS:LOPEZ, A-
dc.contributor.wosstandardWOS:RIVERO, JF-
dc.contributor.wosstandardWOS:FERNANDEZ, P-
dc.contributor.wosstandardWOS:FALCON, O-
dc.contributor.wosstandardWOS:JIMENEZ, P-
dc.contributor.wosstandardWOS:PESTANO, J-
dc.contributor.wosstandardWOS:DIAZCHICO, JC-
dc.contributor.wosstandardWOS:DIAZCHICO, BN-
dc.date.coverdateEnero 1992en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUIBS: Diabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0002-4184-6403-
crisitem.author.orcid0000-0002-5681-8931-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.orcid0000-0001-5865-7003-
crisitem.author.orcid0000-0001-6454-4785-
crisitem.author.orcid0000-0002-0944-990X-
crisitem.author.orcid0000-0002-0944-990X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameCabrera Galván,Juan José-
crisitem.author.fullNameLeón Arencibia, Laureano-
crisitem.author.fullNameChirino Godoy, Ricardo-
crisitem.author.fullNameFernández Pérez, Leandro Francisco-
crisitem.author.fullNameFernández Valerón, Josefa Pilar-
crisitem.author.fullNamePestano Brito, José Juan-
crisitem.author.fullNameDíaz Chico, Juan Carlos-
crisitem.author.fullNameDíaz Chico, Juan Carlos-
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